DmeEX0008926 @ dm6
Exon Skipping
Gene
FBgn0041585 | olf186-F
Description
The gene Orai is referred to in FlyBase by the symbol DmelOrai (CG11430, FBgn0041585). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (2 unique). Gene sequence location is 2R:17843442..17860582. Its molecular function is described by: calcium channel regulator activity; store-operated calcium channel activity; calcium channel activity. It is involved in the biological process described with: nervous system development; calcium ion transmembrane transport; positive regulation of calcineurin-NFAT signaling cascade; store-operated calcium entry; positive regulation of calcium ion transport. 37 alleles are reported. The phenotypes of these alleles manifest in: neuron projection; adult segment; plasma membrane bounded cell projection; cell projection; appendage. The phenotypic classes of alleles include: visible; phenotype; increased mortality; flight defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chr2R:17843442-17851460:+
Coord C1 exon
chr2R:17843442-17843964
Coord A exon
chr2R:17844191-17844415
Coord C2 exon
chr2R:17851058-17851460
Length
225 bp
Sequences
Splice sites
3' ss Seq
TCTTTTGAATTTGTTTCAAGTGT
3' ss Score
4.94
5' ss Seq
CAGGTGAGT
5' ss Score
10.67
Exon sequences
Seq C1 exon
AGAAAAGCGAACGTGTGTGCTCGTCGCCGCCGTGTTTTTCTTGTATTTCCACTATTTTCTGTTGCGTTTCGCGGTCTTCTTGTATCTTTTTTGCATTTGTTCTTTTTTTTTTTTGTTGTTGCTGTGCTTCGAGATATTCTTGTATTAATTTTTATCCGCTTGGCGTGTGTTTCGTGTGGCTTTTTGTGTGCATATTTCTAAGCATCGTAACTGTTTGTTCGTGGGTCTGAAGCATTTCATTTGCACAACAAACAATGTGCAAATATTTGGCCGACATTTGACTACACTAAAATAATTATAATCAGTGACAAGATAAAACCAAAAAAAAAAATAAGCTCGCTGATGAACCGCAGATAAGACGGCGCTCCTCGAAGTAGATCATCTGCATAAACAGCACCCAAAGGAGTGACAACCCAGTCGTCAAGCGGAGACCCATATTTATCACCTTCAGTTAATTATTCGGAACGATTCGCGACGGTTGTGGGTTCCAGCTACATAAT
Seq A exon
TGTCTTAGATGCTTTGCCTATTTATGAAAGTTCCACTGTGTTGGTGTTATGATGCGATGGCATAGAAAGTGCACTAGCTGAAGCCGGAAAAGTTGCCAGAACGAACACGTGCTTAAAACAAAAAAAAACTATAAATAGCAACTAACAACAAACTTTAGCCTATCGTTAGTGCCTAATTTATAGTTAAAAACCAAAAATAGTGTGACTCGGCCAGCAGAAATACAG
Seq C2 exon
ACGTACTTAAATCCGCAGGAGAAATCGCTAGCCAAAAATCATGTCTGTGTGGACCACGGCCAACAATTCGGGCCTAGAGACGCCAACAAAGTCGCCGATCACGTCGTCGGTTCCGCGGGCAGCGAGAAGTTCTGCAGTGATCACCACTGGAAATCACCAGCAGCACCACTTCCAGCACGTTGTGGCCGCCGCCGTTGCAGCCGCCACTTCAGTGGCCACCGGTCATCAGTTCCAGCAACAGTTCCCGCTGCACGCACATCCGCATCCACAGCACCACAGCAACAGTCCCACGGGTAGCGGCAGCAACAGCAACAACAGCGCAGGTTTCCAGCGCACCAGCATCAGCAACTCGCTGCTGCAGTTCCCGCCGCCCCCGCCCCCTTCCTCACAGAACCAGGCGAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0041585_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
5' UTR
No structure available
Features
Disorder rate (Iupred):
C1=NA A=NA C2=0.975
Domain overlap (PFAM):
C1:
NA
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ATGAACCGCAGATAAGACGGC
R:
TCACTGCAGAACTTCTCGCTG
Band lengths:
298-523
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)