HsaINT0013363 @ hg19
Intron Retention
Gene
ENSG00000126522 | ASL
Description
argininosuccinate lyase [Source:HGNC Symbol;Acc:746]
Coordinates
chr7:65541026-65546984:+
Coord C1 exon
chr7:65541026-65541080
Coord A exon
chr7:65541081-65546789
Coord C2 exon
chr7:65546790-65546984
Length
5709 bp
Sequences
Splice sites
5' ss Seq
GAGGTGAGT
5' ss Score
10.03
3' ss Seq
GTTCTTGCTCTCCTGGCCAGAGT
3' ss Score
5.57
Exon sequences
Seq C1 exon
ACCCGGAGGACCGAAGCTTCCGGACGACGAGGAACCGCCCAACATGGCCTCGGAG
Seq A exon
GTGAGTGGGACCTCGGGGACTCCGGTCCTCCTAGCCTCCAAAGGAGAGAGTGGGGGCGCCAGACCTGCCTCGGGCCACCCTGCTGGGAATCGCCCTCCAGGAAGCAATTTTGAAAATTACCTAGGAAGCCTGCACCCCCAGCCCTCCCGGGCGCATCATCTGGAGCCCAGCAGTCACCTTTACCAGGACTCACCAGTATCCGCAGGCAGCCCTTGTGGCAAACCCACCAACCCACACTACTAGGGGTAGAGTGGCTCTGCCCTCACCTCACAGTGATGCCTGCCTGGCCAGGAAAAGTGGCTCCCAAGCCTTCAGCCTTCCAACTCTTCCTTCCTTCTTACCACGTGTCCTCCTGTCAGGTCCCACCCCACACCACATCCCTTCTCCTGCTAGAGCAATTGTCCCTGTTTATAGAATAAAGCTCAGCCCCTAAGTGTTCTTGTCCTTGACTGTGGCATGTGGAAAGAGCCAGGAAAAAGGGGACGTCGCCTCGTGGCTCCAGCAACCCTGGTGCCTGGTCCCTTCCTGTCTCACTGGACCCTGCCTCTTAGGGTCAGTGGCTCCTGGCCTCTCCTCCTGACCACTGAGATGCTGGATTCCCAGGCAGAGGTTTTCCTTCCTTGGGCCATAGTTGATTTATCTGGCAATGGGGGTAATAATAGCTGTCGGCCTCACTCTGTAAGGCACTAGATTATGAGGCCATTGCTTTGGACCCTTCAGGTGAGAGGGGCTGTTCGCCTGATGCTTGATGAAGGGAACTCCGGGAAGCAGGAGGTCTGGGTTCCAGGCCCTTTTGGCCTTCATTAGCTAGCAATTCACTTCCTCTTTCTCAATGCCCTGCAAGCTCAGTGCCCTGCAAGCTTCTGGGTCATGGCAGGGGGGTAGGGCCTGGACTTTGGAGCCAAACAGACTTGGTTTCTGTACCAGTCACTTGAGCCCTTTAAACCTCTTTCCTCATTTGTGAAATAGGGGTAATATTGCCCACCTCATAAAAGGCCGTAATAACATATGTGAAATCCCTAGCACAGGGCTGAGCAACAGTAGGTGCTCAATAAATGGTGGCTAACCACAACAATACTGATATTTCTACTTTGGGAGGCCGAGGCGGGAGGACTGCTGAAGCCCAGGAATTCCAGACCAGCCAGGGCAATGTAATGAGACCCTGTCTCTACAAAAAGATTTTGAAAATTACCCAGGTGTGGTGGCGTACACCTGTAGTCTCACAGGAGGCGGAGGCATGAGGATTGCTTGAGCCCAGGAGTTTGAGACTGCAGTGAGCATGATCTCACCACTGCACTCCAGCCCAGGCAACAGAGTGAGATCCAGTTTCAAAAAAATAAAAATAAAAAAACCTGGCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGTCGAGGTGGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATGCAAAAATTAGCTGGGTGTAGTGGTGGGTGCCTGTAGTCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTCGGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCGACAAAGCAAGACTCCACCTCAAAAAAAGAAAAAAAACCCACAAGTCCCAAAACCAAAACTGGTATTTCCCATGTACATTCGACCTTAACTGTTGCTCATTCAACCCAGCCCAACTCAGTGCCCCATCCCCTGGCCCTGAAGAGACCATTCTGGCCCAGATGTGTCCTGGCTTGGAGTAGCACCTTCTGCTACCACACTAGGCCTCCACTCTCCTCAGTGCCCAAGGGGAGGCACCTCACTCTGATCTCCCTGTGGGGTCCTCTTATGCCTGCCAGTAAGGATAGGAGTTTGGTTCTAGAGCAGAGTGGTCTGGCTTCCAACAAGCCCAGTGTTCTAGGTGACCTCAGGTTGCCCCAGGCCTTCCTGTAGGTTGGCACTAATTGGTTTGGCTGCAGCTCCACTTATTAAGTAGTTATTTTTATTACTAACAACCTAGGCAGGGTGGCCCAGGAGCCCGCTGGGGGAGGCGGTGCCAGGCTCCTGGCTGAGGGGCAGGCTGGCCCCAATTCTGACTGGCTGGCTCCAGTGATCAGGACCAGGGCCCCACGTGGTGCTTTGCTGGAGATCTAGGCTTGGTGGGGCAGCTGTGGGGTAAGGGGCAGGACCAGCTCAAAGATGGGGTGGGGGCGGAGGCTGCCTCTGCAGGGCAGAGTCCTTTGGCAGTCGGGACTGTTGGGCATAGAGGAGTCAGCTCACAGCTCAGGGCCAGAGCACTGGAGAGGTCTCTGGGGTGCATACAGGAACCAGGAGTGGAGCTGAAGCATGTCCTATCCCCTGCCAGCCCTCCCTTAGTAACAGCTGGCATTTCTCGAGTCCTTCCTGAGCACCAGGCACCGTGTTATGTATGCAATTTGCAAATATTATCTGATTAAATGCTCACAATAAGGCTATCAGAGAGGTACTATTATTATCCTTATCTTATTATTATTATTATTATTATTTTTAAGAAGGAGTCTTGCTCTGTCGCCCAAGCTGGAGTACAATGGCGCCATCTCTGCTCACCGCAACCTCTACCTCCAGGATTCAAGTGATTCTCCTGCTTCAGACTCCCAAGTGGCTGGGACTACAGCTTCCTGCCACCGCGCCTGGCTAATGTTTATATTTTTAGTACAGATGAGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAAGCGATCCACCTGCCTGGGCCTCCCAACCCTGAGGGTTTTTGTTTTTGTTTTTGTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCCAACACCCCCATGCCTGGCTAATTTTTTTGTGTGTGTTTTCAGTAGAGACGGAGTTTCACCATGTTAGCCAGGATGGTCTCCATCTCCTGACCTCGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTAGGATTATAGGTGTGAGCCACCACGCCCAGCCCCTGAGGTTTAATAATAGGTGCCAGGCCAGGTGGTTAATAGAAGTCTGGGGCATTGTAGGGGGACAGAGGAGGATATATGTCCCCATTGGCCATTGTAGACTCCCTTCCACAAAAAGGACGTCAGTGAAGTGACATGCCCACCTCTACCCCACCCTCCTCCCAGTCCTGGGCACTAGGGCTGCTCCCCAGGTGTTCTGTACCCCCTCCCCACTCTGTCCCATGCCCTGGCCTCTGCCCTCTTTCAAAACATAGATGTGGCTGGCGCCTAGGCTCATGCCTATAATCTCAGCACTTTGGGAAGCTGAGGCTGGAGGACAGCTTGAGCCCAGGAATTCAAGACCAGCCTGGGCAACATAGTGAGACCCTGTCTCTACCAATTATTTTATTTTATTTTATTTTGTTCATTTATTTATTTATTTTGAGACAGAGTTTTGCTCTGTCACCTAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGAACTACAGGCGAGTGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACCAGGTTTCACCATGTTGACCAGGATGGTCTCTGTCTCCTGACCTCATGATCCACCCACCTTAGCCTTCCAAAATGCTGGGATTACAGGCATGAGCCACCACTCCCAGTCCTATAAAATTTTAAAAAAATGTCTGGGTGTGGTGGCGCATGCTTGTAGTCCCAACTATTGGGGAGGCTGAGGCAAGAGGATTGGTTGAGACCAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACCGCACTCCAACCTGGGTAACAAAGTGAGACCCTGTGTCTAAAAAAGAATTTAAAGGCCGGGTGTGGTGGCTCACACCCGTAATCCCAGGACTTTGGGAGGCCGAGGTGGGCAGATCACGAGGTCAGATTAAGACCATCCTGGCTAACAAGGTGAAACCACGTCTCTACTGAAAAAAAAAAATACAAAAAATTAGCCAGGCATGGTGGTGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAATCTGGGAGGTGGAGCTTGCAGTGAGCCAAGATCCTGCCACTGCACTCCAGCCTGGGTGACAAAGAGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAGAATTAAAAAAGATTTTTTTAATGAACAAAACAGGCTCGGCACAGTGGCTCATGCCTGTAATCCCAAGCACTTCGGGATGCCAAGGTCAGGGGATCACCTGAGATCAGGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAACTCAGCCAGGTGTGGTGGCACACGCCTGAAATTCCAGCTACTCGGGAGGCTGAGGCAGGAAAATTGGCTTGAAGCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGTGAGACTCTATCTCAAAGAAAACGAACAAAACATAGATGCCTACATACCATTCCTCTGCCCTTGGCTCCTGGGGAGTAAGGGATCACCCAGTGACCTCCTAGAAGGCCAGTGACAATGGGGGGTGTCAGGGTGCTTTTCAGAGCCAAGGGAGTGGTAGGAATTGGGATCTTAGTCCAGCTCCAAGCTGTGAGGGAGAGAGTTGCAGGGCACTTAAGCTTGGTGGAGACCCTCAAGGCCTCTTTGCCTGTCCCTGCAGCAAAGGTTCTGGACACCAGAGCCAAGTCCAGAAGCCCTGGTGGAACAGGGGTGAAAAGCATAGGTTCTGACTTCAGACTGCTGGGCCGCAGCCCTGGCTATCCCACCCCAGGTGAGAGCAGGCTGCTCTGTGCCTCAGTTTCCCCATCTTCATAGTGGAATTGTATTGGTGCCTACCCAGAGGGTTGTGTCAACAATTAGGATGGCACCTAGCACCTTGGTCAGTGGTGGGAAAGGTTCCAGAAGTTCTGCTGTGGTCCCAGGGGTGTCTCAGGCCCTGCCATCATCTCCTTGGAGGGGTGCCATGTGGTGGGAAAGAACCCCAACTTCAAGGCCACACACAGTGGCTCATGCCTGTAATCCTAGCACTTTCAGAGGCCAAGATGGGAGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAATGATACAAAAATTAGCTGGGTGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGTCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGCAGAGTTTGCAGTGAGCTGAGATGGCACCACTGTACTCCAGCCTGGCCGACAAAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAGAACCCAAACTTTTGGTGTTCAGCCATGTTCCCATGCTCACTCCCAGGGTGGTGACTCTGGGAAGGTCTCAGCCTCCTTGTCTGCCCAGTTAGAATGATCTGATGCCCCTGCTACCATCAGACTTGATAAGTTTCCCAAAGACTCTTTGCAAGAAGCACTGTTCTGGAGGGTGGAGGAGAGACTAATTGTTCTTGCTCTCCTGGCCAG
Seq C2 exon
AGTGGGAAGCTTTGGGGTGGCCGGTTTGTGGGTGCAGTGGACCCCATCATGGAGAAGTTCAACGCGTCCATTGCCTACGACCGGCACCTTTGGGAGGTGGATGTTCAAGGCAGCAAAGCCTACAGCAGGGGCCTGGAGAAGGCAGGGCTCCTCACCAAGGCCGAGATGGACCAGATACTCCATGGCCTAGACAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000126522-ASL:NM_000048:2
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.031
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0020615=Lyase_1=PU(19.7=89.2)
Main Inclusion Isoform:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)