DmeEX6015617 @ dm6
Exon Skipping
Gene
FBgn0003149 | Prm
Description
The gene Paramyosin is referred to in FlyBase by the symbol DmelPrm (CG5939, FBgn0003149). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (3 unique). Gene sequence location is 3L:8732858..8745310. Its molecular function is described by: motor activity. It is involved in the biological process described with: myofibril assembly; mesoderm development; actomyosin structure organization. 21 alleles are reported. The phenotypes of these alleles manifest in: myofibril; somatic muscle; striated muscle myosin thick filament; sarcomere; trichogen cell. The phenotypic classes of alleles include: visible; phenotype; increased mortality; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes.
Coordinates
chr3L:8742337-8745310:-
Coord C1 exon
chr3L:8744963-8745310
Coord A exon
chr3L:8744275-8744331
Coord C2 exon
chr3L:8742337-8742423
Length
57 bp
Sequences
Splice sites
3' ss Seq
TATCCACCATTTTCTTGCAGGAC
3' ss Score
9.99
5' ss Seq
AGGGTGAGT
5' ss Score
9.25
Exon sequences
Seq C1 exon
AATACTCTTTATTCGAACGACAACGGGATCTCTTGTTCAGTAGATCACCAGCCTTACTCCGACGTTTATTACGAATTTTCTCGGTGACTCGGTGACAACTACAAAACTGCGTGCGGTGCTGTATAGATTTTCGCTTGAGAGGAACACACAAATCATAATACTAGATACGCGAACCGATCGCACATTAATTTATAGAACCAAAATCGAAAATCTGACCTAGCAAACATGTCGTCATCGCAGGCTGTCCGCTCCTCGAAATACTCCTACCGTGCCACGTCCACCGGACCCGGTACCGCCGATGTGAACATCGAGTACATCCAGGACCTGAGCTCGCTCTCCCGCTTGGAG
Seq A exon
GACAAGATCCGTTTGCTCCAAGATGATCTTGAAGTTGAACGTGAGTTGCGCCAAAGG
Seq C2 exon
ATCGAGCGCGAGAAAGCCGATCTCAGCGTTCAGGTCATTCAGATGTCCGAGCGTCTCGAGGAGGCCGAGGGTGGTGCTGAACATCAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0003149-'2-1,'2-0,5-1=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.463 A=0.000 C2=0.276
Domain overlap (PFAM):
C1:
PF0157614=Myosin_tail_1=PU(4.7=97.6)
A:
PF0157614=Myosin_tail_1=FE(2.1=100)
C2:
PF0157614=Myosin_tail_1=FE(3.3=100)
Main Inclusion Isoform:
FBpp0076320

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0076321
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCTGTCCGCTCCTCGAAATAC
R:
CTGAACGCTGAGATCGGCTTT
Band lengths:
141-198
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)