DmeEX0008588 @ dm6
Exon Skipping
Gene
FBgn0265487 | mbl
Description
The gene muscleblind is referred to in FlyBase by the symbol Dmelmbl (CG33197, FBgn0265487). It is a protein_coding_gene from Dmel. It has 19 annotated transcripts and 19 polypeptides (18 unique). Gene sequence location is 2R:17216549..17379376. Its molecular function is described by: RNA binding; metal ion binding; nucleic acid binding. It is involved in the biological process described with 9 unique terms, many of which group under: regulation of nucleobase-containing compound metabolic process; reproductive process; programmed cell death; apoptotic process; organic cyclic compound metabolic process. 93 alleles are reported. The phenotypes of these alleles manifest in: fascicle; larva; rhabdomere; visceral muscle; cytoskeleton. The phenotypic classes of alleles include: increased mortality during development; some die during embryonic stage; phenotype; courtship behavior defective.
Coordinates
chr2R:17216549-17276063:+
Coord C1 exon
chr2R:17216549-17217075
Coord A exon
chr2R:17220055-17220103
Coord C2 exon
chr2R:17275410-17276063
Length
49 bp
Sequences
Splice sites
3' ss Seq
CATTCACTTCTTACTTGCAGCTT
3' ss Score
8.63
5' ss Seq
CAGGTAAGT
5' ss Score
10.86
Exon sequences
Seq C1 exon
GCCCGCTTGTGCCGCCGCTTCTGCGATATAGATTCCGATTTTGCCTTCAGTCTCCAGCCGACTTCCTCTACGTGCGGTTCTCAGTCGTCAGTCGCCAGTTGCCAGTCGCAAATCGCAAATTGCAAATTGCAAATCGCCAGTCGCCAGAGTTCGTAGAATTAGAATTCGTTGTCGCGCTTGCAGTTCGCAGTTTGCTGTTCCGCTCAGCTTCTCTCAGCCGGGAGTTATCCTTTCGTCACCATCTCCAGAAAACCAGGTCCTTTCGCCTGTTCGCCTTTCAGTTGCGCGCGCGATTTTATAGCCCGCGATCATTTGCCCGATCGAGTCAAAAATCTGTGAACAAAAAAAAAAACGGTTGAAAAGGGTTAATCCTTTTAGTTTTTGTGGACTTTTAAGTGACGAAATAAAATTGAACCGAGCAAGAGTGACTAGTGACTAGCGCAGAAAAGCTAAAACTTTATGTAATTAAACAACAGGCTTACAATTAGACTCTAAAAAAG
Seq A exon
CTTCCTTTTACGTTCCGCCAACTCTTCGTCCTTCCCTTCAATTGCCCAG
Seq C2 exon
ATAATGTAAACTCAGCTTACACACAAAAAAGCAGTAAAATATAAAATACAAAAATTAACAGCTGCGTTTATCTATAGATATATATATACACATCTATATATTTGAATAAGCGTTCGATTTGAATCAAAATTATAGCCCAAGCTATCAGCTACCCCCACAAGCTTTGTACTCCACAAAAACGCTAACGAGCAAAATCGATAAAGACCAGATAGCAAATGAAATCATACCATCTGCCATAGATCTATGCTATAAACATATATAGGTGCTGATCTGTGCTCTTGAATTTAGTGTTTTTTGTGTGTGCGTGTCGCGAGAGGAGCACTCAAAACCAAAAAAAAAAAAAAAAACGTATAGTAAAACAAAAAACTATCTCTAGTCGCTAGGCTATAACTATACAAACTCCAGCTATCCCAGATCCAGATCCGTAAACAGCAAATAGTTATATATCTATAACCCCAAAATACGATGGCCAACGTTGTCAATATGAACAGCCTGCTCAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0265487_MULTIEX1-1/3=C1-2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
5' UTR
No structure available
Features
Disorder rate (disopred):
C1=NA A=NA C2=0.232
Domain overlap (PFAM):
C1:
NA
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGTGACTAGCGCAGAAAAGCT
R:
AGATAAACGCAGCTGTTAATTTTTGT
Band lengths:
143-192
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)