DmeINT0019372 @ dm6
Intron Retention
Gene
FBgn0000157 | Dll
Description
The gene Distal-less is referred to in FlyBase by the symbol DmelDll (CG3629, FBgn0000157). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 2R:24814822..24835667. Its molecular function is described by: sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with 16 unique terms, many of which group under: organic substance biosynthetic process; positive regulation of biological process; nervous system development; central nervous system development; clypeo-labral disc development. 44 alleles are reported. The phenotypes of these alleles manifest in: lobe system of mushroom body; larval maxillary segment sense organ; macrochaeta; hindgut; female genitalia. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; lethal - all die before end of larval stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period.
Coordinates
chr2R:24833797-24835667:+
Coord C1 exon
chr2R:24833797-24834013
Coord A exon
chr2R:24834014-24834153
Coord C2 exon
chr2R:24834154-24835667
Length
140 bp
Sequences
Splice sites
5' ss Seq
GACGTGAGT
5' ss Score
9.22
3' ss Seq
TTGATCCGTTTAACACACAGTGT
3' ss Score
5.5
Exon sequences
Seq C1 exon
AATTCCCACCAACGGGCCTCAGTCCGCCGACGCAAGCGCCGTGGGACCAGAAACCGCACTGGATCGACCACAAGCCGCCGCCCCAAATGACGCCACAACCACCTCATCCAGCGGCAACGCTACATCCGCAGACGCACCACCACAACCCGCCGCCCCAGATGGGTGGCTATGTGCCCCAGTACTGGTACCAGCCCGAGACGAATCCATCACTAGTGAC
Seq A exon
GTGAGTTTCGAGCCCGATATACCGTACCCAGTTGGCTGTAAACGATGAATCAGCCCGTTTACCACCAGCTCCAGCCCTCATCCCCCTTTCGAAGTCTCCTAACCCCGCTATGGGGTTCCCTTGATCCGTTTAACACACAG
Seq C2 exon
TGTTTGGCCGGCGGTCTAACAGCATCCGAACCAGCTGCCCTCGGCTGCCTGGACGCAGCACCAGCTGAGCCTGGAGCAGCAGCACCAACACTCCTGCCAGGAGCTGGGGCACCAACTGCAGCTGGAGCAGCTCGAGCAGCAGCACCAGGCCCAGGCGGAGGCCCAGCACCTCCTCCAGCGGCAGGACCTCGCTGGCAGGACCTTCGGGGGCGGGGCAGTGCAGCACACGATATCTTAGCCAATAAACAATAAACAACCATGATAGCAACCTGTAAAATATCTATGAAATGTCGAGAAAGAAGCGAGCGAGAGCACTGGCAAGTTAGGCGTCAAGTTTTGTACATTTGAAACGTAATATAAATATGTTTACCAACGTAAATAAAGTCGTTCTAAAATGTAGTCTAGCTAAGAAGAAATCGAAAACACACACACACACACACAAACAACACAAAAAGAAAACAAAAAAAAATACTTAAAGCAGAGAACATTCCTCAATCACAGAAGCAAGGAGAGAGTATGAAACGTGTCCTTTAATTTTGTTTAATTTAGCAAATTAACTATGTATAAACCTATCTATATGAACGTAACTATATGTAGTGAGCAACAACAAAGTATAAATCGTAAAAAGTACATCGTAAATAAATGAAATCAAACAAATGAAAATCAGCTGTTGATCTTAGAGTTTCTTTCGAGTGATTTGTTCTTAAGTAGAAGAGTCGAAAAAAGGCAAAAGAACGAGCAACAGAAATCAGTAAAATCAGATCTCAAATGCAAAAGGAAAAGTCCTCCTAATTCATAAATGCCCTTTAATTTTTTTGTATTTTATTTTACCTGCACCCAAAAGAGGAGACCGGTTTCGTTCTTTATTGTGCAATATAATCTTATTTACCAACCTGTTGGGCGTTAACTAATTGCTTGAAGTGTACATTTTGTATAGACCGCATGCAGAATCAAATGTGTGCATCAAATGTCAAGGGATCCCATTTTAACAATCGAATCAAGGCGAATTCAGATTCAGACTCGAAATTCGACTCGCTGCTGAGCTTGCTGTAGCTGTAATTATGGATTAACATAATCTAGTTTAAGTGGTAATTAGTGCGTGTGTTTCACCCTAGTTTAATTTAACCACAGCAAGAGCTAAAGGAAATAATTGATAGTTTACCAACTAAAGTGCGAGTGAGTGCGTGGTTGAATTTATGAATCGATAAATATTCGAGTGGATGAGTGAGTGTATGTGTGCGCGATTGCAATGTAAACAAAACAATAAAGTAAAACAAACACATGGCAAATTCGAACGAAATCAAATTAATGAGAAATGCATAAACAAACCTTATGTGCTAGCATTTAATTAATTAGTTGTAATCTAGAAAATGGCAACACAAATCACTGAAGAGCCTAGCGACTCCCCTCCCCATTTAAATTTTAGCAACTAATGTAATTTTTAAATCAAATCAAACAACAGAAAAAAGCGCGAAGCCTCAATAAAAATAAAGAAAATTTAAATATAAAACAAC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000157:FBtr0072379:6
Average complexity
IR
Mappability confidence:
NA
Protein Impact
Alternative protein isoforms
No structure available
Features
Disorder rate (Iupred):
C1=0.934 A=NA C2=0.833
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0072286
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CACTGGATCGACCACAAGCC
R:
CAGGAGTGTTGGTGCTGCTG
Band lengths:
257-397
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)