DmeINT0032459 @ dm6
Intron Retention
Gene
FBgn0010303 | hep
Description
The gene hemipterous is referred to in FlyBase by the symbol Dmelhep (CG4353, FBgn0010303). It is a protein_coding_gene from Dmel. It has 8 annotated transcripts and 8 polypeptides (6 unique). Gene sequence location is X:13079205..13090434. Its molecular function is described by 6 unique terms, many of which group under: binding; transferase activity, transferring phosphorus-containing groups; kinase binding; transferase activity; protein binding. It is involved in the biological process described with 36 unique terms, many of which group under: cellular response to chemical stimulus; regulation of lamellipodium assembly; peptidoglycan recognition protein signaling pathway; cellular catabolic process; vascular endothelial growth factor receptor signaling pathway. 48 alleles are reported. The phenotypes of these alleles manifest in: chorionic specialization; adult labral segment; ventral furrow; embryonic/first instar larval cuticle; lamellocyte. The phenotypic classes of alleles include: viable; size defective; stress response defective; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, in adult female stages.
Coordinates
chrX:13082608-13085751:-
Coord C1 exon
chrX:13085596-13085751
Coord A exon
chrX:13083099-13085595
Coord C2 exon
chrX:13082608-13083098
Length
2497 bp
Sequences
Splice sites
5' ss Seq
GAGGTGAGC
5' ss Score
8.7
3' ss Seq
AATCAATCGTCAATTTGCAGGGC
3' ss Score
5.77
Exon sequences
Seq C1 exon
CCTCACAAAGAACCATCAGGATCGACCCAAGTATCCGGAGCTTTTGGCCCAGCCCTTCATCCGGATTTATGAATCAGCCAAAGTAGATGTGCCCAATTGGTTTCAGAGCATCAAGGATAACCGACTGCGCGCCAATGGCGATCCAACGCTCCAGAG
Seq A exon
GTGAGCCCATCCGGTGATCTGTGCCAGATCCTTCAGCATTATTCCCACGACCCGTCCGCTATTCCCGGCTGATGATGTGTTGTGCCTGTTGTGGATGTGTGTGAATAGTGGGTGTGTCTGAGATAGTGCGGAGCGCTTTGTATTTTCCCCACCTTTCCGTTTCCGTTTCCGTTTTCCATTTTCCGTTCTTTGTTCTTCGCTTAACGTGCTTCTCCAGTTCAACAGGTAGGAGAGGATTCAAGATGATAGCTGGGAAGCTGCAACTTTTGAATACCTAACCGTAGGATGGATTTCCTAAATTCATATTTTTGCTAGCCAACTAATTTAAACTGCTTGTTCCTCAACTTGTTTTATTTTCCTAATTTATATTTACTCTAGTTTTTTCAATCTCTTTAATTTTCTCTGGTGAGGCTAATTAACATTATAAACATACGCTTAGCTCCTCCGTTTCTTTCCTATCCCGTTTTGGCATGTTTAGCTTTTTTGTTTCATTTAATACACATTAAGAAAGCAAGTCCACTTATTAACTACATTTTTAGAAAATTAGCTAGCAATTAGATACGAGTTTGTTGTGCTAGAACAAATGCTCTTTCCACAGCTATTAAGTAGGTATATTACAAACTAAACAGGCTTAAAGATCATTGGAATTCAAATGTATAACTAAAAAAGTTGTACGCTAAATCTTTGAACCCCCTAAAATATACTCAAGATCAATCTACATTATAATGAGATTTTAATTAATTATTATTAAACTAGGTTATAGTTAAATTGATTGGGAATCTTTGGAAAGAGCATGTTGCCCCTAGTCCAATTGTAGTCTGGCTATCCACGCAACTATCTGTCTATCTTTACCCACTTAGATCCTGTATTTATTTGAGGACGAACCGAAAAGTGTATAATGAAATAATTATAAACATTTTGATGTACTTTCTCCTGTTTTGCGTTTAATTGACATTTTTATTTGAGTGTGTGTGTGCGACGTTTTTATTTTCCTTTTTCATCTTTTTTATTACCATTTTTTGTAGGTTACCTAATTCCTAATACCATTTCTTAAACAATAATGACAAACAATGAAGAAATCCAATAAACATAATCTAACAAAAAATAAAAGCAAACGAAAAAGAAGAAGACAAACTATAAACAAAAACCAAACATTAAAAACTATCGACATAAACTGAAAAACAAAACAAAAGCATTCAAGTAAACCTTGCAACCATCAACTCTATATACAGATATATAAACCTAAAAATATATTTACCTATATATAATGATAATGCCAACCAAACATAACTACTCAAAAAAAAAAAAAAAAAACGATAAAAACTCCTCCCAATTAAAAAAGTAAAATTCAGTAAGTACGACGAGTTTATTATTCTTATTATTAGCCTTCTAATTATGTTTTCATTAGTTAAGTGTAATCGTTAATTGTTGTAAACACGCCACATGCTCTGCTAACATTTATTGTGTTCATTATTTAATGATTCATCAATGGACTTTTGTTAATACTATGGTTTCGATTTACTTTCGCATGTTCTTTTCTGAATCTGGGCCTGGCTTTTGGCATCGCTTTCTTTATTTATTTAATTTATACTTTGTTTATTTACCCATCTAGAAATGCTCATACACCAGAAAAGGTAATTTGACACTGATTGTTTACTTAGTTTGCTTAATTGTATTACTTATCGGTTTTAAGATCATTACATTTGGCTATGCGTCCCTTTTCATTTATCATGCGTTTCCTTCACGAAAATGTGGGCTAGTTATTAAAATAACAATTAAATGGTTTTTTAATGTTGATAATTAAACGAATAGAATTGCTTGTAAATTTATGCTTAAGAAAACAAAAACATTATTAACTGAATCAAAGTAAAGTATATTTGAAATTTTGTAGTTTAGTTAGTTTGAGCATACAACCAATTGATCAGCTTTTGTTTTTTGGAACTTTCAATTTGGTTTGCAATTTGTGGAAAGGTGTTTTCTTAAACATTCTGCGATCTTTTTCTACAATTCACATTTGTTTTTTTTAGGAAAGTGTTATTTTGGAAAGCCATCATGAGCAAAGATTCTTTAATTCTGCGCGGCCATCTTTCGCTTTCGCTCCCTTTGGCATTTACCTGTGTTTCCCACCTGTCGCTTACACAAAAGAACACACAACTCACACGCAAAACTCACTCATCAACTTGTATATATACAAAACACACACATCGATCGATCACCAACACACATTCCAAATGCGATTACAGCTCATTTAAATGTCTTAGATATGTTGCCATTGCGCCGTCAATCTATTTAAATGTACCCTACAAACCCATCACATCCCGGATATCCTGATGCTTCCTCAAAATCCCCGATATATGTCCCCTAAATAGCCCGATGTATCCCCTCCAAACACAAACCTTCTTTCTGCCACTGGCGTACATTTGAGTGTGCTCTCATTACTGGTCATCTAGCCATTAAGAATGCACTAATCTTAAACGAATCAATCGTCAATTTGCAG
Seq C2 exon
GGCAACGGCGACTGGAAGTGCGATCGGTTCTGGGGCCGGATCTCTCGCAGGATCAGGATCAGGATCCGCAGGTGGAGCTGTAAAATATGGTAGGGCGACAACGTATGCGGGGCAGAGTCCCACAAATCCGCAGAAGACAATAAAACCCACTCAGATACCGAGTTACCAGCAGCAACAGTCGCAGTTTTTCATGCAATCAGCCACACAACTACCTCAAACAACAACCACAACACCGACGGCAACGACAAACTGTTTCGGCGGCAGCGGAAACGGAAATGGAAGAGGAAACGGCAGCGGCGGAAGCGGAAATGGTAGCGGAAGCAGCAGCAGTGCCAGTCCTCTATCGCCACCAAGCGCCGGTATCGGCGATCTTAACCGGCTTTATCGCAAATCGCCGTTCATGCAGCGAAAACTGAGCAACGGATCCCATCATCCGCACTACAAATATAACGACGAGAGCCCCAAGAAGGAGTCCATGTTTAGTAGCATCG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0010303:FBtr0073747:5
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.160 A=NA C2=0.908
Domain overlap (PFAM):
C1:
PF0006920=Pkinase=PD(7.7=37.7)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0073578
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0303422, FBpp0309264
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)