DmeINT0019658 @ dm6
Intron Retention
Gene
FBgn0000581 | E(Pc)
Description
The gene Enhancer of Polycomb is referred to in FlyBase by the symbol DmelE(Pc) (CG7776, FBgn0000581). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (4 unique). Gene sequence location is 2R:11452043..11465270. Its molecular function is described by: histone acetyltransferase activity. It is involved in the biological process described with: dendrite guidance; regulation of transcription by RNA polymerase II; histone exchange; chromatin organization; histone acetylation. 25 alleles are reported. The phenotypes of these alleles manifest in: external sensory organ; external sensillum; tergum; adult neuron; posterior crossvein. The phenotypic classes of alleles include: phenotype; increased mortality; neuroanatomy defective; modifier of variegation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chr2R:11456805-11460319:+
Coord C1 exon
chr2R:11456805-11456920
Coord A exon
chr2R:11456921-11456987
Coord C2 exon
chr2R:11456988-11460319
Length
67 bp
Sequences
Splice sites
5' ss Seq
CAGGTTTGT
5' ss Score
7.44
3' ss Seq
AAATCGGGCTAATTTTACAGACC
3' ss Score
4.56
Exon sequences
Seq C1 exon
ACTCGACAACGAGATGGCCGCTATCCGTGGGACTCAGCCGACGAGGATATGGCGCCCAGTGGTGCTTGTTCGGATGCTAAATACCGTTACACACTGACCTCCCTCAATTATCCCAG
Seq A exon
GTTTGTTGCCATTCTCTTTGGCCAATGTAAATGCCCATACTCACTCCAAATCGGGCTAATTTTACAG
Seq C2 exon
ACCACGCTGCATTGGCTTCGCACGTCGTCGATTGGGTCGTGGCGGTCGCATCCTGCTGGACCGGGCCACAACGAATTTCGACGACTTTTGGTCGCAGCTTGACTACACGGTGATGGAAAGCGTGACGGTCAACAAATGTAGGGATAAAATCAAGCAACGGGATCCCGATCAGCTGTGCAAGCCCAGCTCACCGCCCACGGTGGTAGATCTGGTTCCCGCTGGAAAGCCCGTCGATGGTGAGCATCCTGTTCCTGAACTGATAAAGGAGGAGCCGTCAAGCGATACAGAAAAGCCTGTTGCTGCGACGGAATCTGGGCGGGAGAGCAAAGAACGGGAGCTTGAGGAGAAATTTGAGAACGATGTAGATGATGAATTCGTAGCCAGTGACGATGAGAATGTGTCACGGCTTGGAATCTACAGTTCAGCGGTTACGTTACCCCAAAGTTGTGCTGATCTTCGCCAGAAACGTCGCCGCCTGCGTCGCAAGAAGCAACAGTTGCGAGAACTTAATGCCGCAAAGCGTCTAAAGAGGTCTTCGGAAGCGGTGGCAACCGCTGAAGATGTTCAACTGGAGGACGAGGATACTAAACCAGATCTGCGTCCATTACCCAGGGCTTACCTTCAGCGTTTGGCATTGATTCTGGGACAAAAACTAAAGGTGGAAGAGGATGATAACACGGAAGTTTCCGAGAATGTGGCGCCAGAGTTGCTGGAAATGAATGATCCGGAGCAGCTGCAGCCCCCGCGAGCCAATCATCAGCAACACCACCGTTCCAACCACAACAACAACAACAATACCGTGTTGAACAACAACAATAGTAGTAGTAGTAACGTTATGAATAAGGATGTTAGCATTAGCGAAAAAATCAATGTGATAAAGCAGGAGGCGGAGGAGCTCGTCGGCGGCAAATGCGAGGATCAACCGGTAGCTTCCACCTCGGCGGCAGCGGCCGCCGCTCGTGCCGCTGAAGCAGCCGCTGCAGCGGAGGCAGCCTCATCGACAACCACTCTTGCGGCACCGAATCCGGGTCCATCGCTGGAGGAGGTGGCGAAGACGATAAAGCGCGAGATGATCGATGCCGACGACTCCAACGAGCCCCTGAGCAGCATTCGTACAGCAGCTGTCATGCTGTCCACGCAGACCTCTGTCTCCGAACTCATGGACGATGAAGCTGAGGACGATGTCAATCTCGCCCAGCTGAGCAGTATCATCCGGCATACGGCGGTCAAGAAGGAACTGGAGGCCCAGCAGCACCAGCAACAAGTACAGCATGAACAGATGCAGGCCGCCAGGAAGATGGAAGAGGATGAAGCCGCTCCCTGTCTGAACCAGCTGCCTGACGTGATTCGCTTGCGAAATATCCGCAACAGCCAAGTGCATGCGAGGCCGAAGGACCTGTTTGTACAAGCTCCTGTTGATGAAGAATTCAATGCAGACTACATGGGTGGACTGTCGCCCACTTCCAGCCAGCGGCTAGACATCTGCAATGAGCTGCTTTCGGAGATCCGGCGCGATTGGCTACACTTCCGGCCCAAAACTCCCACAGATGAGCTGTCCGATAGCCAAGATTGCGAAGTGGGTAAGACGTGTGATAGTCACGCTGTCGACTGGACGCAGGACACGCCCATAAGTGTGGAACTCAATCGCTTAGGAAAGCGAGAAGCAGAGGAAAGCGATTCTAGCTCGTACTTTTTGAGCAGTGGCTTTAAATACAGGGATCTCGAGTCAGATGCCCAATTGCTGCAAACGGTCCAAGCTCAGGACTACGCTCGAGGCAGCAGCAAGAGTCCAAACTGCTCTGGGTCAGGCTCAGGATCTGCGCTAGAGTTTAATCTCAGTGGTGGTGACTCCCTAAACGATATCAACAACTTGTTGGGCTGTGACGACGAGGACGACAACCACGAGCATATGCTAGACAACATCCTGCAGGAGTGCGCCATGGATGATCCCAAGGCATTGAACCAAGCTACTAATTTTTGGAACGGTATCCTAGATGGCGAGGCAGCCGTGGACGAAGTGGAAATGGCCGATCAGCTGTTGGATTGTATAGACGAGAAGAAATCTAAGGTGGGTGCAGCCGATACATCGAAGCGCGCGGGTCGCAACCGCAAGGCAAGATTGATCCAAGCTCCAGTGGGTAGCTCCGCATTTACTGTGTGTCCCACGGCGGAGACTCTGAAGGAACGTGAACTTTTCTTTAGTCAAGCTCCGCCTGTTGAAGTCCCGCCCAAAGAGAAAACGCCAGCAGAAGTTGAACTGCCGGAAGTTGTGGTCAAGGAAACAGCGAATTTGCCTGTGAAGGTTGAGGCGGTTGAGAAACCCCAGTCGGAGGTTCTTCCCGTTGCCCCACAGCCGCAACAGCTTCAGCCGCAGGCTATTACTTTGCCCACGACGCAGCTGATCAACATACCCGCCCAGATAAGCACGCAAAAGCAGCATCAGCAGCCACAGGTGACGCAATTGCTCAATCAGTTTGCCAACGCTGGTCCGCAGATCATCGCCCGCACAGAATACGGCGGAGGAGCAGCTGTGGGCGATATAGTGACCATAACCCCGCACACGGGGAGCAGTCCACTCCCCACACTCACCGCCCAGCAACAACTGCAGCACCAATTGGCACAGGCTCAACTCCGAAATGTGACCGTCCAGCAGCGACAGGCGACACCTCAAAACCCCAATCAAAATCAGAATCCCCAGCAGCAGTTACTCTTCCAAATGCAGCGGGATCCCTCGCGCTCCCTGACGCCCCTACAAGCTGCCGGCGCTGGCGCCACTGGCAACCATTTGATCTACACAACAAGCTGCGGCGAGATTGTCACAGCAGGAGCTGCAGCTTCTGCGTCTCAGAAGGTCACATATGCCATCCAGAAAGCCGGTGTCTCAAGTGGAGGAGCAACCACCGCCTCAATTGGACCCAACACAGTAATCACGCTGTCCAATGTAAAGGTGCAGAACGATGATATCTCCTCTGGTGGTAGTGGCAACTCAGGATCCAGTGTGAACATCATCAACACGGCCAGTGGCCAGCAGTTAGCCGTGCACAGCATTGCCGGTATGCAACAGCAGGGCCAGCAACAGGTGCAACAGGTGACCACCAGTACGCCTTTGCTTGTCGCCACACCCACTCGCAACAATGTGCAGCAGCAACAGCAGCAGTTGGTGCAGCAGCAACCGATTGTTTGGCGGCAGGTGAGCGGAACGAACACGGCGGTGGCCACCACAGCAGTGCTCTCCACCACGGTGGACTCCTCGCCGAAGGCGGTAACCAACCAGATCCTCTGGACCAGCCGGGCCACGCAAAAAAGGCAGCTCAACGGGCCAGAGAACACAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000581:FBtr0088139:9
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.333 A=NA C2=0.579
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0303472
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0087238, FBpp0087239, FBpp0303471, FBpp0303473
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GTGGTGCTTGTTCGGATGCTA
R:
CACGCTTTCCATCACCGTGTA
Band lengths:
182-249
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)