DmeEX0007916 @ dm6
Exon Skipping
Gene
FBgn0005558 | ey
Description
The gene eyeless is referred to in FlyBase by the symbol Dmeley (CG1464, FBgn0005558). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 4:697689..721173. Its molecular function is described by: RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding. It is involved in the biological process described with 19 unique terms, many of which group under: growth; sensory system development; post-embryonic development; sensory organ morphogenesis; cellular response to stimulus. 86 alleles are reported. The phenotypes of these alleles manifest in: medulla; cellular anatomical entity; eye disc; hemolymph; visual system. The phenotypic classes of alleles include: increased mortality during development; increased cell death; phenotype; visible. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages.
Coordinates
chr4:713858-717929:+
Coord C1 exon
chr4:713858-714512
Coord A exon
chr4:717127-717300
Coord C2 exon
chr4:717654-717929
Length
174 bp
Sequences
Splice sites
3' ss Seq
TTAAAACTGTATTTTGCCAGAAC
3' ss Score
4.59
5' ss Seq
AAGGTAAAA
5' ss Score
8.38
Exon sequences
Seq C1 exon
GAGAGGCACGTTGAGCTCTTCCACCGATCTTATGCAGACAGCCACTCCTCTTAACTCTTCGGAAAGCGGTGGCGCAAGCAACTCCGGGGAGGGTAGTGAACAGGAGGCGATTTACGAGAAGCTTCGGCTGTTAAATACTCAGCACGCTGCAGGACCAGGACCACTGGAGCCTGCCAGAGCAGCGCCCTTGGTAGGTCAATCACCCAACCACCTAGGAACCCGATCCAGCCACCCCCAGCTGGTGCACGGTAACCATCAGGCACTACAGCAGCATCAACAGCAGAGCTGGCCGCCCCGTCACTATTCCGGATCTTGGTACCCCACCTCTCTTAGCGAAATACCCATCTCATCGGCTCCCAATATCGCATCCGTTACGGCGTATGCATCAGGACCTTCACTTGCTCACTCACTGAGTCCACCCAACGACATCGAAAGCCTGGCCAGTATCGGTCACCAGAGAAACTGCCCCGTTGCAACGGAGGACATACATTTAAAAAAAG
Seq A exon
AACTTGATGGTCATCAGTCCGATGAAACGGGCTCCGGTGAAGGTGAAAACTCCAATGGTGGCGCTTCAAATATAGGAAACACTGAGGATGATCAAGCTCGGCTCATACTAAAAAGAAAGTTGCAACGCAATCGAACATCTTTCACGAACGACCAGATAGACAGTCTTGAAAAAG
Seq C2 exon
AGTTTGAACGAACACACTATCCAGATGTTTTTGCCCGCGAACGTTTGGCTGGAAAGATTGGGTTGCCAGAGGCAAGAATTCAGGTTTGGTTCTCAAACCGTCGAGCAAAATGGCGTCGCGAGGAGAAGCTGCGAAACCAGCGAAGAACACCAAATTCCACAGGAGCTAGTGCAACTTCTTCCTCTACATCGGCAACCGCCTCTTTGACTGACAGCCCTAACAGCCTAAGTGCTTGTTCCTCGCTGCTGTCCGGATCAGCTGGGGGTCCCTCAGTCA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0005558_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (disopred):
C1=0.917 A=0.831 C2=0.602
Domain overlap (PFAM):
C1:
PF0029213=PAX=PD(6.4=3.7)
A:
PF0004624=Homeobox=PU(29.8=28.8)
C2:
PF0004624=Homeobox=PD(68.4=41.9)
Main Inclusion Isoform:
FBpp0099810

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0088299, FBpp0088300, FBpp0099809
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCCCGTCACTATTCCGGATCT
R:
GTTCGCGGGCAAAAACATCTG
Band lengths:
250-424
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)