DmeEX0010025 @ dm6
Exon Skipping
Gene
FBgn0034013 | unc-5
Description
The gene unc-5 is referred to in FlyBase by the symbol Dmelunc-5 (CG8166, FBgn0034013). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is 2R:15340472..15368300. Its molecular function is described by: netrin receptor activity involved in chemorepulsion; netrin receptor activity. It is involved in the biological process described with 6 unique terms, many of which group under: multicellular organism development; anatomical structure morphogenesis; developmental process; regulation of locomotion; plasma membrane bounded cell projection morphogenesis. 29 alleles are reported. The phenotypes of these alleles manifest in: plasma membrane bounded cell projection; cell projection; dorsal vessel primordium; visual system neuron; filopodium. The phenotypic classes of alleles include: increased mortality; cell migration defective; phenotype; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages.
Coordinates
chr2R:15360415-15364641:+
Coord C1 exon
chr2R:15360415-15360468
Coord A exon
chr2R:15361983-15362300
Coord C2 exon
chr2R:15364513-15364641
Length
318 bp
Sequences
Splice sites
3' ss Seq
CTCTGCTCTTCCATTTACAGTGG
3' ss Score
10.21
5' ss Seq
ATGGTAAGT
5' ss Score
11.01
Exon sequences
Seq C1 exon
AGGACACTCAAATCGTGAGCCCTGATGGATTTGACATTTCGTCGAGTAAGCGCA
Seq A exon
TGGCCCGCTGGTCGGCGTGGAGTGACTGGAGCATCTGCTCCGCGGAGTGCATTCAAGTGCGTCGCCGGAAGTGCCTGACTCAGGGCCAGACTCAGATTTCCTCCGAGGCGGAGGAAGCCGGTGATCTGCTCCTGGGAGCTCCCGGAGTGGGCATGGCCGCCCTCATCGCCGCTGCAGGAGTGGGCGCAGTAGGAAGCCCCAGCGAAGCGACTGGCTCCAGTTCCGACATTATCCCGGGATATGGCAAATCATTGTGCGCCGGAAAAGACATACAAACGGCCGAATGCCGCGGCGAACAGTGCCAGATTGGCAAGGATG
Seq C2 exon
ATTTCGATTGGACCCTCTATCTGGGATTGGCCTTCATAACGGCGGTGTGCTTCGCCTTCGGGACCGCACTGATCTGCTGCGCTCGCCGTGGCATCCGCACCAATCCCCATTACAACATGGCCCGTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0034013_CASSETTE2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.105 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
PF0009014=TSP_1=WD(100=34.6)
C2:
NO
Main Inclusion Isoform:
FBpp0086514
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0309017
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)