Special

DmeEX6024894 @ dm6

Exon Skipping

Gene
Description
The gene eyeless is referred to in FlyBase by the symbol Dmeley (CG1464, FBgn0005558). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 4:697689..721173. Its molecular function is described by: RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding. It is involved in the biological process described with 19 unique terms, many of which group under: growth; sensory system development; post-embryonic development; sensory organ morphogenesis; cellular response to stimulus. 86 alleles are reported. The phenotypes of these alleles manifest in: medulla; cellular anatomical entity; eye disc; hemolymph; visual system. The phenotypic classes of alleles include: increased mortality during development; increased cell death; phenotype; visible. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages.
Coordinates
chr4:704651-711082:+
Coord C1 exon
chr4:704651-705273
Coord A exon
chr4:707492-707671
Coord C2 exon
chr4:710917-711082
Length
180 bp
Sequences
Splice sites
3' ss Seq
TTTGATTTTCTTTTTTATAGACA
3' ss Score
8.21
5' ss Seq
AATGTACGT
5' ss Score
6.58
Exon sequences
Seq C1 exon
CGTATTAATCTTTATATCAAATGAAATTACCGGCTAAGTTAGCAATCGGTAGACCCGGGAATAATACGTGTTACGTGCAGTACAAATATGATGCTAACATGAGTGCAATCAAAAGTGGCGTTCGAAAAATGAACAAGTGAACTAAAACAAAAGCGGCTGCTCAGTTATATTTGTGTTTCCGAATTCGTAACTCTTAGGTCCTCACGGCGCGATCAACAATAGGTTTTTTGATCACTGCAGGACGTCATTCTCACCATCTGCGCAAATTTACTCTTAACTCTTGCTTGACTCGCCCTGCAAGAGTTCGCACGGCGTGCGTTTGGCTGAACACAGCAGTCTCTTGGCTAAAGCTTTCATGAGCAGTGCATGTAATAAAAACTGAGATCCAACTATGTTTACATTGCAACCAACTCCAACTGCTATAGGCACCGTGGTTCCCCCATGGTCAGCGGGAACATTGATAGAGCGCCTGCCGTCTTTAGAAGACATGGCTCACAAGG
Seq A exon
ACAATGTGATTGCAATGAGAAATTTACCCTGTTTGGGTACCGCTGGTGGTAGCGGACTAGGCGGTATTGCTGGGAAACCTTCCCCTACTATGGAAGCCGTGGAAGCCAGCACAGCGTCACATCCCCATTCGACATCTTCATACTTCGCCACAACTTACTACCATTTAACCGATGATGAAT
Seq C2 exon
GTCACAGTGGAGTAAATCAGCTGGGTGGCGTTTTTGTTGGAGGAAGGCCTTTGCCAGATTCAACACGGCAAAAAATTGTCGAACTGGCACATTCTGGAGCTCGGCCATGTGATATTTCTCGAATTCTGCAAGTATCAAATGGATGTGTGAGCAAAATTCTCGGGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0005558-'1-5,'1-4,2-5=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (No Ref)

No structure available
Features
Disorder rate (disopred):
  C1=0.595 A=0.605 C2=0.225
Domain overlap (PFAM):

C1:
PF0029213=PAX=PU(0.1=0.0)
A:
PF0029213=PAX=PU(0.1=0.0)
C2:
PF0029213=PAX=PU(44.0=98.2)


Main Inclusion Isoform:
FBpp0099810


Main Skipping Isoform:
FBpp0088300


Other Inclusion Isoforms:
FBpp0099809


Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGAACACAGCAGTCTCTTGGC
R:
CGTGTTGAATCTGGCAAAGGC
Band lengths:
243-423
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)