Special

DmeEX0007182 @ dm6

Exon Skipping

Gene
FBgn0011300 | babo
Description
The gene baboon is referred to in FlyBase by the symbol Dmel�abo (CG8224, FBgn0011300). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 2R:8952339..8962796. Its molecular function is described by 6 unique terms, many of which group under: protein kinase activity; catalytic activity; phosphotransferase activity, alcohol group as acceptor; kinase activity; catalytic activity, acting on a protein. It is involved in the biological process described with 22 unique terms, many of which group under: cellular protein metabolic process; cell projection organization; primary metabolic process; brain development; response to abiotic stimulus. 51 alleles are reported. The phenotypes of these alleles manifest in: membrane-bounded organelle; vacuole; embryonic/larval brain; larval thorax; plasma membrane bounded cell projection. The phenotypic classes of alleles include: neuroanatomy defective; phototaxis defective; increased mortality; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr2R:8954734-8955858:+
Coord C1 exon
chr2R:8954734-8954851
Coord A exon
chr2R:8954959-8955167
Coord C2 exon
chr2R:8955713-8955858
Length
209 bp
Sequences
Splice sites
3' ss Seq
CGATCTATCGAGCGATGCAGATG
3' ss Score
-0.89
5' ss Seq
AAGGTGCGT
5' ss Score
9.49
Exon sequences
Seq C1 exon
ACAAGATAAAATGCCACTGTGACACGTGCAAGGAATCGAACAATATATGTGAAACGGACGGCTTTTGTTTCACGTCCGTGGAGAAGAACTCTGATGGGAGCATCATCTTCAGCTACAG
Seq A exon
ATGTCTGCACAAGTCTCAAATCTTTCCGCCGGGCCGCTCCATCTGGTGTAACGACGGGCTGCACGGCGGACCAACCGCCCGCCCAGTGGGTCGCAATGGCGCCCACGCCTGCTGCAAGGACAGGGACTTCTGCAACCGATTTCTGTGGCCAAAGACGAAGGACCAGAGGAGTGATCGTGTCGAAGAAGGGCGGCAAATCTCCGTCCAAG
Seq C2 exon
TTGCATGGTTGTCAAGTACAATATGCAACGGAGTAAGCCCTTCGAATGCCTCACCAGTAACGAAAGGTTCGATACGTATAGGATTGATTGCTGTAAGAGTGATTTCTGCAATAAGAATGAGATTATGAAGAGGATATTTGAAACAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0011300-'2-3,'2-2,3-3
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact

In the CDS, with uncertain impact

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.056 C2=0.000
Domain overlap (PFAM):

C1:
PF0106418=Activin_recp=PU(41.1=92.5)
A:
PF0106418=Activin_recp=PD(57.8=73.2)
C2:
PF0106418=Activin_recp=PD(53.7=88.0)


Main Inclusion Isoform:
FBpp0087739


Main Skipping Isoform:
FBpp0087740


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGATAAAATGCCACTGTGACACGT
R:
TCTCATTCTTATTGCAGAAATCACTC
Band lengths:
237-446
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)