HsaINT0000025 @ hg38
Intron Retention
Gene
ENSG00000175899 | A2M
Description
alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7]
Coordinates
chr12:9104239-9106345:-
Coord C1 exon
chr12:9106236-9106345
Coord A exon
chr12:9104401-9106235
Coord C2 exon
chr12:9104239-9104400
Length
1835 bp
Sequences
Splice sites
5' ss Seq
CAGGTGGAG
5' ss Score
2.57
3' ss Seq
CCACAGCTTTTAATCTTCAGGTG
3' ss Score
6.84
Exon sequences
Seq C1 exon
TGGTGGAATTGACTGGAAGGCAGTCCAGTGAAATCACAAGAACCATAACCAAACTCTCATTTGTGAAAGTGGACTCACACTTTCGACAGGGAATTCCCTTCTTTGGGCAG
Seq A exon
GTGGAGTATTTTCCAGTTCACTCATCAACCCATGTACTGTTACCTAATTAGCACAATAGTTATGGTTTGTGCTAAAACCATGCCTGGTTAATGTTATCATTTAATATAACCAAAAGTATAAAATATCACCAAGGCTTGATTAGTATAACCAAAGGTATAAAACTACATAAAAATAGATTTATTCTTCTGTAAATTTGTGTATGAAATGTATGTAATTATCCTAAGGCCTTATTAAAATTAGTAGAGTTTTCCCCCCTTCTTTTGAAACAGCATTGTACAAGTCACTCAATCTCCTTCTCATGGTTTACCAGGCAGTCTCAGGTTTTTATGACATTTTCTCACAAGAATCTCAAAATTCATGCTGACCAGTTTCATTACGATGCTAACACTAACTTTGTATGGAAACAGGTGGGTAGGTGGTTTTAATTTTTATTTTGAAGTATTAAAGATTCTACAATAATGTTTATTTCATGGATAGTATATTTACACTATTTTTCTATAACAAGTATATTTCTAAAACAGTGAACATGGGGTAAAACACTGCTATTTAAGGTTCTCAGATTTTTGAATTATGAATTTTCATGTTATCTACCAAAAAAATCTTCTCTTACAATTTTTCTGTTGTCAGCAGATGTGCAAATGGATCTTTATGACTCTAGAAGTCTGAGATCACAGTTACATGTGCCTCAATGTGTATTTACTGTGTATCATTTTCTTAATGTAAATGTTACAGGATTTCAGCTATGAAGGGTGTAAAAGAGGCATAGACTCAACAAAGTGGAGTACATTCTAGAAGGCTTGGTTATGTCATGACACCAAAATGTATTCAACTTCCTAAAATGAAAGTGTAGCTCATTTGTAAATTTCTCAGAAAGATAGTGTACTTTGTAAGTACATTTTATTGCTGTTAAATATCCTATTTGTCATAAGACTCTCTAGCTAGAAGAAAATCAGAATTATGTGCCTATTCTTGTCTTTGTACATGCAGCCAACATTTCACTGGCAAACTTAGATTTTGTAAATCAATTATGAGTACTGATGGGGGTCAGCCTATTGTTCTTCCTGCTACCAACTGTAGCTTATACTGAAAAAGAATTGCCACCTTTACAATCTGAACTGGACTACTCAACTGCCAATACAATATTAGCAGTAAATTAGATTTGGCAACTTATTTAATACTGTGTGCCTCTTTTCAATTTTATATTTTTCACATGGGAAGTGTGTCATAAAATCTGCCTACCTTCCAAAAGGCTGAAGATCTAGGTTGAGAAGCAGAGACCATGTCTAAGGCAACTGGAGAAACACACAGGACAATGTATTGGCAATTGTTTACTTGTGCACTTATGAGACTTCAGACACTAATCTATAGGAAGTTAATGGTCCACTCCAAAATAGGTGTTTGGGGCACAAATAAATTTAGTTAATAGATTAATAGATTAAAATATTTCATTATCATATTACTCTAGTGCTCTGTGACTCTCTAAGAGTTATATATAATAATACACAGCACTTCCAAAATATCTAGAAGACATTTTTCAGGTCACTCTTGTTATTATCCCTATCACTCTCTATCCCTTCACACTGCTCTGTTTTTCTTCTTAGGATTGATTACTACTAAATTAGTGTATGTTATGTATATATTTATTTAGCATCTATCTCTTTCACTAGACAGTAAGCTCTGTGATGGAAGAAACTTCGTTTTTTTTCACTGCTGTGTCCTCAGTGCCTGGAACCATGTTCAACATAGAGGAGGCACTAAAAAATGTGATAAATGAATATGTTTGGTGCCTATTAGTTATTACCAATATAACTAATCCACAGCTTTTAATCTTCAG
Seq C2 exon
GTGCGCCTAGTAGATGGGAAAGGCGTCCCTATACCAAATAAAGTCATATTCATCAGAGGAAATGAAGCAAACTATTACTCCAATGCTACCACGGATGAGCATGGCCTTGTACAGTTCTCTATCAACACCACCAATGTTATGGGTACCTCTCTTACTGTTAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000175899:ENST00000318602:10
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.027 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGTGGAATTGACTGGAAGGCA
R:
CCTAACAGTAAGAGAGGTACCCA
Band lengths:
271-2106
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development