HsaINT0000090 @ hg19
Intron Retention
Gene
ENSG00000166535 | A2ML1
Description
alpha-2-macroglobulin-like 1 [Source:HGNC Symbol;Acc:23336]
Coordinates
chr12:8988851-8990162:+
Coord C1 exon
chr12:8988851-8988935
Coord A exon
chr12:8988936-8990035
Coord C2 exon
chr12:8990036-8990162
Length
1100 bp
Sequences
Splice sites
5' ss Seq
TAGGTAAGA
5' ss Score
9.14
3' ss Seq
CTTATGCTTTTCTTGGTTAGGTA
3' ss Score
7.82
Exon sequences
Seq C1 exon
TGCTGCCGAAGTTTAAGGTGGAAGTGGTGGAACCCAAGGAGTTATCAACGGTGCAGGAATCTTTCTTAGTAAAAATTTGTTGTAG
Seq A exon
GTAAGAGCAGAAGCTTGGGATCTGGTGGAGATTAAAGATGCATCGAGAGACATGATGAGGGGATGACATGGGATGTGGGATTATGGGTGGGCCAAAACTTGGGGCATTTTATGTAATTCAGAGTCATGGCTTATCCAAGACCTTTTTTTTTTTTTTTTTTTGAGACAAAGTCTCACTCTTGTTTCCCAGGCTGGAGTGCAATCACGTGATCTCGGCTCACTGCAACCTCCGCCTCATGGGTTCAAGCGATTCTCCTGCCTCAACCTCTAGAGTAGCTGGGATCACAGGCGCGCGCCACCATGCCTGGCTAATGTTTGTATTTTTAGTAGAGATGGGATTTCGCCGTGTTGGCCAGGCTGGTCTCGGACTCCTGACCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGTTGGATTACAGACGTGAGCCACCGCGCCCAGCCAAGAACATATTTTATAGTTGTGTTTCTGCTGTTTTTTTCCATTGCTCACTCAGATAGTATTATTGATTTAGTCTTTACAAGACACAATATTGAATCCCATAGATAAATATGGATCAGGAGAAAGAAAGATACTGTTTCCGTCCTTAGTATGGTGCTAATTGTGGAAGTGGGTCTACTCTAAGACTCTGAGTAAAGTAGGGAAGGGGAAGAGAGCTAGAGAAAGGTAGGATTGTCAGAGCTTGCTTTCTTCTTTTTTTTGAGACAGAGTCTCTGTCACGCAGGCTGGGGTGCAGTGGGGAGATCTCAGCTCACTGCAACCTCTGTCTCCCAGGTTCAAGCGATTCTCCTGCCTCTTCCTCCCGGAGAAGCTGGGATTACAGGTGTGAGCCACCATGCCCAGCAAATTTTTGTATTTTTAGTAGAGACAGGATCTTGCCATGTTGCCTAGGCTGGTCTTGAACCCCTGGCCTCAAGTAATACACCTGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACTGGCCCAGATTGTCAGAGCTTTCTTTCAGAGGCTGGAGTGTGAGAGGGAAGAAGTGGTGTTTGAGGGAAGAGTTGGATCTCAAGTGGAATTTCCCAACTCTGACTCCTTATGCTTTTCTTGGTTAG
Seq C2 exon
GTACACCTATGGAAAGCCCATGCTAGGGGCAGTGCAGGTATCTGTGTGTCAGAAGGCAAATACTTACTGGTATCGAGAGGTGGAACGGGAACAGCTTCCTGACAAATGCAGGAACCTCTCTGGACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000166535-A2ML1:NM_144670:7
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.070
Domain overlap (PFAM):
C1:
PF0183514=A2M_N=PD(19.5=79.3)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Rat
(rn6)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCTGCCGAAGTTTAAGGTGGA
R:
TGTCCAGAGAGGTTCCTGCAT
Band lengths:
210-1310
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)