FBgn0063485 @ dm6

Biotype

protein_coding

Gene Symbol

Lasp

Description

The gene Lasp is referred to in FlyBase by the symbol DmelLasp (CG3849, FBgn0063485). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 3L:16676406..16711677. Its molecular function is described by: protein binding; actin filament binding; actin binding. It is involved in the biological process described with 7 unique terms, many of which group under: regulation of multicellular organismal process; cellular component assembly involved in morphogenesis; regulation of system process; regulation of myofibril size; positive regulation of oocyte development. 41 alleles are reported. The phenotypes of these alleles manifest in: germline cyst; adult integumentary system; external sensory organ; spermatid cyst; adult. The phenotypic classes of alleles include: phenotype; lethal - all die before end of P-stage; increased mortality during development; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages.

Coordinates

chr3L:16676406-16711677:-

Assembly

dm6

GENOMIC BROWSER[edit]

EXPRESSION VALUES[edit]

SPECIAL DATASETS

Neural diversity
Neurogenesis
Neuronal activity
Splicing factor regulation (brain)
Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event

Type

Length

Coordinates

Strand

PSI Average

PSI Range

Annotated Functions

DmeEX0004916

Exon Skipping

666

chr3L:16678808-16679473

-

90.94

71.64

0

Orthologous genes[edit]

Organism	Assembly	Gene ID	Gene Name	Orthology Type
Human	hg38	ENSG00000002834	LASP1	1-to-4
Human	hg38	ENSG00000078114	NEBL	1-to-4
Human	hg38	ENSG00000183091	NEB	1-to-4
Human	hg38	ENSG00000197893	NRAP	1-to-4
Human	hg19	ENSG00000002834	LASP1	1-to-4
Human	hg19	ENSG00000078114	NEBL	1-to-4
Human	hg19	ENSG00000183091	NEB	1-to-4
Human	hg19	ENSG00000197893	NRAP	1-to-4
Mouse	mm10	ENSMUSG00000026950	Neb	1-to-4
Mouse	mm10	ENSMUSG00000038366	Lasp1	1-to-4
Mouse	mm10	ENSMUSG00000049134	Nrap	1-to-4
Mouse	mm10	ENSMUSG00000053702	Nebl	1-to-4
Mouse	mm9	ENSMUSG00000026950	Neb	1-to-4
Mouse	mm9	ENSMUSG00000038366	Lasp1	1-to-4
Mouse	mm9	ENSMUSG00000049134	Nrap	1-to-4
Mouse	mm9	ENSMUSG00000053702	Nebl	1-to-4
Rat	rn6	ENSRNOG00000004132	Lasp1	1-to-4
Rat	rn6	ENSRNOG00000006783	Neb	1-to-4
Rat	rn6	ENSRNOG00000016714	Nrap	1-to-4
Rat	rn6	ENSRNOG00000049452	Nebl	1-to-4
Cow	bosTau6	ENSBTAG00000006907	NEB	1-to-4
Cow	bosTau6	ENSBTAG00000013339	NEBL	1-to-4
Cow	bosTau6	ENSBTAG00000019327	NRAP	1-to-4
Cow	bosTau6	ENSBTAG00000030587	LASP1	1-to-4
Chicken	galGal4	ENSGALG00000008914	NRAP	1-to-8
Chicken	galGal3	ENSGALG00000008914	NRAP	1-to-8
Zebrafish	danRer10	ENSDARG00000009341	nrap	1-to-4
Zebrafish	danRer10	ENSDARG00000021200	nebl	1-to-4
Zebrafish	danRer10	ENSDARG00000032630	neb	1-to-4
Zebrafish	danRer10	ENSDARG00000057867	lasp1	1-to-4