DmeEX0005275 @ dm6
Exon Skipping
Gene
FBgn0085434 | NaCP60E
Description
The gene Na channel protein 60E is referred to in FlyBase by the symbol DmelNaCP60E (CG34405, FBgn0085434). It is a protein_coding_gene from Dmel. It has 11 annotated transcripts and 11 polypeptides (9 unique). Gene sequence location is 2R:24891614..24921677. Its molecular function is described by: voltage-gated sodium channel activity; voltage-gated cation channel activity; cation channel activity. It is involved in the biological process described with: sodium ion transmembrane transport; neuronal action potential; olfactory behavior; membrane depolarization during action potential; sodium ion transport. 40 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: behavior defective; viable; smell perception defective; chemical resistant. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-12 and 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
Coordinates
chr2R:24915281-24917577:+
Coord C1 exon
chr2R:24915281-24915462
Coord A exon
chr2R:24916772-24916890
Coord C2 exon
chr2R:24917320-24917577
Length
119 bp
Sequences
Splice sites
3' ss Seq
TAAACTATTACTATTATTAGCGG
3' ss Score
0.54
5' ss Seq
AAAGTAATT
5' ss Score
3.64
Exon sequences
Seq C1 exon
GTGAGTCGTCGAGGCACTGCCTGCTCCAGTCGAGCCTCGTCTCGAAAATCGTCGCGTGCCTCGGATGCATCCGATCTTAGCGAACTAGCTGGGCCTTGGTTGAACCTGCCTCTGATGCTCGTCTCAGGTGCCGACGAAGTAGTCAAGGATATAAAACAGCAAAACGACGAGCTGGGCAAACG
Seq A exon
CGGTAGCATTTTTGTGGAAGCGCCTAGAGCAAGTCGTCGCCGAAGCTTTTATAATTTCTTTTTGCGTCATCAGGATGCTGTCGATGACAGCTTAACCTCACCTTCAGTACATAGAAAAA
Seq C2 exon
CCGCAATGAACAACACGACCAACACCACCTCAAACTCCGCCTCCACCTCCGGCACGGCCTCCTCCACCGCCACCGCCCCAGCCACTGGGTGTGGCCCAGCAGCCACCTCCGCCTCCGACAGCGACCGACACCAGGCGGTGGGGGGTGGGTCGGCTCCATCACGTAAGCGCGCCTCTAGTTTCATTCGCAAGAAACCGCCCCTAGAAAGAGGTTTGTCAGCACAAAGCGCTTTAAGAGTAAACAAGAACGCTTTTGTCT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0085434_MULTIEX1-2/3=C1-3
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.461 A=0.447 C2=0.934
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0303273
Main Skipping Isoform:
FBpp0300666
Other Inclusion Isoforms:
FBpp0300661, FBpp0300662, FBpp0300663, FBpp0300665
Other Skipping Isoforms:
FBpp0300664
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCTCTGATGCTCGTCTCAGGT
R:
TGAAACTAGAGGCGCGCTTAC
Band lengths:
257-376
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)