Special

FBgn0000157 @ dm6

Biotype
protein_coding
Gene Symbol
Dll
Description
The gene Distal-less is referred to in FlyBase by the symbol DmelDll (CG3629, FBgn0000157). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 2R:24814822..24835667. Its molecular function is described by: sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with 16 unique terms, many of which group under: organic substance biosynthetic process; positive regulation of biological process; nervous system development; central nervous system development; clypeo-labral disc development. 44 alleles are reported. The phenotypes of these alleles manifest in: lobe system of mushroom body; larval maxillary segment sense organ; macrochaeta; hindgut; female genitalia. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; lethal - all die before end of larval stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period.
Coordinates
chr2R:24814822-24835667:+
Assembly

GENOMIC BROWSER[edit]


EXPRESSION VALUES[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Intron Retention
2026
chr2R:24815568-24817593
+
6.46
58.82
0
Intron Retention
66
chr2R:24833731-24833796
+
16.3
99.28
0
Intron Retention
140
chr2R:24834014-24834153
+
44.16
100
0



Orthologous genes[edit]

Organism Assembly Gene ID Gene Name Orthology Type

Human hg38 ENSG00000108813 DLX4 1-to-1
Human hg19 ENSG00000108813 DLX4 1-to-1
Mouse mm10 ENSMUSG00000020871 Dlx4 1-to-1
Mouse mm9 ENSMUSG00000020871 Dlx4 1-to-1
Rat rn6 ENSRNOG00000001520 Dlx1 1-to-3
Rat rn6 ENSRNOG00000004399 Dlx4 1-to-3
Rat rn6 ENSRNOG00000010822 AABR07059679.1 1-to-3
Cow bosTau6 ENSBTAG00000007353 DLX4 1-to-1
Zebrafish danRer10 ENSDARG00000011956 dlx4a 1-to-2
Zebrafish danRer10 ENSDARG00000071560 dlx4b 1-to-2