DmeINT0019906 @ dm6
Intron Retention
Gene
FBgn0011589 | Elk
Description
The gene Eag-like K[+] channel is referred to in FlyBase by the symbol DmelElk (CG5076, FBgn0011589). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 2R:17873939..17926695. Its molecular function is described by: voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: regulation of membrane potential; potassium ion transmembrane transport; potassium ion transport. 15 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: partially lethal - majority die; some die during pupal stage; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.
Coordinates
chr2R:17903542-17907906:+
Coord C1 exon
chr2R:17903542-17903679
Coord A exon
chr2R:17903680-17907646
Coord C2 exon
chr2R:17907647-17907906
Length
3967 bp
Sequences
Splice sites
5' ss Seq
GCGGTAAGT
5' ss Score
11.37
3' ss Seq
TTTTGTTGCGACTCTGTAAGTTT
3' ss Score
1.53
Exon sequences
Seq C1 exon
GTGCCCCCTTCTGGTGTTTGTTCGACATTGTGCCCATCAAGAATGAGAAGCGCGATGTGGTGCTCTTTTTGGCATCCCACAAGGACATCACGCACACCAAGATGCTGGAGATGAATGTGAACGAGGAATGTGATAGCG
Seq A exon
GTAAGTATAAGCAACTGGTATGAATAATGCACTAGCTAAACACCAACTGTCGAAAATCCAAGCGTGCACAAAAGCCACAGAAACACCCACTAACACAGACACACACGCAGACACTCAATTCCCATATAATAAATTAATAAGCACCGACTCATAAGCCAAAACACACTGACACTGATGCATTCCCTCAGATATAGGAAGATATGGCCAAATATCATGAACCGGTTAGCCTCTCAGCTACAGAAGTTGGCTGAAATATTGTGACATGACTGCGGCAAATTTGCGAATAAATATCAGAGGATACACTCTGTGAGATCCAAGTATATTTAAAAATATAACACAATTCCAGTTGTTATATGTTATATTAACTTAACTTCAAAAATGAAATCAACATATTTATAAACTTTACTCCCAGACTTTTAGCCAAGTAAATGCAAAAAAATAGCTTAAAAACATAAAATTTTGCTGTTCAGCAAATAAGAGAATGTGGTCTTAAGCTGTGACAATAAATCTGCGTGCAGAGTATTCCACAGTCAAGAGCCATAAAAATTGTGTGAATGCTACCTTCATTCGAGCTATGTCAGCATGTCACCTCAACTCTCGGCCAGAAATATTCCTATAAAGTTTTGCGGAACTTTTGGTTTCGCTTGCTCATGGCAGAGAGAGTTTTTGGTTAGCTTTCTGGCCGAGATGGCGGGCAGGAAGGAAGGAAGGAAGAAGGCACTCCGACTGGCTGTGGTCGCTCCTTTTGAGTCCTTTGCCGACTTTTCATCCGTTTCCCCCTTTCATTTCACCAGCGCGTGTCCCTGACAACTGGATGTATGCTTACCATATTTCAACGTTAATTTAAATCTCGTCTTTCATGCGCAGTTTTCGTCGTGTCGGCACTGATTTGTGGCTATAATCTGGTCGATAAGCGGCTAAAAACTTCATGAATACGTTATGATAACATTTGCAATCAGTCGCATTTCATATTCGCACTTTGGCTAAGAACCAGTAGAGAGAAACTAATCTTTTACATCGATAGTGGCTTCCGGCGAAGTTCTACTAACGCATTTACCTTAATTAACTCGCACCAAATGTCCTTATTTTCTTTTGTTGCTACGAGTCCTTTTGCTTCTCTCGCTGAGCCACATCAAATTTGCCCTCTGTCTAATTTAGTGGATTAATCAGACAAAAAAGTTGGACACACCGGCGGCACACGTGTGCTGGCTGGATCCCCAAAGGATCCAAATGCTAAAATATTGATGCACCACTCGAACAGTTCTGACAGCATCACAACTTATTCCGGGCACTTTGGCCATTCGGTACTCGGAATCGCATGTGTCGCCGTGAAATTCTGCTAATGCAGGGATAAAAAACAGCTACCGCCCTCAACCCTCAATCCCACTATGCCCCAACCATGCCCACTGACCTTCTGGCCTGCAGCTTTATTACCATCGTTATTCATCTGTTGTTGCCGTCTGTTTGCCTGTCTTCTGGCCTGCAGATTTACGGGTCATGCAAACCGAGCAGAAGCCACTTGAAGTTCGACCAGGAGAATCCTAAGAGGATTTGCTGCACTGCATACTCGAGTGTCAGGCCGGCAGGACCTTCTGTTCCATGGACAACCTGGCATTGAAGCTTTAAATAATTTAGTGCTCAGAGTATTGATATGGATGGGACTTTAAATGGGGAGTGAATTGGGATGAGTTTGTATTGGCAGATGCAAATTTAGTAGTCTATTTATAGTCTATTTTATAGCATAATAAGGATACTTAAACATTTTTTCTTTCTAATTATTTTAATTGGTATAATTTTAGTTAGTTATAATTCATCTACTGCTGCTTTCGTTCTATATACCCCACATGCATTCCGCTAACGGGGTATTGCAATTCACACCAAATGCTTGGCAGATGTTGCATGTTTCGCACTTGGATTGCAAGTGCCACAAACACCTATTGCACTTGCAACACGCACTTATCGCCCCCCTGTTACCTGTCGTCGAGGACTTGCCACACGTAATTGTGTTAAATAGACAGAGATTTACATGACGGGCAACATTTGGTAATGAATTTCATTAACTTGCTCATTGAGTGGCAGCCAAGCAAATATGGCCAGAAACCAGTTAAATGTAATGCAGTTTATATCGAATTAATCTACACTCAAACCAAAGCAGCGGCCGAGCCTGATTCAATTTTTGTTAATTTATGTAAATGAAATTAGGTCCGAGCCAACCAACCTTGGCAAAACCAATTTCCAGCTGGAATCAAGCTGGCTGGAAAACTTGAATGCCGATCTCTGTCAATGGGAAATTAATGCCGTGACAAAGGCAAAATTTGGGTTTAGCCATTGAGAACTGTGAAGACAGCTAATTAGGCGAGCAATTTTCCAAAATTTGTGATAAAGCACATTTTGATGAACCCGAATTTGAAATGGAATTATCATCAGATCATAATCGTTATCGCATTGTGACGACAGTTATGCGATGATGACCATCGTTTCACACGTCATTAGGCCTGTCAGTGAATTTTCCCCTTCGGTTGCCAATGAGTTGTGCATATTTCGTTAAAGCAATTCACATTTTTCAATGGCACTGTGCCAACAGCGATAAAAAACATTTGTGTATGCATGAGGTCTTTTTTGTATCTTTAATTTTTTCCCTGACCTTTTTTTGTATAATTTCTTTTTTTTTTATTCAACGGCTGTTGCTCGGTTACGGATGAAAAGTATATGTATCGGTGAGGTGACCGTCCCGACTTAATTGGCATTTTGATATGACAGCAAGGGAGTGAAACTGGATTTTATGTGGGTGGCGGGACATAACATTGGAATCATATTTTGGTCAAAAATTGTTCATGTTAGCTACATACATATATATAGAAGGGAAAATGAACGAAATGAAAACAGGAAAAACGGAGCGAAATTGGTGTGGAAAAAATGGCAACATTCTTGGCGGCTATTTGCATAATTTTCTTTGCTGTTTTTGTGTATAATTAGTACACGTTTGGGTTGCGAAACGTATCAAATTCATTTTTGGGTCCATTTTTCACCATCCAGCTAATTGTTATTTATAGCATGTCCTTTTTAGACACCACACTCAAATAGAATTAAGTTCAATTTAATGGGCACTTTGCGGTGCCAAATATGCGCTACTTTGAGCTTATTTTGTTCGAGCTTTGTTTGTTCGGCTGTGAAATATGATGTTTATTCGCCTGATTTGTTGGCCTGGTCAGGACTTAGCCAATATTTGTCGGCCGCTGAGGGCGATTATTAATTGTTTGTCAATGCTGCGATGCTTCAGTATCGCAAAGGTGACAGTAAAATAATGTAATACGAGTATTCTTACGAAAAAGATTTAAGCACATGCAACGAAGGCAATACTTTTGGTCAATTAAACTGTGTTTTTGCAATTTAAAAGTTTTTCAAATAAAACTGAGCAAAAACAATAAAGCAAAGCCTGCGTTTAGTGAGCAAACTTTCTTGTGCTAATGCACAAAAGGCTAAAACCATCTGTAAAAGTTGAGTTTTCATCTTTCCCTCCACTAAGCTGCTCAAATGAAAGTCAGCAAAAATAATAAATGGAGTCGGTGGAAAAGCTGTATTTAACTTGTCGGAAAGTCGACAAAATTCATGAAAATCTTTTGCGAGACAAGGTAAATTCTGAGGGAGTGCATACACCACATACACCTGCAATTTTGTGACGCTTTAAAAACGCGTGTTTTAAATCAAACGCAATGCGCTTTAACTAAGGAGAATTCAAAAAAAAAAAACAACAATTTAAATTAACCATGCCAATTAATTCATAACGTCTTATGTGTCAAATTCTGTGTTCTTTCTCTTTGTGCTCTTTCTATTATAACAAACACACACAAATCGATCCGGTAAATCACTGTAATTACGAACCGCCAAACCTGCCCGCCCATCCTTAATTATCCTTTGCCACTGCCTGGTTTTGTTTGCGTTGCTTGTTTTGTTGCGACTCTGTAAG
Seq C2 exon
TTTTTGCCCTTACAGCTGCCCTTTTGGGCGCCCGGTTCCGGGCCGGCTCCAATGCCGGAATGCTCGGCCTGGGCGGACTGCCCGGTCTGGGCGGACCGGCTGCCAGTGACGGGGATACGGAGGCGGGTGAGGGCAACAATCTGGACGTTCCCGCCGGCTGCAACATGGGTCGACGGCGCAGTCGAGCGGTTCTCTACCAGCTATCCGGGCACTACAAGCCGGAAAAGGGTGGCGTGAAGACCAAGTTGAAACTGGGCAAT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0011589:FBtr0086802:6
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.007 A=NA C2=0.224
Domain overlap (PFAM):
C1:
PF134261=PAS_9=PD(29.2=66.0)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0085981
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0309248
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)