HsaINT0048744 @ hg19
Intron Retention
Gene
ENSG00000006377 | DLX6
Description
distal-less homeobox 6 [Source:HGNC Symbol;Acc:2919]
Coordinates
chr7:96635290-96637143:+
Coord C1 exon
chr7:96635290-96635725
Coord A exon
chr7:96635726-96636949
Coord C2 exon
chr7:96636950-96637143
Length
1224 bp
Sequences
Splice sites
5' ss Seq
CAGGTGAGA
5' ss Score
9.22
3' ss Seq
TCTGTATTATTTGCTTACAGATC
3' ss Score
9.1
Exon sequences
Seq C1 exon
ATGATGACCATGACTACGATGGCTGACGGCTTGGAAGGCCAGGACTCGTCCAAATCCGCCTTCATGGAGTTCGGGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAACAGCAACAGCCGCCGCCGCCGCCGCCGCCGCCGCCGCAGCCGCACTCGCAGCAGAGCTCCCCGGCCATGGCAGGCGCGCACTACCCTCTGCACTGCCTGCACTCGGCGGCGGCGGCGGCAGCGGCCGGCTCGCACCACCACCACCACCACCAGCACCACCACCACGGCTCGCCCTACGCGTCGGGCGGAGGGAACTCCTACAACCACCGCTCGCTCGCCGCCTACCCCTACATGAGCCACTCGCAGCACAGCCCTTACCTCCAGTCCTACCACAACAGCAGCGCAGCCGCCCAGACGCGAGGGGACGACACAG
Seq A exon
GTGAGAGGCCGCTGGGGCAGCTCGCTTCTCCCGCCTCCCGACTGCCCCCTACCCCGCCCGCCCGCTCACTTCCTCGACGCCCGGGCCTCCGCCGGCCCCCTCCCCCAGGCGGCCCCGCGCGCCCTTGGCCGGGCCCCGTGCGCGCCCGCTCGCCTGGCGCCTGCCTGCCGGCCTCTCCCAGCCGGGCCCCTTCCCGCCGCCGCGGACCCTCAGCTTCCGACGCGCAGTTCGGGCTGAGTCCCGGGCCCGGCGCAGGCTTCGTTCGACGAGTTAGTCCACACTGCGCTCTCCAGCCTCCTGGGTCTGTGCGCCCTTTTCCTTGCTCCTTCCCTCCAGGCTGTAACCCACGTTTGACCCGGCTGGGGACATTTCTGGGCCGGAACTGGGGAGCGTGTTTTGCTTCCCAGCCCACGCTGGGCAGGCAGTGGCCTACTTTGCGTGGGGCGCCCCGTGCTCCTCAGTGACTCGGAGGGAAGCTGGCCTGGCTTTCGCTCTGGTTAAACTAGTAACAGTCAGGCTCTTTCCAGTGGGCTTTAAAGTGTCCCTCACCTTCATCCCTGACCGGGCCCCCTATCTAGCTTTTCGCTACAGTGTTGGCTGCTCCTTTGTTCGTGGAGGGGAAGCAAAGAACCTCGGGCTGATGGTTCTCAGCACCCGAGGGGGACAAAGTTGCCGTGAGAGGCGCAGCCTGCTCGTGGGCTGGTCTGAGCTGTTGGTTGTGTTTTGTTTGAGGATTTGGTCCTCCTCAGGAGAGTCATTTCAAAACATGCCGAGGATGCTTGATGCACTGAGCTTGGAGCTGGTGACATCAAGTCAACTGGCCGCGTAAACACCTGGGTGGCTCAAGCACAGCTTCAGGTACTGTTAAGCCGGGCACAGGGGCCCCGCTCCGCCCGGACAGCTGCCGCCTTGCTGCGCTGCGCACCCCAGAGAGCCTCCGGCACCGCCTCCGCTGCGGCAAAGCGGGCTGTTTGTCTGAGGGCCTCTGGCGCTCCCTTGGCCCAGACGCTGCACATTGTTCGGGCCAGGGACTGGGTCAAGGAGATTACGCAGACGCTGGGAGCACACGGGCAGAGTGGACCAAGAGAGGTCGGGGCATCATAGGGATTTTTCGAGGTAACCCTTATTGGGCTTTGGGGAGACTCGTTGCATGCCACGCCAGGAGCAGGGAGATGGCAGCAGTAGCCTCCCGGGTGACCGCTCCTCTGTATTATTTGCTTACAG
Seq C2 exon
ATCAACAAAAAACTACAGTGATTGAAAACGGGGAAATCAGGTTCAATGGAAAAGGGAAAAAGATTCGGAAGCCTCGGACCATTTATTCCAGCCTGCAGCTCCAGGCTTTAAACCATCGCTTTCAGCAGACACAGTATCTGGCCCTTCCAGAGAGAGCCGAACTGGCAGCTTCCTTAGGACTGACACAAACACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000006377-DLX6:NM_005222:1
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.908 A=NA C2=0.379
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0004624=Homeobox=PU(73.7=64.6)
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACTACCCTCTGCACTGCCTG
R:
AGCGATGGTTTAAAGCCTGGA
Band lengths:
354-1578
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)