DmeEX0008593 @ dm6
Exon Skipping
Gene
FBgn0265487 | mbl
Description
The gene muscleblind is referred to in FlyBase by the symbol Dmelmbl (CG33197, FBgn0265487). It is a protein_coding_gene from Dmel. It has 19 annotated transcripts and 19 polypeptides (18 unique). Gene sequence location is 2R:17216549..17379376. Its molecular function is described by: RNA binding; metal ion binding; nucleic acid binding. It is involved in the biological process described with 9 unique terms, many of which group under: regulation of nucleobase-containing compound metabolic process; reproductive process; programmed cell death; apoptotic process; organic cyclic compound metabolic process. 93 alleles are reported. The phenotypes of these alleles manifest in: fascicle; larva; rhabdomere; visceral muscle; cytoskeleton. The phenotypic classes of alleles include: increased mortality during development; some die during embryonic stage; phenotype; courtship behavior defective.
Coordinates
chr2R:17361980-17373161:+
Coord C1 exon
chr2R:17361980-17362097
Coord A exon
chr2R:17371095-17371153
Coord C2 exon
chr2R:17373077-17373161
Length
59 bp
Sequences
Splice sites
3' ss Seq
AAATATGGTCTCATATATAGCGA
3' ss Score
4.38
5' ss Seq
CAGGTACAG
5' ss Score
8.68
Exon sequences
Seq C1 exon
CAATTCTCTGGCATGGTACCGTTCAAACGTCCAGCTGCCGAAAAGTCTGGCATTCCAGTTTATCAGCCCGGTGCGACCGCCTATCAGCAGCTAATGCAGCCCTACGTGCCAGTCTCAT
Seq A exon
CGAGTCCGAAAATACCCTTGAACGCTTCCTGTGTCATCTACACGGATGCCAGTGGCCAG
Seq C2 exon
TTACTGGACACCCTCCCGGTGTGCCAAGATTTTAATAGATCTATGTGCAGTCGGTTAAATTGTAGATTCGTTCATTTAACTGAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0265487_MULTIEX2-5/6=4-6
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. Stop)
No structure available
Features
Disorder rate (disopred):
C1=0.483 A=0.900 C2=0.032
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0301760
Main Skipping Isoform:
FBpp0086146
Other Inclusion Isoforms:
FBpp0302029
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCTCTGGCATGGTACCGTTCA
R:
AAAATCTTGGCACACCGGGAG
Band lengths:
147-206
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)