DmeINT0026105 @ dm6
Intron Retention
Gene
FBgn0026376 | Rgl
Description
The gene Ral guanine nucleotide dissociation stimulator-like is referred to in FlyBase by the symbol DmelRgl (CG8865, FBgn0026376). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (3 unique). Gene sequence location is 3L:13906897..13925335. Its molecular function is described by: Ral guanyl-nucleotide exchange factor activity; Ras GTPase binding. It is involved in the biological process described with: regulation of Ras protein signal transduction; small GTPase mediated signal transduction; activation of GTPase activity. 31 alleles are reported. The phenotypes of these alleles manifest in: external compound sense organ; anatomical group; nervous system; somatic cell; mechanosensory system. The phenotypic classes of alleles include: visible; lethal; viable; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages.
Coordinates
chr3L:13913962-13919965:-
Coord C1 exon
chr3L:13919191-13919965
Coord A exon
chr3L:13914526-13919190
Coord C2 exon
chr3L:13913962-13914525
Length
4665 bp
Sequences
Splice sites
5' ss Seq
ATGGTAAAA
5' ss Score
4.79
3' ss Seq
CCAACAACTTAAATCTACAGAAT
3' ss Score
5.07
Exon sequences
Seq C1 exon
GGGCAGAGTTCGTCTTCGACTGTTGTTGGCGGCGGTTGCGTCGCGTGTCTCTCTACCGAGAGCTTTGTGTGTGTGTCTCGCGCGCGTTTTACGCTCTGCGCCCCCTACGCTCCCCTTTTCCAAGTAGAGAAACCCCCGAATGTGAATTTTGTATAATGTTTTTGTAATAACATGGATATCTCATGTTGAGATTTTCAGCCAAGCGAATGAAAATGCAAGCGGTATCCCGAAAATTGCCGTTTACGTGTGTGCGAGTGCAGCATTAGCAAAAGGAAAAGAGATAAAAGTGAAAACAAATAAATAGTAGGGAAGACGTGCTAAAGCACGAGAGCAAAGAGGAGATTGCCAGGCAGACGCATAGACGTAGTGCAACGAACCCTTCTTCGCGGACCAAGGATTCACCACTTACCACTAACCGGAGAACAAATACCAATATTAACCCCCCCACCTCTACTGCTACTGGGTGTGTTTCTCTATGTCCCGTTGACTCATCGTTCCCAGGAAGCTGAACAACGGTATAGCGGCCAGAACACAGAAGCCCAGTACAAAAAAAGAGCAGCAGGAATATCGATTTTACTTGCCTTTTACTTATACAACACCCCCACCACCCATTGAACTGCACTTGGGTGTAAAAATAAAACACCAGAAGCCATTAAAGGAGACGTGTAAATTAAAGCGAACCGACGAGAAGAGGATAACGGATAGGAAAACCCAAGCAGTGCATCCGTGGAAATCTCAGCAACATTTCTCAAGGAACAAAAGCCAATCTCAAATG
Seq A exon
GTAAAAAAAAACAACGCAATCCATCAGGCCGGATTAGAAAGGAGCGCACTTTAGATCTATTGGTTCTTATCCTGCCCTTACAGTGGTCACTCGAACGTTGATACATTGAAATGTTTTTTTTTAACAATATATTTAAAACAAGTACATCATATTTCTGCAATAAGCAATACATCGGTAACAAACTCCTGATAAGATAAAAACATTAATGGCTTGAATTTTATTACTATTGACCCTCGCCCTTAAATCAACGACATGGATAATTATCGATAATGCGCACCTTTTTTTGTCCGAGAATTTTCAACCCTGAAAACTAGTTGCTGTGTACTTGATCTGGTTTTGTGTGGAGAGGGATTACTGTAGTGTCTTGGTGTCGATTCACAAGGAAATGTCAACAATGATTATGGGCAAAAATGCAATGGTATGGAAACTTTACGCCTAAGTGGAGTCCAGAAATAAAACACCTTCTTTTGGTGGGGAAGGAATAGGAATCGATAAAAGTCGGGAATTTTTTACAAGTTATAAATGAATCATATGGGAACTGCCAAGCTTGGAGAAGCTTTGTTTTGGGAGTTTCGAGAATTTATATGCTAATTAAAAAGCATTCAAAATTGGTATACTTATGCTTGGGAACAAATGGTGTAGGGTATTCTTAAGTGATGTATATAATTTGTTTCGCAGGTGAAAGATAACGAATTAAAGCTATGAATTTAAAGGTGAATCAGTTTGAGATCATTTCAGTTGCAGTCCCAGTTATATTTTCGTTTCTTTATCATCCATTTATGCGGAGTGCCCCTAGAAATCATTTATCAGCTCCCATTGTATGCAAAACAAAAGCTCCGCCCCCCACTTCCTTTACCCACTGGCGAATGATGGGGGAATGCATAAAAAAAATAATTTACGTGGGGAGCTATGCTCAGTGGCTCAAACTTTAGCTTAGGTTGATATGTTTTTGTATTGTTTGCACATCATCTCTGCTGCTGCCCAACGGATGTGGTTTGATAATAGCCGAAAGAGCGGGACAGCTGCTCTGCAGTAGAGACAGATACATATGTACATATACACGTTAAATAAAAGTTTTATTCGGATATGAATTATGGTTTTTGAAATTAAAAATTGCAACAGGATGTGGCATCGGTTGATATTCGTTATGTTGTAATATAGCGAAAAGGAGACATTAGGGATAGAATATCGAATGCCAAGTAATGCCTGTTCTATTATTTCTCATAAACACAAACGATGTAAAATCTTGATGGACCTGTGTTAGTAGGCCGATGCAATTAAATTTGATCATAATTCCCTTCATTTTTTTTTATGTGCACCGAGGGAGCAGCAAATGTTGTCAAGTTGACTGCGTCGGATGCAGTCGCATGTAACTGACAGTCAGTCAGAGTCATTTAGCCAGTCAGTCATTTAGTCAGTCAGTCATTCAGGGATGACAGAGGGAAGGGGGAGAGACTGGTGTTTAGTTTCAGTCGTTTTTTTCCCTTGGCGTTTTCAATTTTGTTTTGCGTTGTTTTTTTTTTGCCGCTGCTTCTGTTGCTGCAATTCACAAAACTCGTGCCAGGGGTCGTCGATTTAAAAATAGAGATTTGTGTCTACAATTGCGGTCAAAATAAATGCCTTTTCATTTTTCAAGACAAGCGAAATGTATTGCTTATTTCGGACACCTAATCTATTGCCGCCAAGAACTAGGAAATTCTCAAAGAACTGTTTTTACATCGATACAAATTGCAATACTTTTACCTATAAATCGAATATCTCAAACGGAATACTATTTTACTATCTCAGAGTCATGTTTCATCATTTAAATATTGATCCATTTCCTTAGATGTATTTTCACTTTTAATCTATCAATATTGTGACCTCAGCTGTATGGCTGTTTGTTGATAAATTCACCCCAAATGCAAATGCAGTACCATTTCGCTTTGATGTTGCGGTTCGACTCTCCTTTGTTTTGGTTTCTGGCTATTTTTGCGAAGATCTGTAATTGAGAGAAACCCCCCCTGGGCGGAAAAGCAGAAAACGCCACCCACACGCTTTTCTGGAGGAAAGGTCACCTGCTTTATATATAGACAGATGATGATGTGGGCCGACCAATCAGGCGCCCCCTCATACTTGGATGTTATTTCTTTATAATTGGGTGCCTTGTATACACAAACACGAATATGTTTGACAATTGCCCGTCGTCTGGCATTATAATACTATATTATTTCATTACTTAATGAGCTTTATTTCTGCCGCAGTTTTTTTTGCACGGGCTGGGTATTTTCTGATGAATCATTCGAACTCAAAAGGTAAAATATCAACCGTATGCAAATCGTCATTTCCTCGCCGAGTTGTGTTCTGTTTCATTCGGTCTCGTTTGGCATTCGCTGTAATAATAATCGTGAATGAAATGAGTGTATTTAGGTTCTGGGGCTTGGTACGAATCGAATGCAATACATATATGTGCATATTGATTAGACGAAGGAATCTCAAACAAAAAGATTTCTATAAGTATGCGCATTGCGCATATTTACAAACATATATGAATATGTACATACATACATATATGGGTCTGGGTTGTTTGGCCTGGAGCTTTGAAGGATTTATTCTAATCAGTTTTCGGTTCAAAGTGTAACTTGGAGAAGCTTTCTTATATTTGCGAAATAAGCAAGCATATTTCTTATCGCCAGCAGCGCAGTGCTAACTAAATATTACATCATAAATAATATGCAATATTCTGGCTAATCATTACTAAGTTCTGTTCAAGCTTAATTGTTAAGCTGGGAAATTTCGAATTAGAAATTTTTCTATTGTTTGGAGTATTTAAGCAAATTAAATGAGGCATTTAAAATTAGTCTCACAATTGGTAGTTTTAGCTCAAACAGTATTTTAAATAAAAATTTTTTATTTCTTGATCTTATGATATATAATTGCTTTTTATAGTATAAATTTGCATATGACTATGGTTCATTGCACAAAACTAATTCGACCAATAAATTTGTATCCGTAACCCAGATGGGCATTATTCATGCTCGACTATGGAGCTTTAATTGGGGGTAAGAAAATCCTAGTCCTTCTCCACCGAATGACGCATGCCAGGCGAACGTGCCTCAATTATCGGTCGGTATTCGAATATATTTGGAGTATTTGATTGTGCTCGATTTAATTTTCGTGATGCGTATTTGATGGTTTGGTCTTCGATGCATTTATCGCTTATTTAATTTCAAGGCATCATATATGTATAATCTGGTTGCTCTTGGCCACGCGAGGCACGTTCCAGATTCGGGACCTCTGGAACCGACCTTTTTCCCCTTGCCTCACGCACGACCACTTCGCTGACCCCTCTGGAATAATTTGTTTTTGTCTTTTCGTTGTCAAGAGAGAGATGGCTTAAAGACCTACCGACCAAATGACATTTCTCTTCGCACGAATTTGGCCAGAAACGAGTTATGTAATTGGCAATGGAGCCGGTACGGGCTGTAATTGAGCAAAATTGCAAAATGGTCGGTGTTGGCCTAAATTTATGGCTAAGCTCTACATGAAATGGGCTGGGCCAGTTCATCTCTGGCGAGGTAAAAACCATAAAACCGATGGAGAAAAGGAAAGCGCAACGCAGTTTCCACACCACAGGCATGAAAATATTTATCTAGGCAAATATTGTGGAGCTTTCTTTGGAATTGAACGAAGCGGAAATGCTCTTCAAGAAAAGATAATAATTAAACAATCATTCTTATAAGCAAAAATATATAAAATGTATTGAAAATATTATTTTTTCTTTTTTTTATGAGCGAATATTCAAGTTTAGCCTATTATTTGAATGTAAATAAGATGCAGCTAATAATAATATTATTTGTTGTGGAAGAAGCACATTATTAAATATGATTAGAAGACTTTTGTGTTGAACTTGATTTTTAAAAATGCCTGTTTATTGTTCGAAACTTTTCCTGTTCCTTTCCTATCCATTGCTAGAGTATTTTCGGATGAATATATTTCCTTGGCGAAACCTGTGCGCAGCTGTCAATAGCCGTGAAATACTATGGCCCGAAAACAACGAAAACAAACTAGTTGGCTGTAATAACTTCCTGGTAAAAGTTGAACACATCCCGATTGGGAGGCCGGAATCGTCGTACTTGGGATGTTGTTTACGATTATAGGCCGGGATGAACAACGCGCCTAATATAATATGAAATGGTTAAACAAAGATTGCCTGTAAATCTGCCCCAGGGGATAGGGGATTCGCGGGGTAAAGACTTCCCATTAACCAAATATGGTGCGGATGAGTGAGTAGTGAGCGCCACTTGAAGTACAAAGTCGCTTGTCAAAGATACACTTTTCGTTTGTATGTTTGTTTGGTGTATTGTTTTTTTTTCTATTTTTGGGTATTTTTGTAGTTTTTTTTGTTTTTTTTTTTGGGTTGAGTAGCTCATAAACATCAAACAGCTGAACAATCCACTCGATTGTGGTCGTGTGTGCCTTTGGAGTCAAATCGTAGCCAAGGTCAGGGGCTCTGTGAACGAACTGAGAAGACAGCTCAAGTGGGTTGAGGGTTGCAGTCAATCAATGAACCACAGCCCGAGACCAAGATCAAGTACAAAGCAAACTCTTCAGAGTTTAACACCGCCCCCCAAAAATAATATTAAAAAATGAAATCCAACCAAACCCAACAACTTAAATCTACAG
Seq C2 exon
AATTTCACAAGTCGCGCCAACTGCAAATGCCCGCATAGCCAAAAGCACCAGCAGAAGCCCGCTCTGATCAAGAGTCACACCTGCGCCTATCAGCTGCAGGATCTGACAGGATATAATCGCGCCCTGATGCCTCCGCTGGATAACACGGACTTTAGCAATGCCTGGCGGCAGGTGAACAACAACACCACCAGCCAATCCTGCGCCTACCACCAGCAGCGGCAGCAGCAGCAGCAGCAGCAGGATGCAAAGGATTCCAAGAGGCACTATCACCATCACACCTGTCCAAGACAGCGGAAAAAGTCCATGACCCCGGTGGAGCCAACGCATTTGTGTCAAAAGCACCAGGAAGCCAAGCAGCGGCGATCTAGATCCGCATCTGCCAAGCCGCGCAGGAACAGTTCGTATCACTCCTATGACGACTTGGATGTCTCATCCGCGGTACTCAATGCGGAGCGAAAGGTGGTGGCCAGTTTAAAGTATCTATGCGCCTGCACGGGAGCCACTTTGAGGAATCTCTCCAAGAAAACCAAGGATCTGCATGCCAAAAACTATACCTACACGAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0026376:FBtr0075793:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.622
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0303219
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0075535
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)