DmeEX0008609 @ dm6
Exon Skipping
Gene
FBgn0004456 | mew
Description
The gene multiple edematous wings is referred to in FlyBase by the symbol Dmelmew (CG1771, FBgn0004456). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (6 unique). Gene sequence location is X:13214409..13258490. Its molecular function is described by: protein heterodimerization activity; extracellular matrix binding; cell adhesion molecule binding. It is involved in the biological process described with 20 unique terms, many of which group under: cell adhesion; biological adhesion; cellular process; cell-cell adhesion; sensory perception of chemical stimulus. 46 alleles are reported. The phenotypes of these alleles manifest in: visual system; mitotic domain; organelle; dorsal branch primordium; endocuticle. The phenotypic classes of alleles include: lethal; increased mortality during development; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period.
Coordinates
chrX:13224984-13257183:-
Coord C1 exon
chrX:13256617-13257183
Coord A exon
chrX:13239157-13239225
Coord C2 exon
chrX:13224984-13225111
Length
69 bp
Sequences
Splice sites
3' ss Seq
TTTTTCTTCGTCTTTTTCAGGTA
3' ss Score
14.27
5' ss Seq
ATTGTGAGT
5' ss Score
7.35
Exon sequences
Seq C1 exon
ACGCTATCAATGTCTAATTCTTTACGTAATAATCATTTTTTTTTTTGCTGTGTGACTGAAACGAAGAAATATACGAGCAAAAGTGAAAAATACGTGGACTACCTGTTGATCCAAAGATCTCAACGGATTTAGTGTGTGTGTGTGTGTGTGCGTGCGTGTTTTTTTTCGGTTCATTGTTTTGTTTGCAATAGTGCAAAGGAAAAAGTAATCACTTTGCCGTGTTCGGTGCACGTGCACGAAATATTTATAAAATATATATTAAAAAAAAAAAACATAAAATTAACGATGTTGGAGCTACCGTTTACCACCATACGGCCCAACTGCCGGCTAAGACAGAATCTTGGTATTCTGATAATCCTGCAATGCGTTCTCACTTGCTACAATTTCAACCTAGAACAGCGATTGCCCATTGTGAAGTACGGACATCCGCATTCGCATTTCGGCTACTCGGTGGCCACCCACACTATTGGCGAGGCCAATGGGCCCAACAAGACCAACTG
Seq A exon
GTATGTACTGCTTAACCCATTAGCTGCAGCTGTGCTTAATTAAGGCACAAAATGTTCGGATATCACATT
Seq C2 exon
TGTTTTAGTGGGAGCTCCATTGGATCAAAATCGACAGCCGAACACCACACACTCTGGCGCCCTCTGGCGGTGTCCAATGACACAGCGTTTCGATGACTGCGAACAAGTGATCACCGATGGCAGGCGAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004456_MULTIEX1-2/4=1-3
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
5' UTR
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.038
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0309167

Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0073563, FBpp0302767
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GACATCCGCATTCGCATTTCG
R:
TCGAAACGCTGTGTCATTGGA
Band lengths:
172-241
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)