DmeINT0031059 @ dm6
Intron Retention
Gene
FBgn0261397 | didum
Description
The gene dilute class unconventional myosin is referred to in FlyBase by the symbol Dmeldidum (CG2146, FBgn0261397). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 2R:7500147..7508625. Its molecular function is described by 8 unique terms, many of which group under: binding; protein binding; cytoskeletal protein binding; nucleoside-triphosphatase activity; catalytic activity. It is involved in the biological process described with 9 unique terms, many of which group under: organelle organization; establishment of protein localization; positive regulation of multicellular organismal process; cellular component organization or biogenesis; actin filament-based process. 24 alleles are reported. The phenotypes of these alleles manifest in: reproductive system; adult abdomen; male organism; plasma membrane bounded cell projection; peripheral nervous system. The phenotypic classes of alleles include: lethal - all die before end of embryonic stage; increased mortality; fertile; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes.
Coordinates
chr2R:7506655-7507377:+
Coord C1 exon
chr2R:7506655-7506786
Coord A exon
chr2R:7506787-7506848
Coord C2 exon
chr2R:7506849-7507377
Length
62 bp
Sequences
Splice sites
5' ss Seq
TACGTGAGT
5' ss Score
7.77
3' ss Seq
TCCATTTCCGCGACCTTTAGGCT
3' ss Score
6.26
Exon sequences
Seq C1 exon
ATACACCGATCTGACAAATGCCGACGATGATGTGCGCGAGTTGCTAAGCAAGTTCGTTATTCAGATTAAGAAAATGCATCGTACGCCGCATCCGATCGAGAATCGTGTTATTTGGCTCGTCAATTCCATTAC
Seq A exon
GTGAGTTACAAAGGTCATAAGCTCTTGGAATTCATAAATTAATCCATTTCCGCGACCTTTAG
Seq C2 exon
GCTGCTAAATCTTATGAAGCAATACGGCGACGTGGATGAGTACGTCAAGTTCAATACTGAGAAGCAGAATCAGCAGCAGCTGAAGAACTTCAATCTCTTTGAATACCGTCGCGTAATTCTTGATTTAATTGTGAACCTGTACCAGGCGCTGATCATGCAGATCCAGGGTCTGTTGGACCCAAAAATAGTGCCAGCGATTCTCAACAATGATGAGATTCAGCGTGGGCGGCAGGCGCACGGAATGCGTAGTCGGGCCACGTCGATTGGAGCATCCTCGTCACCGGAGCACGGTGGCGGTCCGGCCTGGAAGCAACTGATCGGGCAGCTGGAGCATTTCTACAAACAGTTTCAGCACTTCGGCTTGGACAACTGCTATGCGGAGCAGATATTCCATCAACTGCTTTACTTCATTTGCGCTGTGGCCCTTAATTGTCTGATGCTTAGGGGCGATATTTGCATGTGGGAGACTGGCATGATAATCCGCTACAATATCGGCTGCATTGAGGATTGGGTGCGCAGTAAAAAGATG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261397:FBtr0089745:14
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.045
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0184314=DIL=PU(46.2=27.1)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0088684

Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0088686
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AAAATGCATCGTACGCCGCAT
R:
GCTGCTGCTGATTCTGCTTCT
Band lengths:
142-204
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)