Special

FBgn0019650 @ dm6

Biotype
protein_coding
Gene Symbol
toy
Description
The gene twin of eyeless is referred to in FlyBase by the symbol Dmel oy (CG11186, FBgn0019650). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 4:989725..1007922. Its molecular function is described by: RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with 8 unique terms, many of which group under: system development; anatomical structure development; multicellular organism development; tissue development; eye-antennal disc development. 35 alleles are reported. The phenotypes of these alleles manifest in: embryonic/larval brain; eye-antennal disc; head sensillum; presumptive embryonic/larval nervous system; presumptive embryonic/larval central nervous system. The phenotypic classes of alleles include: phenotype; lethal - all die before end of P-stage; increased mortality during development; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period.
Coordinates
chr4:989725-1007922:+
Assembly

GENOMIC BROWSER[edit]


EXPRESSION VALUES[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Alternative 5'ss
0
NA
+
29.24
69.59
0
Alternative 5'ss
12
chr4:998694-998705
+
70.76
69.59
0
Exon Skipping
44
chr4:991044-991087
+
0.5
10.96
0
Intron Retention
1563
chr4:990503-992065
+
16.96
83.81
0
Intron Retention
4265
chr4:992247-996511
+
8.26
58.51
0
Intron Retention
957
chr4:996750-997706
+
7.63
59.3
0
Intron Retention
5452
chr4:998706-1004157
+
10.62
44.9
0



Orthologous genes[edit]

Organism Assembly Gene ID Gene Name Orthology Type

Human hg38 ENSG00000007372 PAX6 2-to-1
Human hg19 ENSG00000007372 PAX6 2-to-1
Mouse mm10 ENSMUSG00000027168 Pax6 2-to-1
Mouse mm9 ENSMUSG00000027168 Pax6 2-to-1
Rat rn6 ENSRNOG00000004410 Pax6 2-to-1
Cow bosTau6 ENSBTAG00000004561 PAX6 2-to-1
Chicken galGal4 ENSGALG00000012123 Pax-6 2-to-1
Chicken galGal3 ENSGALG00000012123 PAX6_CHICK 2-to-1
Zebrafish danRer10 ENSDARG00000045936 pax6b 2-to-2
Zebrafish danRer10 ENSDARG00000103379 pax6a 2-to-2