DmeEX0008808 @ dm6
Exon Skipping
Gene
FBgn0004118 | nAChRbeta2
Description
The gene nicotinic Acetylcholine Receptor beta2 is referred to in FlyBase by the symbol Dmel
AChRbeta2 (CG6798, FBgn0004118). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3R:24509228..24515106. Its molecular function is described by: acetylcholine-gated cation-selective channel activity; neurotransmitter receptor activity; transmembrane signaling receptor activity. It is involved in the biological process described with 7 unique terms, many of which group under: cellular process; biological regulation; cell communication; response to stimulus; synaptic signaling. 19 alleles are reported. The phenotype of these alleles manifest in: chaeta. The phenotypic classes of alleles include: flight defective; chemical resistant; visible; lethal; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period.
Coordinates
chr3R:24514310-24515106:-
Coord C1 exon
chr3R:24514913-24515106
Coord A exon
chr3R:24514494-24514687
Coord C2 exon
chr3R:24514310-24514438
Length
194 bp
Sequences
Splice sites
3' ss Seq
AATTACCACCACTTTCCTAGCTC
3' ss Score
2.49
5' ss Seq
CAGGTAGTT
5' ss Score
6.3
Exon sequences
Seq C1 exon
AACTCAGTTGCGATTGGACTCTCCAACCGTGAGGTTGTATTAAACGGAAACTCCTAGCAAAATGTGTTAAGTTTAGTTAAAAACCTTCAATTATAAGCAATAAGTAGCACAAAAAGCTAGAGAAAACAGCAACAAAATGTGGCATTGGAGTTTGTTGTGTGTTTTCCTACTTGTTCCGTTGGCGAATTCCACGG
Seq A exon
CTCCAATAAGTTTTGAGGCAAATCCGGACACCAAACGTCTCTATGATGATTTGTTGAGCAACTACAATCGATTGATTAGGCCCGTTGTGAACAACACGGAGACCCTGACGGTTTGGTTAGGTCTGAAATTGTCTCAGCTGATTGAGGTCAATCTGAAGAATCAGGTGATGACCACCAATCTGTGGGTGAAGCAG
Seq C2 exon
CGCTGGTTCGACTACAAGTTGCGATGGGATCCAGAGGAATACGGCGGAGTTGAACAGCTGTATGTGCCATCTGAGCACATTTGGGTACCGGACATTGTGTTGTACAACAACTGGGATGGCAACTATGAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004118-'1-1,'1-0,2-1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
PF0293118=Neur_chan_LBD=PU(25.0=83.1)
C2:
PF0293118=Neur_chan_LBD=FE(19.4=100)
Main Inclusion Isoform:
FBpp0084061

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0084062
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCAGTTGCGATTGGACTCTCC
R:
TCAACTCCGCCGTATTCCTCT
Band lengths:
244-438
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)