DmeEX0007701 @ dm6
Exon Skipping
Gene
FBgn0053196 | dp
Description
The gene dumpy is referred to in FlyBase by the symbol Dmeldpy (CG33196, FBgn0053196). It is a protein_coding_gene from Dmel. It has 17 annotated transcripts and 17 polypeptides (16 unique). Gene sequence location is 2L:4477462..4614300. Its molecular function is described by: zinc ion binding; DNA-binding transcription factor activity; extracellular matrix structural constituent; calcium ion binding. It is involved in the biological process described with 6 unique terms, many of which group under: cuticle development; RNA biosynthetic process; chitin-based cuticle attachment to epithelium; chitin-based embryonic cuticle biosynthetic process; regulation of cellular macromolecule biosynthetic process. 332 alleles are reported. The phenotypes of these alleles manifest in: epidermal cell; cephalic branch; mesothoracic tergum; adult abdomen; adult trachea. The phenotypic classes of alleles include: increased mortality during development; phenotype; modifier of variegation; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
Coordinates
chr2L:4485508-4503526:-
Coord C1 exon
chr2L:4503221-4503526
Coord A exon
chr2L:4502517-4503164
Coord C2 exon
chr2L:4485508-4487193
Length
648 bp
Sequences
Splice sites
3' ss Seq
ATATAATGCGCCACCTATAGTTG
3' ss Score
2.39
5' ss Seq
AACGTAAGC
5' ss Score
7.35
Exon sequences
Seq C1 exon
TTGATGTATACCGTAACCCTTGCAATCCCTCGCCATGCGGCTCCTATGCTGAATGTCGGGAGCAGAACGGTCAAGCGGTGTGCAGTTGTCTTCCCAACTACTTTGGGGTACCACCCTCGTGTCGACCCGAGTGTAGCACCAACTACGATTGTTCCCCAAGCTTGGCGTGTCAGAATCAGCGCTGCGTCGATCCTTGTCCTGGAGCTTGTGGCGCCTACGCCGAGTGCCGAACAGTCAACCACAGTCCTTTCTGTAGTTGCAGACCCGGCTATACGGGAAATCCCATTGTCCAATGTCATATGATTA
Seq A exon
TTGAGCCCCAGCGGGATATCACACCCAAAGATCCTTGCCAACCCTCACCCTGTGGTCCAAACAGCGAATGTCGACGCGTAGGAGAAACACCCTCCTGCTCCTGCCTGTCCAATTTCTTTGGCACTCCGCCCAACTGTCGACCTGAATGTGTCTCCAATTCCGAGTGCAGTCAGGTGCATGTCTGCTCAAATAATCGCTGCAAGGATCCGTGCCCGGGTCTCTGCGGAACTGATGCCGTCTGCCGCGTGATAAGTCACAGCGCTATGTGCTACTGCCAGCCGGGTTACAGCGGCGATCCCTTCGTCCGTTGTGCACCACACATTCAAAGGGAATCGATTGAGATAGTGCAGCCCTGCAACCCCAATCCCTGCGGCGCCTTTGCCGAGTGTCGTCAGCAGAATGGAGTCGGATCGTGTCAGTGTCTACCAGAGTATTTCGGCAATCCTTATGAAGGATGTCGTCCTGAATGTGTACTTGACTCTGATTGCCCCTCTCAGCTGGCCTGTGTCAATCAAAAATGCCGTGATCCCTGTCCCGGAAGCTGCGGCCAAAATGCCGAATGCTTTGTGCGCAATCACCTGCCCACTTGTAACTGCCTCAGTGGCTATGTGGGTGACCCATATCGGTATTGTAGCATCGAACCGAAAC
Seq C2 exon
ACGAACCAAAGCCACCACCAACTCCCAAGAATCCTTGCTACCCTTCGCCCTGCGGAACCAATGCTGTGTGCCGCGTTCAAGGAGAGAACTACGTCTGCGAGTGCAGCCAACTGGAGTACATCGGCAATCCCTACGAGGGTTGTCGCCCCGAATGTGTGGGCAACTCCGAGTGCCCGGCCAATCAGGCTTGCATTCGCAGCAAGTGCCAGGATCCTTGTCCAGGAGTTTGCGGACTGGAGGCCATTTGCACCATGAACAATCACATACCGATCTGCTCTTGCCCGCCTGGCTACACTGGCAACGCGTTTGCCCAGTGTACGCGTCAGGTAACACCACCTCCTCCCTCGGATCCTTGCTACCCGTCCCCATGTGGACCCAATTCGATATGCCGAATTCAGAACGAGAAGGCCGTGTGCGAGTGCCTGCCCGGATTCTTCGGAAATCCGCTGGCCCAGGGATGTCGCCCTGAATGCACCCTGAGTTCGGACTGCGCCAAGGAT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0053196_MULTIEX2-40/55=39-55
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.002
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
PF129472=EGF_3=WD(100=5.3),PF129472=EGF_3=WD(100=6.2)
Main Inclusion Isoform:
FBpp0304622
Main Skipping Isoform:
FBpp0304628
Other Inclusion Isoforms:
FBpp0304620, FBpp0304621, FBpp0304623, FBpp0304624, FBpp0304625, FBpp0304626, FBpp0304627, FBpp0304630, FBpp0304631, FBpp0304632
Other Skipping Isoforms:
NA
Associated events
- DmeEX0007667
- DmeEX0007674
- DmeEX0007675
- DmeEX0007676
- DmeEX0007677
- DmeEX0007678
- DmeEX0007679
- DmeEX0007680
- DmeEX0007681
- DmeEX0007682
- DmeEX0007683
- DmeEX0007684
- DmeEX0007685
- DmeEX0007686
- DmeEX0007687
- DmeEX0007688
- DmeEX0007689
- DmeEX0007690
- DmeEX0007691
- DmeEX0007692
- DmeEX0007693
- DmeEX0007694
- DmeEX0007695
- DmeEX0007696
- DmeEX0007697
- DmeEX0007698
- DmeEX0007699
- DmeEX0007700
- DmeEX0007702
- DmeEX0007703
- DmeEX0007704
- DmeEX0007705
- DmeEX0007706
- DmeEX0007707
- DmeEX0007708
- DmeEX0007709
- DmeEX0007710
- DmeEX0007712
- DmeEX0007713
- DmeEX0007714
- DmeEX0007715
- DmeEX0007716
- DmeEX0007717
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGTGTGCAGTTGTCTTCCCAA
R:
GTACTCCAGTTGGCTGCACTC
Band lengths:
349-997
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)