DmeEX0008589 @ dm6
Exon Skipping
Gene
FBgn0265487 | mbl
Description
The gene muscleblind is referred to in FlyBase by the symbol Dmelmbl (CG33197, FBgn0265487). It is a protein_coding_gene from Dmel. It has 19 annotated transcripts and 19 polypeptides (18 unique). Gene sequence location is 2R:17216549..17379376. Its molecular function is described by: RNA binding; metal ion binding; nucleic acid binding. It is involved in the biological process described with 9 unique terms, many of which group under: regulation of nucleobase-containing compound metabolic process; reproductive process; programmed cell death; apoptotic process; organic cyclic compound metabolic process. 93 alleles are reported. The phenotypes of these alleles manifest in: fascicle; larva; rhabdomere; visceral muscle; cytoskeleton. The phenotypic classes of alleles include: increased mortality during development; some die during embryonic stage; phenotype; courtship behavior defective.
Coordinates
chr2R:17275410-17351264:+
Coord C1 exon
chr2R:17275410-17276063
Coord A exon
chr2R:17276746-17276778
Coord C2 exon
chr2R:17351094-17351264
Length
33 bp
Sequences
Splice sites
3' ss Seq
CACCATCCGAGTGATTTTAGGCC
3' ss Score
-0.29
5' ss Seq
AAGGTAAAG
5' ss Score
9.06
Exon sequences
Seq C1 exon
CCACAAGCTTTGTACTCCACAAAAACGCTAACGAGCAAAATCGATAAAGACCAGATAGCAAATGAAATCATACCATCTGCCATAGATCTATGCTATAAACATATATAGGTGCTGATCTGTGCTCTTGAATTTAGTGTTTTTTGTGTGTGCGTGTCGCGAGAGGAGCACTCAAAACCAAAAAAAAAAAAAAAAACGTATAGTAAAACAAAAAACTATCTCTAGTCGCTAGGCTATAACTATACAAACTCCAGCTATCCCAGATCCAGATCCGTAAACAGCAAATAGTTATATATCTATAACCCCAAAATACGATGGCCAACGTTGTCAATATGAACAGCCTGCTCAACGGCAAGGATTCGCGCTGGCTGCAATTGGAGGTCTGTCGCGAGTTCCAGCGCAACAAATGCTCGCGCCAGGACACCGAATGCAAGTTCGCCCATCCCCCGGCCAACGTGGAGGTCCAGAACGGCAAGGTCACCGCCTGCTACGACAGCATCAAG
Seq A exon
GCCACGCAACTCATAGACATGGACAACTTCAAG
Seq C2 exon
GGCCGCTGTAATCGTGATAAACCGCCGTGCAAATACTTTCATCCACCACAGCATCTGAAGGATCAGTTATTGATAAATGGACGCAATCATTTGGCCCTCAAGAATGCACTGATGCAACAGATGGGCATCGCGCCCGGCCAACCGGTCATATCGGGCCAAGTGCCAGCCGTG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0265487_MULTIEX1-3/3=2-C2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (disopred):
C1=0.232 A=0.000 C2=0.286
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBtr0310346fB958
Main Skipping Isoform:
FBpp0307871
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0086143, FBpp0086144, FBpp0086146, FBpp0297556, FBpp0297558, FBpp0297559, FBpp0297561, FBpp0301759, FBpp0301760, FBpp0302029, FBpp0307872, FBpp0307873
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCAGGACACCGAATGCAAGTT
R:
ATTTGCACGGCGGTTTATCAC
Band lengths:
122-155
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)