DmeINT0034440 @ dm6
Intron Retention
Gene
FBgn0015519 | nAChRalpha3
Description
The gene nicotinic Acetylcholine Receptor alpha3 is referred to in FlyBase by the symbol Dmel
AChRalpha3 (CG2302, FBgn0015519). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is X:8276200..8367169. Its molecular function is described by: acetylcholine-gated cation-selective channel activity; neurotransmitter receptor activity; acetylcholine receptor activity. It is involved in the biological process described with 6 unique terms, many of which group under: transport; localization; biological regulation; signaling; system process. 25 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: sleep defective; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
Coordinates
chrX:8287631-8292418:-
Coord C1 exon
chrX:8292250-8292418
Coord A exon
chrX:8287768-8292249
Coord C2 exon
chrX:8287631-8287767
Length
4482 bp
Sequences
Splice sites
5' ss Seq
AAGGTGAGT
5' ss Score
10.47
3' ss Seq
ATATACATATATTTTTGCAGGTC
3' ss Score
8.7
Exon sequences
Seq C1 exon
AAACGAGAAGTTCTACACGTGCTGCGATGAGCCATATCTGGACATCACCTTCAACATAACGATGCGTCGGAAGACTCTCTTCTATACCGTCAACCTGATCATTCCCTGCATGGGCATCAGTTTTCTCACCATCCTCGTATTCTACCTGCCATCGGATAGTGGCGAGAAG
Seq A exon
GTGAGTGCAGGGTATCAGTTAGTTGGGAGAAGAAGTATTTCAAGCTTGGTAAGCTTCAAGAGCTGGCTTCAAAAGTGTTTCCTTTGCATAACTATGCTCCTTCCAAGATATTTTTTTTTTGTGATTACACAAATGTTAATCGACTTAAAAAAAAGAAACTCCTAATAAATTAAAGCACATAATTCATTCGCCGAGATATAGTTATATTTATTGTACCCATGGTGGCAAAAAATAATTATATTTGATATTTATAGCCATCTTATTTATGGAGTTTATATGCTGTGCGGCTCGACTGATAAACGCGTTCAATTAATGAGCTAAAGTTTAATTAAATCAGTCGCAAAATAGTGGCGGGCCGAGTGTCTAAAAGCTTTATCATCTGCCAATTGGATTTATGCTAATGATACGCATGTTATTGCATTTATTCGCAGTGGAATTAACCATTAGAATCAAGTTCATTCGCAGCTGAAATGCATTAGCTTGAATATACAAAATTTTTCGTTGTTTTTTTTTTTATTTTCTTTTTTGTCCGCCCGATTTTTCCGCTGTATTTGCTTTGTTCACATCTGCTGCCATTTTCCCCGCGTTTTTCACCATTCTGACATTTTTTTTTTTTGCATTAAACCAATTGCCATAATTTATTGCCAGCTCAGACCACCAACACCACCCCCCGCCCCCGCCATGCCCCTCGCCCATCTGCTAAAAATGTGCTTTTAATTAAAAAGCAAAGAAAAAAAGAATAATAATAATTTCACACTCAAATGAAAATGAAAATGCATTTCAACATTTTATACGTTTTGATTTTAATTCTGTTTTATTTTTTTCGCCCGGCTTGCCATCATTTAAGTTTGAGTAAATAAAATTACACGATGTATTCAATTTAATGCGAACAAAAGTCTGGCGCGTCTATATAAACATATTTATGTATGTATATATATGTACACATATTTTCCTCTTTTTTTTTTTTTTTTTGTTGCGGTTCTTTGCGCGATTCTTTGAGGGGAAAAGCCAAACGAAAATGAAAACACGAAATGGCATAATGCATAAATATAAACATTTACATGCTGCTTGGGAGTTATGAATAAATTACGGCCAATTTTCAAAATAAATAAAATGCAAAAATAATTTGTGTGCGCAAGCGGTTTGTGGATTACTGATGCCGATGTTGATGCCGATGTTGATGTCGATTTCGATGTTGATGCCATCCGACATTTTCACATCGCTCACGGGGCATAATTTATGTTATAAATATTGACAGTGCCGGGCATTTGGCATTTTGCATTTGGCATTTGATGGGCCATCCCAGTAGAGCGGCAATCTTCAGCAGGCATTATGTAAATTTGCCGATTTGCGTGTGCATTATCGAGTTAAGAGCGGTGTGTTCACTGAGTGCTCATCAACACAAAACACGTATTTAAACGAAAGCGACATATTCGAGAAGTTCGAGGATGTAACTATGCATCAAATTCCACTCAAATAGCAATATTAGTAACTATTTTAGATTTCAATTGAGAAGTATTTAGGTAATAAGAAATGGCTTATTCTTATTGTAAATCAAACTCAATTGCATGCAATGCAATCAATATTTCGTTCGTGGCATTTAAAGTTGCCTGCTTCGATGCAAAAAATAATCAATTCGTGTGTTATTATTTTGCCAGGAGTTTGCCACGTTCAATTTTTTTTTTTGTATCTTTTACGATTTGTGCCATGTGGGCACATTTCATTGCACTGTTGTCCCTTTTATGGCCCGGCACGCACACTCATGCACTCACACTCACACACACACACGCACACACACACACATGGACAGACTGAAGCACTGACACACAGAGCTGGCAAATATTTGCGCCTAAAAGCAGGCAGCGAAATAAAACAGAACACAAACTGTGGAACAGTTCGCAGTTCGCTCGAAATGCCGAAACGCCACCGGTCAGTCAGTCTGCAGTTAACTGTGGCAACTCTGGCACGTCCGCCACGCCCACCGCCCCTACCCCCCTTGCAGTCGGTTTGGTCCTTTTGCAGCCCCGTGGCCGAAGTTCCATCGGAATTGGAATTGGAATTGCCAATTTACATGCATATGTGCCACAACGCACTTCATTCATGCAATTGCCGATTGCGAGAGTGTGCGGAAAGGCGGTGGTCAAAAATGCTTGCCAACACTGGCAAAAAAATTACGCCCAATAGAGATCAAATTACGGGGTTTTCCAATGTGGGGAGTTTCGCCATTTAAGACGTTACATTATTCGAATATACATATCTAAATAGAAAGCCACCAGCTTTAAACTAAAAGAAGTGTAAGTATTATAAATATTTTAAGCAAGTCATGCATTTTTTCAAGTGTGCTTAAAAACGACTGGCTACTTTTCCCGATACTAAGTAGCCGCACTGTTCCCAATTCGCCGACGTTTATTTGCATCGTATTTTTATGGCCGAAACAATTACGTTTTACGAACGGAGTCCAGATTGAAACTGGCCCATCATTTGGGGCCAACCGAACCATCCAGTTTGCATTGAACTCAACCCAATGGAACCCAAATCGCAAACCGAAATGCATTTGGCCACCTTAATTACACCGAGCATTTGCATAAATAATTAGCAATTCGTTAGTGATGGCAGCGTGAGGCGATTGCCCACGAATCGGGTTCATTGTAGCCAATCGTATCACCGCTAAGGCAATAGTTTAAATACACTTGAAAATATTATTTGAAAAGCAAATATATGTATATGGATTAAAAACATATACTATAAACCTGTTTTATATGTCGTAGTTCACTATTAAACCTTTTACATTTTCAAATCATAAATTGCATCTTATAATTATTGGGTAACTACGTGAGCATTTATCTCAGTGCATTTGTAGTTGAAAGATCGAGGATGTTGGCAATGGATTTGCTTGGCAAGTTGTAACCTTAATTAGGCAACGTCACTAATCGCTTTACAAGCCCTGGCCCCAAACTAAGGCTAATTATCATAAAATCATTAAGCATCGAAAATTTATGCTGCACACACAGACGCACAACCACCCACACACACACACACACACACCGAGAGAGAAACACACAGACAGACAGAAGAGAGGCTCAAATCGCCCGTCTCATTTTCGACATTTAATTACTTTATGCACACACACACACACACTCACAGCAAAAACCCATACACAAGCACACTTAATTACAATCAGCTTAGGCATAAGTAAGGTAAACTGCCACGCCCCCTCCGCTTCTTTCACACCCACAAATCATTTTTCGCTTTATTGAGCGCCCCAAAAAAAGTGTGCCGCGTTTTCGTTTTCATTTTGATTTCAGTATGAGGTTGGTTCGGGTTTTTCCCACCCCCTCGACTTATTCAAAAAAAAAATTTCTTTTTCGGCACTTTGCCGTTTTGGCCTTGCATATGATTTGTTGGCCAGCTTCTCTGGCAAGGCCGCAAAATGCCAACTGACAAACCGCCTTTTCATACGCCCATTGCCTCGGCTTATTATTTGCTTGTGATGCCCGCTTAGGCATTCTAAATCAATTTGGATTTGTGGCTCCAAATTGCCGCCCAAGCGAACGGAATCGGAATCTGAATTGGAATCGAAATCGGATTCGGATTGGTAATCGGCATCTTGGCAATTATATGGCATAGGAATTAAGACCACAACCTTGTTTCATTAGGCAGCAGGAAGATTGGTTAAAAAAAAAAAAGACAATCAAACGATTTATTTCCAAGAAAAATTGATTGAATTGTAGCTTCTAAATGAATTAAAATAATTTAGAAAATTAAATTACGTATATTAATACTACTTATCTATCAATTTATATAATCCAAGGCAGCTTATCGATTGCCTTCGTTAATTAACAGCGCCCAACTTTTGCTCATTAATTATTCCAAGCAGCTTAAATGTCCTGCCTATTATAACTATTTAAGCCAGCGGTCTTTCGTTACTATTTCATATAAATTAATTACAAGACACATAACGTCTTACGAAGGTGTTTCTATGTTAATAAACTAATCTTATTACTGAGTAATAAAATCTACTTCAGTTCCTTTGCTGAACTTTAATAATAGTACTAATCACTTATGATTCTCTTAACTAAATTCCCAGACACTTGATTTTCCACTAAGCGGTATTATATAATCGATATGTTTGCACCAATTTCGTCACTATTAAAGCACAGAGCAGCTAAAAAAAAAAATGTCGGAAAGTGACTGTAGGTTGGGAAAACGAGCTTAAGCTGCGTCTGAGCAATATTTTTATGCATTATAAATGAGATAGATACACCTTATCGTTCCGGGAGTTTCCCGTTGTTGTTCGCAGTTCGCAATTGTCGCTTCTTTATGGCGCTTTAGATTTTCCGCTCGACGTGCAGCTCAATTTGCCACGCCCCCAAAGCTCCCAAGCCGCCCACTTCCTGTCTCGCTCGCACCCACCAACATATTGTATATATGCACATACATATATGTACATTTTTATATACGAATATACATATATTTTTGCAG
Seq C2 exon
GTCTCATTAAGCATATCCATTCTGCTGTCGCTCACTGTGTTCTTCCTGCTGCTGGCGGAAATCATTCCGCCCACATCGCTGGTGGTGCCGCTGCTGGGAAAGTTTGTGCTCTTCACCATGATACTGGATACCTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0015519:FBtr0289988:7
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0293118=Neur_chan_LBD=PD(11.6=43.9),PF0293211=Neur_chan_memb=PU(6.0=42.1)
A:
NA
C2:
PF0293211=Neur_chan_memb=FE(11.3=100)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0288426
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0308714
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)