DmeINT0037624 @ dm6
Intron Retention
Gene
FBgn0019650 | toy
Description
The gene twin of eyeless is referred to in FlyBase by the symbol Dmel oy (CG11186, FBgn0019650). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 4:989725..1007922. Its molecular function is described by: RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with 8 unique terms, many of which group under: system development; anatomical structure development; multicellular organism development; tissue development; eye-antennal disc development. 35 alleles are reported. The phenotypes of these alleles manifest in: embryonic/larval brain; eye-antennal disc; head sensillum; presumptive embryonic/larval nervous system; presumptive embryonic/larval central nervous system. The phenotypic classes of alleles include: phenotype; lethal - all die before end of P-stage; increased mortality during development; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period.
Coordinates
chr4:998623-1004412:+
Coord C1 exon
chr4:998623-998705
Coord A exon
chr4:998706-1004157
Coord C2 exon
chr4:1004158-1004412
Length
5452 bp
Sequences
Splice sites
5' ss Seq
CAGGTTTGT
5' ss Score
7.44
3' ss Seq
TCGTGAAAAATTTTTAATAGGTT
3' ss Score
4.11
Exon sequences
Seq C1 exon
AATTTGAAAGAACACATTATCCCGATGTTTTTGCGCGAGAAAGGCTTGCTGATAAAATTGGTTTGCCAGAGGCACGTATTCAG
Seq A exon
GTTTGTCTTTCAGTTTTGTTTAATTATATTCAGTTTGTAGACCTTTTTTTGCAGAGCTCAATTTATTTATATTTTTGTAAATTATGTCAAACTAGCAATTAACTAATTTAAAATATTTTAATCGACCCTTAATGTTTTGGGCGGCACATACGAAAATGTATTTCATTTATTGTTGTAAACTATACTACTTAAACATACACACTTTCACGTTTTCTTCGTTTTAATATTTCTGGGTTTCATAACTAGAATTGCGCAAGCAGATTCAAATTGTAATATATGAAAAAATTATAATATTGCTACGCCCAGTTTAGCGCACATAAAGATTTTATATATAAATAAATTACCCTTCCCTGCTAATCCGGAACACATTAATTGTAAGCGTTATTCGTAGAGTAATAGGGTGTACTAGATTAGTTGAAAATAATGTTACAGGCAGTAGATGTAACGTCGAGATCTCGGAAACTATAAGAGCTAGAAAGTTGAGATTCAGCATACAAATTATAGACCCATGTTGCCACGTCCACTCTAACGCCCACAAACTGCACAAAACTGCACAAAACTGCCACGCCCAAATTTGGGAAAATTGTTGGATATTTTTTCAAATTTTTATGGGTCGTGTAAATTTCTATCGATTTGCCACGCCTACTCTAGGTCCCTAAAGCCGTCAAACCTGTACGCCCACACTTTTGAACAATGTTTAAATTGTTTCTCATTTTATTCCCCAATATCTATCGATATCCCAGAAAAATTACGAAATTTCGCGTTCGTATTTACACTAGCTAAGGAACTCGACTATAGCATTCTCTCTGGTTATACCCGTTACTCGTAGAGTAAGAGGGTATACTAGAAAGTACGTTTCCGACCATACAAAGTATATATAATTTATATCAGGATCAATGCCGAGTCGGTCTAGCCATGTCCGTCTGTCCGTATGGAGAGTGGACGAGTGACCACAACATCATTACTGTTGTGGCCGAACCAACTACCGCGCGCGCAGTTGAGAGCATAGCTCCTGTGCCGTCCTGGAACTTCTCCAATGCACGGTGGCAATTGTTCAAGGAGGAAATGGTGAGTAGAGCAGCCGAGCTCCCGGAAAACTTCTCAGAGTCGTCGTTGGACCAGCAAGTTTCGACCCTGCGCAGTACAGTACATAATGTATGTGATATTGCGATGGAAAGAAAGTTGACTCAATCGCCCAGCAGGAGAGCTCGTTGGTGGTCCGGAGACTTCGTCGCCTACTCCAAGACGGAAGGCGTCGTGATGACGATGCCGCTGTACTGCTTGTAGCTCAGGCGTGCCTCAGCCAATTGGCTGATTGGGAGGGTGAAAATGGATGACTGGAAACGCTTCGTGGGAGATCATGCCGACGACCCATGGGGGCGCGTCTACAAGATTTGCCGAGGCCGCAGAAAGTGCACGGAGATTGGATGCCTCCACGTGAATGGCGAGCTGATCACTGATTGGGGTGACTGTGCACGAGTGCTCCTCCGCAATTTCTTCCCAGTCCCTTCCCTTCCCAGTCGGAGTCCGAAGCACCGACTGCCATCGCGGAGGAAGTCCCACCGGCCCTCGAAGTATTCGAGGTTGATTTATGTGTTGCCCGGTTGAAGAGCATGCGCTCTCCCGGCTTGGACGGCATCAATGGCACTATCTGCAAGGCAGTCTGGCGCGCCATACCTGAGCACCTAGCATCGATGTTTTCCCTATGCATCCGATTGGGAGCTGAAACGTGGATTCCCGCTGGAGGAGAACGACTGGCTTCACGGCGAAGACATTGCGTGTCTAAGCTGGGAGCAGAGGAAGACACGCCTAGAGGAGTGTTTATTCCAGAGTTGGCAGAACAGATGGGACGACGAAAGCGAACCAGGACGGGTGACGCATAGGTTTATGCCATCCGTCACTCTCGCCTATCGGGATCCAAGTTTTGGATTCTCGATGAGGACGTCTTTCCTGCTTTCAGGCCACGGGTCGTTCAGTGCAGCGATACCACTGCTTGCGCATGTGGAGGTCCATATGAGGACTGGATGCACATATTGTGCGCTTGCCCCCTATATGCAGATTTGCGGGACCTTGATGGACTTGGAGTGCAGCGCCTTGGCGAAAACACGCCACAAGTTCGGAGGGATCCGAAAGTCATACATATATGAACGTTGAGATCTCAGAAACTATTAAAGCTTGAAGGTTGATATTCAGCATACAGAATACGCAGTGCAAGTTTGTTGCCACGCGCACTCTAACGCAACAAACCGAACAAATCTGTCACGCCCACACTTTTAAAAAATGTGTTGATATTCTTTGCCGCGCACACTCGACGCCCTAAAACCGGCCAAAACTGTAACGCCCACATTTTAAACCATGTTTCGATGTTTGTTCATAATTTTATTAGTCTTGTAAATTTCTACCGAATTGCCAAACAACTTTTTGCCGCGCCCACTTTAACGTCCTCAAGCCGCCCAAAACTACCACGCCCACATTTTTGAAAAATTGGTAGATATATTTTTATAATTTTATTAGTCGTCACAATTTCTGTCGACTTGCCAAACAACTTTTTGCCACGCCCACACTAACGCCCTAAAGCCGCCGAACCGATCACGCCCACAATTTGGAACAACTTTTAAGTTTTTTCTCATTTTATTCCCCAATAAATTTCCCGTTCGCATTCACACCATCTGAGTAACGGGCATCGATAGTCCGGGAACTCGACTATAGCATTCTCTCTTGTTTACCTAATATTTTCATATCATCCTCGCACTACGTTTTGCTGAGTAACCGCTATTCGGCCGATTCTAAGCTAGCTAGTCTGCATAATAATTTCCCAAGTTTCGTTACATTACAGGTAGATTATATGTATTTCGGAACGACCGACCCATTATATAACAAAACTGCCTAAAAAACTGAAAAATTAAAAAAAAAAACGGTACCCTTGTTTTTTTTGTTATACTCGGTATAATCCAAATGTTATAGAAAAATATAGAAAATATATTCTTCAAGGCTATATAAGCTCAGCTTGCCGAAGCTTTAGCTTCCTTTCTTAATATACCCCTTACTAGTATGGTACTAGATTAATTGAAATGTATTTAACAGGTACAAAAATGCGACTCCAACCATGGATGTATATATATACATTTACATTAAATTATTTCTTCAGCCTAATTTTAACTTCCTAACTCTTAAGGCTCCCGAAATCACTGCATTCTTACAGACGTAAAGATGAAATGGCACAAATACAGACGGACATGACCAGATCGACTCGGCTAATAATCCCGTATATGAATACACATATATGTGTACTTTAAAATCAACTTATCAGTATTTTCGCAACACATGCATAAGAGTATAATAAAATAACTTACCTCTGTGCGTTATTTTAATAACTGTATCTTGCAAAATAATTGTAAAACATTTTAACTCGAGGCGTCAAGTATAAGCAGCGGAATGGGCGGTTTAGAAGTCATCCCTCAACTGCTTTTCACCCCTAAAGCTGTGTTGTTTTGTCGTCAAAGTGAGATGAAATATTTATCGTTCCGCTCTTGATTATTTGTTTAAGTGAATAAAAACAATTTGACTGTAAAAATACTTGATGCTTCTTGTGATTTTTCGCATTGAGTGGTAATAACGGGGGCGAAGCTTGGATTTACCAAGCTTGAAGGGCTTGGTCGGAAGCCGGAGAGGGAGCTGCAACAATAACGCTGGGTAATAAATGTCATGGGGAAAATATATTAAAGCAAAAAGTATTGTAATACGTTTTCACCCCTTTGTCATCTTGAATGCTTTGGCTCACTTTATTTCGCTTGTGTTATGTTACAAGTAAAACCGCATATAAAGCGTGTATTTCTCCTAACCTAAACTGCGTGACAAAAGAAATATGAAAGTTCATTAGACTGCAAGTTTTTTTTTTCAAAAAAAAAAAACATTGTTATGCTCTTTCCACTTTAGTCATAATAAAAACCAATTCCAACAGCATAATAATCCCGTTCCTTACCTTAGTCTACGTACATGTGGCTGTGGGTGCCACTACTAAAATTTATTTTTTGTAATCAGTAAATGCAACCAAATCGTATTCTGAAAATATTTAAACACCCATTTTAAAGTTTTTTAACATAAAAGTAGCCAACTGCTATTTTCCGCTAAACTCTTCACAATCTACATAATAAAGAGCCCTAAATCAGAGGTTTCATTGATTCAGCGGAACTGACAAAATGACACACAAGTTACGTGTTTACCTACGAACAACAACAAAATATTTGGTACACGAAATTCATTCATTAAAAACAAAGAAACAAAGAGAATGCTATAGTCGAGTTCCCCGACTATCAGGTACTATCAGGAAGATGGGCGAAGGGCGAAATTCTATAATTTTCTGGCATACCGATAGATATTGGCAAATAAGATGAGAATAAATTTAAAAAAAAATGTTAAAAAAAACATAGGATAAAGGGCACAGTATTTTTGGTATACCGATAAAAATTGGCAGGACAAACAACAAAACAAAGGAAAATCAAAACATTTGAGCGTTTGGCAAATCAAACAAAATTTAAAAGACTAATAAAAAAGTGAAAAAATTTTAACACATTTTTTAAAGTATGGGCGTGGCAGTTTTTATCGCTTTGTGGGTGTTAGAGTGGGCGTGGCAACATAAGTAAACAAAATTGCGTCTTTGTCTCTGGAATCTGTATGCTTAATCTCAACCTTTAAGCTTTTGCAGTTCCTGAGATCTAGACGCTATTGATGCTGATCAAAAAAATATATATTTTATATGGTCGAAAACGTTTTCTTCTGCCTGTTACATAGATTTAAACGAATCTAGTATACGCTTTTAGTCTACGAATAACTTAATTTGTTTGCGACTTGTGTTACGTAAGAAGCGGTGTGGTCAAACTTTTGATAACTTTAGAAGACTAATATAAAAAATATTAAATAATTTTACAAAGTGCAAAATTTGGGGAAAAAAACTTTTGCTGCGTCTATGTCTCTGGAATCTGCACTCGTTTCAACTTATTATCTTTTATAGTTTCTAAAATCTTGACGGACAGGCGGACGTACATGGCCAGATTGACTCGGCTTTTGATCCTGATCAACAAAATAGATAGATGTATATATTGTAGGGTCGGAAACGCTACCTTCTACCTGTAACATACTTCTTAACGAACCTGGTAACGGCTATAAAAAACTTCTTAGTAAATACATACTAAATTTGAAGTAATTTTAAGAAGCTTCTGATAAGCTGATTATTATAAGTGCTTAAAAAAAAGTCGATTTAGCGGATTTCTATGGCAGTCTAGTAACTAAAAATTTGTAGCTACATACATTATTTAGCTTAATTATTTTCTTTTTTTTTAGTTTAAATAGTTAATTAACTATATTATATTATTAAAATATATTTTTTTCAGAAATATTAAGTTCGTTTAATATATAAAAATCAATAACCTTCATCGTGAAAAATTTTTAATAG
Seq C2 exon
GTTTGGTTTTCAAACCGACGAGCTAAATGGCGCCGAGAAGAAAAAATGCGAACTCAGAGACGATCGGCCGATACCGTGGACGGCAGTGGTCGAACCAGCACGGCAAATAATCCTTCAGGAACAACTGCATCTTCCTCCGTCGCAACGTCAAACAACTCGACTCCAGGGATTGTGAACTCAGCAATCAACGTTGCGGAACGAACATCATCTGCATTAGTTAGTAATAGCCTTCCCGAGGCTTCAAATGGACCAACT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0019650:FBtr0089185:5
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (disopred):
C1=0.704 A=NA C2=0.859
Domain overlap (PFAM):
C1:
PF0004624=Homeobox=FE(47.4=100)
A:
NA
C2:
PF0004624=Homeobox=PD(19.3=12.9)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0088249
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0308592
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)