HsaINT0114894 @ hg38
Intron Retention
Gene
ENSG00000074181 | NOTCH3
Description
notch 3 [Source:HGNC Symbol;Acc:HGNC:7883]
Coordinates
chr19:15170671-15174400:-
Coord C1 exon
chr19:15174068-15174400
Coord A exon
chr19:15170826-15174067
Coord C2 exon
chr19:15170671-15170825
Length
3242 bp
Sequences
Splice sites
5' ss Seq
CGGGTGAGT
5' ss Score
9.89
3' ss Seq
CCTCCCTGCTGTCCCTGCAGCTC
3' ss Score
11.94
Exon sequences
Seq C1 exon
CCCGGTGTACGAGAAGTACTGCGCCGACCACTTTGCCGACGGCCGCTGCGACCAGGGCTGCAACACGGAGGAGTGCGGCTGGGATGGGCTGGATTGTGCCAGCGAGGTGCCGGCCCTGCTGGCCCGCGGCGTGCTGGTGCTCACAGTGCTGCTGCCGCCAGAGGAGCTACTGCGTTCCAGCGCCGACTTTCTGCAGCGGCTCAGCGCCATCCTGCGCACCTCGCTGCGCTTCCGCCTGGACGCGCACGGCCAGGCCATGGTCTTCCCTTACCACCGGCCTAGTCCTGGCTCCGAACCCCGGGCCCGTCGGGAGCTGGCCCCCGAGGTGATCGG
Seq A exon
GTGAGTGACCCCACCTGGAAAAGCCGTGGTGGCTGGGGAGAGGAGAGATGCTGTTGATCCAGGTCTTGTGTGTTTCATTTCACTTAATGCCTTTACCCACCAGATGTCAGGAGCACCGCCTCCTGGCTGTGACAAGCAAAAAATGCCTCCAGATGGAGCTAGTGCTTCTGGGGTAGAATTGCCCAGGTCTAGTGCTGGCTTGTGGGGAGGCAGGTTGCTAAGTGGCTTGGCAGAGTGGTTAAATACATGTGTAGGGTTTTTTTCTTCTTCTTCTTCTTCTTCTCCTTCTCCTTCTCCTTCTCCTTCTCCTTCTCCTTCTTCTTTTCTTTTTTTTTTTTTTTTTGAGACGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGCATCCACCACCACACCGGGCTAATTTTCTTCTTCTTAAAGACATAGAAGATAAAGCCGGGCACAATATATTCTTGTAGTCCCAGCTACTTGGAGGATCACTTGAGCCCAGGAATTCAAATCTAGCCTGGGCAACATAGCAAGACTCCCATCTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGAGTGCAGAGGCGCGATCTCGGCTTTCTGCAAGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGGCCGCCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAAGAGACGGGGTTTCAGTGTGTTAGCCAGGATGGTCTGGATCTCCTGACTTCGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCTCCGATCTCTTAAAAAAAAAAAAAAAAAAAAAAAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAGGGAGGAGGGAGGGGGAGGGGGAGGGGGAGGAAGAGGAAGAAGAAGGAAGAGGGGGAGGGGGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAAGAAATAGGAGGGGCTCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGAAGGCAGTTCATTTGACGTCAGGAGTTTGAGACCAGCCTGGGCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGTGTATGCCTTTAGTCCCAGCTACTCAGGAGGCTGAGGCATGAGAATCACTTGAACTCAGGAAGTGAAGGTTGCAGTGAGCCAAGATTGTGCTACTGCACTCCAGCCGGGGCAACAGAGCCAGACTCTGTCTCAAAAAAAAAAAAAAAGAAAAAGAAAAAATATAGAAGTATCCTGCTAGTGGCCTGGTAGAGGTACCAGAAGGGAGGTGTAGCTATTGTTGAGGAGAAGGCAGAGACCTGAGAGGGGTGGGTCTCTGATACAGAGAGGAGGGTTGGGTTTTGCAGATATTGGGATGTGGGTGGTGGAAGGGGAGGGGTAGAGGGATGAAGGAGAGTGGTTGGTGTACCAGCCCCTGGCTAAGCTGAGTGATAGGGCCACAAAGTGAAAAACAGGTCATTTTGGAGCTTGCAGAGTCTGAGGGACCTGGAAGTATTGGGAAGGCCTCCAAGGAGATACCTGGGGGCTAAAGACACAAACAAGAAAGATATAAAAGTGTTGATGATCATTGAAGCCATGAGAGGGACTCAAAGGAGTGGGGAGAGAAGGAACAGAAGAATTAATCTGGGGACACGGAGACCTAAGGATTGGATGAATGGAATTAGCTCAAAAAAGAGGAAGAGGCCAGGTGTGATGGCTCACAACTGTGATCCCAGCACTTTGGGAGGTTGAGGCGGGTGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACATGGAGAAACCCTGTGTATACTAAAAATACAAAATTACTGGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCCTGAACCCTGGACGTGGAGGTTGTGGCGAGCTGAGATAGCACCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCTGTCTCAAAACAAGCAAACAAACAAACAAATACAATGTCCTGGCCAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTACCTGGGCGTGGCAGCGCGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAGAATCACTTGAACCAGGGAGTCGGAGGTTGCAGTGAGCTGAGATTGCACCACTGCACTCCAGCCTGTCGACAGAGCAAGACTTCATCTCAAAAACAAAAAACAAACAATGTCCCTTGGCTGGGCGTAGTGGCCCAGGCCTGTAAACCCAGCACATTGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCCGGAGTTCAAGACTAGCCTGGGCAACATAGTGACACCTAATCTCTATGCCTCCACCCCCAACCCCCCCCAAAAATTAGCCAGGTGTGGTGGCACATGTCTGTGGTCCCAGATCTTTGGGAGAATGAGGTGGAAAGATTGCTTGAAGGCGGGAGGTCAAGGCTACAGTGAGCTCTGATTTCGCCACTGTGCTCTAGCCTGGGCGACAGAGTGAAACCGTCTCAAAAAACAAAACAGAACAAACAAACAACAAAAAAAACAGGCCAGGCACAGTGGCGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGGAGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACGTGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACACGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGGGAAGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTCGGTGCAAGATCAAAAAATAATATCCATTGGATTCATGGCTCTGGGGGGACTGCTGACCACAGCAAGACACGTTTTAGGGGTGCAGTGGGGTTGGATGCCAGGTGGATGCAGGTGGGCCATGGAGACCTGTGGGTGGAGATGGCGCTTCAGAGCCAGGCGCTGGGGAGGGAAAGTGGGGCTTGGTACCAGGGGGTGCATCGGGCAATTTTTGAGCCCTCTGGTCCCTCCCTGCTGTCCCTGCAG
Seq C2 exon
CTCGGTAGTAATGCTGGAGATTGACAACCGGCTCTGCCTGCAGTCGCCTGAGAATGATCACTGCTTCCCCGATGCCCAGAGCGCCGCTGACTACCTGGGAGCGTTGTCAGCGGTGGAGCGCCTGGACTTCCCGTACCCACTGCGGGACGTGCGGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000074181:ENST00000263388:25
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.098 A=NA C2=0.057
Domain overlap (PFAM):
C1:
PF0006612=Notch=PD(82.5=29.5),PF068168=NOD=WD(100=50.9),PF076847=NODP=PU(4.6=2.7)
A:
NA
C2:
PF076847=NODP=FE(80.0=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development