DmeEX0007401 @ dm6
Exon Skipping
Gene
FBgn0000251 | cad
Description
The gene caudal is referred to in FlyBase by the symbol Dmelcad (CG1759, FBgn0000251). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (2 unique). Gene sequence location is 2L:20770731..20783135. Its molecular function is described by: RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with 17 unique terms, many of which group under: gastrulation; embryo development; gastrulation involving germ band extension; regulation of antimicrobial peptide production; genital disc development. 34 alleles are reported. The phenotypes of these alleles manifest in: developing embryonic structure; embryonic/larval hindgut; adult thoracic segment; periphallic sclerite; sensillum. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chr2L:20770731-20783135:+
Coord C1 exon
chr2L:20770731-20771909
Coord A exon
chr2L:20776567-20776620
Coord C2 exon
chr2L:20781799-20783135
Length
54 bp
Sequences
Splice sites
3' ss Seq
TAATTCCCGTCGAATCGCAGACC
3' ss Score
5.26
5' ss Seq
GCGGTAGGA
5' ss Score
6.86
Exon sequences
Seq C1 exon
GGCCCACCAGCTGATGCAGCAGCACCACCATCATCACGCCCATGCCTCCAGCAGTTCCGCCAGTTCCGGGAGCAGCAGTAGCGGTGGTGCACCGGGTGCGCCCCAGCTCAACGAGACCAACAGCAGCATCGGCGTCGGAGGAGCAGGCGGTGGCGGTGGTGTTGGCGGGGCCACCGATGGAGGACCAGGTTCCGCACCACCCAACCATCAGCAGCACATCGCCGAAGGTCTGCCGTCGCCACCGATTACCGTTTCGGGCTCGGAAATCTCTAGCCCGGGGGCGCCGACTTCTGCCTCGTCGCCGCATCATCACTTGGCACACCATTTGAGTGCCGTCGCCAACAACAACAACAACAACAACAACAACAACAATAGCCCATCCACCCATAACAACAACAACAATAACAATTCGGTGAGCAACAACAACAGGACATCGCCATCGAAGCCGCCATACTTCGACTGGATGAAGAAGCCCGCCTATCCAGCACAACCACAACCAG
Seq A exon
ACCTGAGCAGCTCGCCCAACTTAGAGGATCTGAGTGATTTGCTGGACGCAAGCG
Seq C2 exon
GCAAAACCCGCACCAAGGATAAGTACCGCGTGGTGTACACCGACTTCCAGCGCCTGGAGCTGGAGAAGGAGTACTGCACCTCCCGCTACATCACCATCCGGCGGAAGAGCGAGCTCGCCCAGACGCTGTCGCTGTCGGAGCGCCAGGTTAAGATCTGGTTCCAGAACCGCCGCGCCAAGGAGCGCAAGCAGAACAAGAAGGGTAGCGATCCGAACGTGATGGGCGTGGGAGTGCAGCATGCGGACTACAGCCAGCTGCTGGACGCCAAAGCGAAGCTGGAGCCGGGCCTGCACCTGTCCCACTCGCTGGCCCACTCGATGAACCCCATGGCGGCGATGAACATTCCCGCCATGCGCCTGCATCCCCACCTGGCCGCCCACAGCCACTCCTTGGCGGCGGTGGCGGCGCACTCACACCAGCTGCAGCAGCAGCACAGTGCGCAGATGTCCGCTGCGGCGGCAGTGGGCACGCTCTCGATGTGACACGACCATTCCTGTTAT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000251_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.821 A=1.000 C2=0.475
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
PF0004624=Homeobox=WD(100=35.4)
Main Inclusion Isoform:
FBpp0307151

Main Skipping Isoform:
FBpp0080942

Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0089336
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCGCCATACTTCGACTGGATG
R:
GGGAGGTGCAGTACTCCTTCT
Band lengths:
139-193
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)