DmeINT0031615 @ dm6
Intron Retention
Gene
FBgn0000535 | eag
Description
The gene ether a go-go is referred to in FlyBase by the symbol Dmeleag (CG10952, FBgn0000535). It is a protein_coding_gene from Dmel. It has 8 annotated transcripts and 8 polypeptides (7 unique). Gene sequence location is X:14955477..15009989. Its molecular function is described by: voltage-gated cation channel activity; voltage-gated potassium channel activity; ion channel binding. It is involved in the biological process described with 11 unique terms, many of which group under: cognition; behavior; multicellular organismal process; learning or memory; transport. 31 alleles are reported. The phenotypes of these alleles manifest in: cytoplasm; organelle; nervous system; myofibril; cellular anatomical entity. The phenotypic classes of alleles include: mating defective; phenotype; sensory perception defective; behavior defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages, during early pupal stages.
Coordinates
chrX:14997934-15000110:+
Coord C1 exon
chrX:14997934-14998133
Coord A exon
chrX:14998134-14999857
Coord C2 exon
chrX:14999858-15000110
Length
1724 bp
Sequences
Splice sites
5' ss Seq
AAGGTAAGT
5' ss Score
11
3' ss Seq
AACTCGTTCACAATTCGCAGGTA
3' ss Score
6.01
Exon sequences
Seq C1 exon
CTCTGCTGTATGCCACGATCTTTGGTCACGTTACCACCATCATCCAGCAGATGACGTCGGCTACGGCCAAGTACCACGATATGCTGAACAATGTGCGCGAGTTCATGAAGCTGCACGAGGTGCCGAAGGCTCTTAGCGAACGAGTGATGGACTATGTCGTCTCCACCTGGGCCATGACCAAGGGTCTGGATACCGAGAAG
Seq A exon
GTAAGTTCCTGATACGACACTCCCATCGAAAAGAATCTTCCGGGAAGCGAAATTGCCTTAAGCCTTTTTTTCGTTGCCAAATCAGCTTATAGCTTCCAGAATCATTCATTTTGGCAATATGTCAGATGGAATAAGGATACATTTACTCACTTATGTGTCTCATTTACAAACGCTTTTAACGCTGTATAAAGTCAATGCGCTGGAACTGGGTTGCATTTGTACATAGCTGGCCTTTCCACAGAGCTTAGCATACTTCAGCCTATCACTATCTCTAATGCACTTGGCATACGCACACATACATGACATACATACATTAAAGAATTGTTCCTCTCAACTCGTTACTAGCCACTCGCCAATCGCCACTAAATTTTCCACATACAGCTGGTTCTTCTGCAAATTTTTGTTGGCCTTTTTGTTTAAATTATATCTTCTGCGTGTCTTTTATTTGTATATTTTATTTATGTAACGATCACTCCATAAGTGAATTTAGTCAGTTTATTATTTGGGTACTTTACCAATAAGTTTATATTATTTGGAAATAAATTTATTCATTGGTCAATCGTTTTGTCATTAGCAGCTTTACACAGACAATTTCACCATACACTTATTACTCGTACGTTAAACTACAGACACCACAATTATCGTTAATTGTTATTCGCTACCTCACCATGACACCTGTACTATCTCTCTCTCTCCAAAACTTTTTGACAAGAAACCTTTGGTCGCTGCTCTCGCGCTTTCTTTTTCTATTATTTTCAAGTTGCTACTCGCATTTCTTTAGGCCTAAGATCAAGCCCCATAAAGGCAAATAGCCCAATAGTCCAAGTCCACCCACAGAGCAAGGTCTGAGGTAAGCTGTGGGTGGCCTGAAAACTGAAAACTTATATCTGAAAAAGTGCGGAATCACCTTAATAGCTCTATACATCTAACGAAATCATCTTTAACAGAACTCAGCTAATCGATATATCTTTTCATTCTCTCCATGTGTCTGCCCGCGAGCGAGATCCGTGCCAAAACGAAAAGCGTCCGTCAAATTCATGCCTTTAGATGAACCTGAACCAAACGGCGCAGCGCCCCCTAGAAAGCTATAAACCTATTACCCTGATCACAGAAAAAAAAAACACAATTCAGGGGTCGTTTGCGCTTAAAATTTTGATAATATATAAAACCGAGTTTGGTTCACAGAGAGAAACATAGTTTACAACCGGTCTAAACCGTATAAACTGACCTTTATAACTATCTCGTTGACTGTAGTTTGTGCCGCAATTAAGATACCACCAAATCCCCGTCCTTGATACCCAAAATAAACTAGTGTTGTTACTTTTCCCTGAAAATTGGAAATAGCAATTAATATCACTCATAATACCACACACACACACAAACAGTCACAGACGCAAACACTAAAAAGGAAACAGGAAACACTCACACTGACACACTCGATCAATGTTGTATGTGTATTAGTGTATGTCTGCGTGTGTGTGCGTGTCCCGTTAGCCACTAGAGCTGAAGAATTCCACCCAGAGGATCAACAACTAATCTGGGTGGAAAACCTCCGTGGTGGTCCGCAATTTTTAAGTGTCCATACAGAAAGAGGTTTTTTAAATGAACCCTTTAAGTCGATAATCCAATTACACCAATCAATCTCGATCGCAATCGCTTCTATTCGATTAGTATCGAAACGAAGCCTATCGAACCGCCACTCGCAACTCGTTCACAATTCGCAG
Seq C2 exon
GTACTAAACTATTGTCCGAAAGATATGAAGGCTGACATATGTGTTCATCTAAATCGCAAAGTATTTAACGAGCATCCGGCATTTCGTCTGGCCTCGGATGGTTGTCTCCGGGCATTGGCGATGCACTTCATGATGTCGCACTCGGCGCCGGGGGATCTGCTCTATCACACCGGCGAGAGCATCGATAGCCTATGCTTCATCGTCACCGGCAGCCTAGAGGTGATACAGGACGACGAGGTTGTGGCAATATTGG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000535:FBtr0073955:14
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0052026=Ion_trans=PD(4.6=14.1),PF0129215=Ni_hydr_CYTB=PD(14.8=38.0)
A:
NA
C2:
PF0002724=cNMP_binding=PU(44.2=44.7)
Main Inclusion Isoform:
FBpp0301718
Main Skipping Isoform:
FBpp0073772
Other Inclusion Isoforms:
FBpp0292377, FBpp0301717
Other Skipping Isoforms:
FBpp0110308, FBpp0292378, FBpp0301719
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACAATGTGCGCGAGTTCATGA
R:
CCTCGTCGTCCTGTATCACCT
Band lengths:
351-2075
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)