DmeINT0033890 @ dm6
Intron Retention
Gene
FBgn0004456 | mew
Description
The gene multiple edematous wings is referred to in FlyBase by the symbol Dmelmew (CG1771, FBgn0004456). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (6 unique). Gene sequence location is X:13214409..13258490. Its molecular function is described by: protein heterodimerization activity; extracellular matrix binding; cell adhesion molecule binding. It is involved in the biological process described with 20 unique terms, many of which group under: cell adhesion; biological adhesion; cellular process; cell-cell adhesion; sensory perception of chemical stimulus. 46 alleles are reported. The phenotypes of these alleles manifest in: visual system; mitotic domain; organelle; dorsal branch primordium; endocuticle. The phenotypic classes of alleles include: lethal; increased mortality during development; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period.
Coordinates
chrX:13220034-13225111:-
Coord C1 exon
chrX:13224984-13225111
Coord A exon
chrX:13220147-13224983
Coord C2 exon
chrX:13220034-13220146
Length
4837 bp
Sequences
Splice sites
5' ss Seq
GAAGTAAGT
5' ss Score
9.82
3' ss Seq
ATTCCCCGTTATTCGCTCAGACT
3' ss Score
5.18
Exon sequences
Seq C1 exon
TGTTTTAGTGGGAGCTCCATTGGATCAAAATCGACAGCCGAACACCACACACTCTGGCGCCCTCTGGCGGTGTCCAATGACACAGCGTTTCGATGACTGCGAACAAGTGATCACCGATGGCAGGCGAA
Seq A exon
GTAAGTGAATCATATCCGTGATGGTTAGCAACTAACTAGGATTTTTAGTAATTAAATTCGTAATATAAATACATATATGTTCAAATCTTAAGTCAATAGGTTCTTATGATAAGTATAAGTTAAATTAAGTCGATAACTGCTAACCCAATTTTGGTAACTGTATCCCTTTTATTTTCTACTTTATAAACCCGTATAAACATCCATTCATTGGTGCAGGTTGATTGGCTCGTGCCAGTCTTAAAAAAAAACATATATGTACCTATTATATAGATCTAGTCATAGTCGTAGATACCGAATCCCGCTCCCAATTGCCTAGTGACTAACCGGAGTGCCAATGGGTCAAGGATCATCCGGGCCTTTTAGCTAACCGATTCGCATTTTCAGTTTGCCCCAATATTTTTTTTATTTAAATCCCATTTAGTCTGCGAGTTGTACATAAACGATTGCCAAAAGCTGTATAGAGAGCTGTGACTAAACGTATCTAACATTTAAAACTCTTTTGTTAATAGTGTTAAGTAGGTGAGAACGCTGTGATCGATAAAAAAAAGGGGGTTCATTGCAAGCGATTGCAATTGATTCGACAAAAGAGTCATTGCATTGGAAATGAAATTGGGTTTGTCTCTAAGTCAATTGGTCTACCAAAAATATTGCGTGTGACTCGCCGCATTAAATATCATTTTATCGATCACATGTTGATCCGTTCGATTAACTTTGCAAGCGTATAGACCTTGAATCATTCGATCACATGATGACCACTCACTATTATTACTCGTATATATTCGTATTATCCACTAGTACCTACTGTATAGATATCGATTTTTGTTCTAGCATCTTATTCAAAATATATAAAACACAAATACTGATATCGATGAATACATTTAATTTAATTTTAATTGATTTGATCTTTTTTTCTCTTTTTTCTTTCTTATGTTTTTATTTTTTGTGCTCTCCCTTTTACCTATTTGGTTCCGTCAAAATCCAAATTCGTATTCGGTGCGCATAACTGGGATATTCATTTGTGTCTCTACCTCAACCCGAAATCCTAACCCGACCAACTCCAATTATCCAAAAAATACTGACAAATCTTTTCGATATTTGCCATTCGATAAATCGAACGAACGAATCCCTTAGCGAACGGAGCATATGAGATTAATAAGCGTAAGTGGTTTTGGGTGCTTTAATTGTTGTCTTGCCCACCAAAAACCGATCCCTAATACCACCCGATTCCCGATCAAGGATCGCGCATCTCATCGCAACCGCTAACACCAATTCAATATTCGATCGACCTATATACATATACACATATACGTATTACCAGTATGCCGTAATCAGTTATCATTCCTTTGGTTTGCGCTTTGATACGTTCACCTACTGATTTGAATTTAAATTTGAGTTGAATTAACCCCGGCATTTATCATACTTTCGATTCAGTGCACACATTTACTCCCAGCCCAAAAAGTAAATAAATTGCTAGTACACACATAATTATACATTTTGCCAATCTGGAATATGTGCGATCACCGAATGTACAGTCACGCACGTATGCCTATGGCCGCCATATTGCTTGCACCTCACTCTTACTTTAACTGTTACTTTAACTGACCTACCACGCATGCGCGCACTAATTGCAATCAGTTATTATGTACGTACGTATACATATAACATTGAAATGTATCTAAAACTACACATTGAGCTGTACAAATGTGCATTTTTGCTCACCTATTTAATTAAATGTCTATAACTATCTCACAAATATTAGAAATAAACACTCCGCACAAAAATCAATAAGGGTGTAATATTATTATCAATATGTTTTAATCAATTAGTTATCAATAAATCAGTAGTAAGACTTATGATATTTCATGGAAAACATTGAGAAATTTGCAATGGTGTCATTGAAAAAACATATGTTTGTTTTTGGTGACAATAGTCACATCTGTTTTCCAAATCCCTAGCAATTCCTTAACGAATTTAAATATAATCACCATAATTGCCCCTGTTATTCAGTTTAGCTATAAATATTTTTCAACAAATATACGAAGGCATTTCTGAATATTTTTGTTCGGAGCCATTTGCACGCTTCGATTGCAGCGACAACTTCATTATCGGCTTCACATGTTAAACATTTCCCCCCCAAGCATGCCCCAACTGATTCTCGGAATTTTTACCCAATACCATTGGCGAGAAATTGTGAAGTAGGGCCTATTTAAAAACCCCAAAGCCCCATATACGCGGCTTCACAATTTCGGCGACTTCAATTGGCGACTCATTTAGCGCTAATTATATAGTCATGGCAGCTGGGTTCTTAACTTTACACCCTCGTAAAGGGTGTCATATGATTTTCCAGAAATTCACATTGCAGTGACATAATATATGATATATATCTTTGTGCATATACAATTTCAAAAAAATAAAGCGTCTTAAAGCCTTTCCTTTGTCGGTTTTTTTTTTGTAATTGGTATTAAGCATTGATGTGCGGAATTAGTGTAAAATGCTTAAAAGAGTATTAAGTATTTGCATAGTTTTCACTCGTATGTATGTAGATCCATTTGCGCTTTTATACTGCTGTGTGCTTATGACCCCCTCTGCCAGTCGAGTGTTAACATGCAACTGGGTCGTCTGCATTTTTTTGAACGTCACTGTGACCGGGTTTCCACTGCCTCTTCTTCTTTCTCCTCTGGCTTCGCTCTTCTTCTTCGCTCTTTTGGCAATCAGAGCGTGGCAGTTTCAAAAGAAGAAGAAGAAACGTCTGAAAAATTCTAAAAACAAAAACAAAAACATACATACTAAAGCCAAAGATGTGGGCTTTGCCAACGGCGCCGCCCCAGAACGTGACAAATTTCTCAAACTAGGAGCACAGCAAAAAATACCAAAACGAAGTGCAGAACATTAGGCTACACAGAGAATAATTCTAGCAGAAGTTCACTAAACTATCTCCAATAGAACAACAATCAGAATCGTCACTTCATTTCAGAATTGCGTTACTATGCGTTGTATTTTAATATTTTTTCGCTGTGCACGCATGAGGGGCAAAAACAAATGTTGGCTGCGACATAAAAATAACCGCAAATTGCGAATTCTTAAGCGAAAATAGTGCGGAATTTTTGGCTTGCGAAATAGGGGGGCGGTCACTAAAATGCGGGGCTTTGGGTAAGGTTTTATTGCTGCATTGCTGCACATTAACCATAACCCCTTTTTTTCACCCATTACCTTCAGAAAACTGAATTCTTTTCGAGTTGGCCCAATGTCAGAAACGCAGAAAAGGGGCAAATTGAGGAGTGGAAAGGGGGAGTGGCACTGGGCGGCTCTTCCAGCTGCGCGACTTTCACTGCGCAAACGCGACAGACGGGCGCGTTTTTAAAACGCGTCAAACCCGTCAAGAACGGCCCACGCTCCAAGGCAAACCGAAAGAAGTTCGAAAAGAAACGCTACAGCGAAAGAAATTGGGTTGATTCAAACACATATGTATATTTCGAATCAACATTCTGTTGCACACTTACAAACAACGGTGAATGTTAAACCATACCACTACCAGTGTTAGACAACTAGAAAAACAGTTAGGGGATTTTGTTTCAGTGCACTGCAACTCCACTGTCTATCTCTCTTCCCCTCGCACGTGTAATAATCATTTATCATATTTCAACACTTTGATGCTTTAAAATGCATTCTAAATCAATTTCGTTCGGCTCTCTCTCTTTTTTTTTGCGGCTGCGCTTTCCATTTTGGTTTTGCCGCTCTTATGCTTCGTTTCATGCTTCGTTTAATCAACAACTTTTTGTTTACCTCTCCTTCCACTTTTTCTTTTTGTGCAACATGCCGCCAGCATTCAACAAAAACAAAAAAAAAAAAAAAAATAATCAAAAAACATGTTGCCCGAAAATCATCTGTAAATAATTCAATTGTTCCGAGTTTGAAGTCGCTTGGAATTTGCATTTTATCGCTTGTGTTTCAATTTAAATTTCGGGTTCAATATGATATCAGGGTGGACCAGCAAATACAACACAAAATTGGGTTTAACTTAAGTTACTGTAATTCCAATTGTACTGGAAACTTAAGGAGACTTCAGGTTTGCTTCAAAATAATCGATATTATCTAAATAACCATACATGCATACATATTTGTAGCCAACCAATTAGAAATTCATCAGCATTTATCAGCCTTTACGAAACGATTTTACGAAATGTATATTACATTAATTCCATCGTTTGAATAATTCTAGGAATATGTCATTAATAGCTCGGCTCATAATTTTGTAACATGGCTTCATTATTTAAAGGCTTGATTTTATATCTGTTATCTTAAAATAAATTAAAATTAGCCGGACTCTGATTTTATAAAATGTGTTACTTCTATCCGCGAGCGGTAAAAATACTATTTAATCGGGATTAAATGGTATACGTGGCGTATGAGTAATAAATCGATTTTTTACACTAAACCCAGTTTAGAACATTTGATCAGACTGGTAACACTTTTCCAACGAAGGTCCACCCTACTGTACAGATGTACATATGTACGTATGTAAAATTGTGAATGATTACTGTTGTTCCTACCATTTATAAATATGTATATAAACTGTTGATAATGCATACTACTTGTTGTTTTATAAAGTTATTAATTATTAGTTATAATTACCATTACAGTTGTTGTTGTTACTGTTATATTATTATTGTTGTTATTGCTGACATGCACACACACACACACACACACAAATGTACACAATCACAAACACGATCACACACATTAGATACATATCGTTTTTGGCAATTGTTAACATTGCAATTTCTCTCTGCACTCTCTCTTTCTCTCTCTCTCTGCGAATTCCCCGTTATTCGCTCAG
Seq C2 exon
ACTTCGACAGCGAAATCCTTTCACCGCCCGGCAATGACGAAATCAAGGAGGATCAATGGATGGGCGTTACGGTGCGTTCGAATCCCCTACAGGCCAACGGATCCGGCGGAAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004456:FBtr0073731:3
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.038 A=NA C2=0.487
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0309167
Other Inclusion Isoforms:
FBpp0302767, FBpp0302768
Other Skipping Isoforms:
FBpp0073562, FBpp0073563, FBpp0303424
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)