HsaEX1023358 @ hg38
Exon Skipping
Gene
ENSG00000162591 | MEGF6
Description
multiple EGF like domains 6 [Source:HGNC Symbol;Acc:HGNC:3232]
Coordinates
chr1:3524124-3579929:-
Coord C1 exon
chr1:3579825-3579929
Coord A exon
chr1:3524385-3525082
Coord C2 exon
chr1:3524124-3524246
Length
698 bp
Sequences
Splice sites
3' ss Seq
CAGCTGCATTGGTTTCCCAGGGC
3' ss Score
5.55
5' ss Seq
GATGTGGGT
5' ss Score
2.02
Exon sequences
Seq C1 exon
CTGAATGCAGCGCCAGCCTCTGTTTTCACGGTGGCCGTTGTGTGCCAGGCTCAGCCCAGCCGTGTCACTGTCCCCCCGGCTTCCAGGGACCCCGCTGTCAGTATG
Seq A exon
GGCTGCTGGAACAAACACCGCAAACGGGGTGGCTACAAACTATAGAAGTTTCTTCTGTCGCCATCTGGAGGCCAGGATTCTGAACCCAAGGTGTCCGCGGGGCCACGCTCCCTATGAACCCATAGAGAGGACCTTCCTGGCCTCTTCCTTCTGGCCGTCCTTAGCCCGTAGCCTCGTCACCACAATCTGCCTGGTCTCCACATGGCCCTCTCTGTGTGTCTCTTGTTGGGATAGGCGCATTGGATTTAGGGCTCACCCTCATCCGGAACAATCTCATCTCGAGCCTGAACTTAGGACAGCTGCCAAGACCCTGTTTCCAGACAAGGCCTCACTGGAAGGCTCCAGATGGCCATGAACTGCGGGGACACTCTTGAAGCCAGCACGCCCTCCCCTTTCTCAGGCTTCCCCCCACAGCCTGGGCATGGCCGTCTCAAAAGCTGTCAGTTTCTCTTTTTGGGCTTGTGGGTCCTGGTGGAGCGGTTGACACCGCCCAGGAAGCACTTTGTAGATTTGGACTTAAGAAAACCGCGTGCGCTCCCGGTTCAGTCTTGAAAGGCGCTAGAGGCCCAGCCTGTCCTTGGAGCCCTCTGCTACTCCCCACCTTCTGGCCGGCCCTCGAGGCGGTGGCTCTTCCTTCTCGAGCAGGTGTCCAAGGTGGAAGCACAGACCCTGTCTCTTCTGCTGCGTCTCCGGCAGAT
Seq C2 exon
ATGTGGACGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTGAGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCCTGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000162591_MULTIEX2-1/15=C1-2
Average complexity
C1*
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.045 A=0.000 C2=0.062
Domain overlap (PFAM):
C1:
PF079748=EGF_2=WD(100=86.1)
A:
NO
C2:
PF146701=FXa_inhibition=WD(100=85.7)
Main Inclusion Isoform:
ENST00000356575fB19782
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTGAATGCAGCGCCAGCC
R:
CAGGTCCTGCTGTCAGTGTG
Band lengths:
223-921
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains