Special

MmuEX0026872 @ mm9

Exon Skipping

Gene
ENSMUSG00000027070 | Lrp2
Description
low density lipoprotein receptor-related protein 2 [Source:MGI Symbol;Acc:MGI:95794]
Coordinates
chr2:69337249-69338844:-
Coord C1 exon
chr2:69338667-69338844
Coord A exon
chr2:69338158-69338239
Coord C2 exon
chr2:69337249-69337377
Length
82 bp
Sequences
Splice sites
3' ss Seq
CTCTCCTCAAATCTCTCCAGTGG
3' ss Score
6.82
5' ss Seq
CAGGCGAGT
5' ss Score
2.92
Exon sequences
Seq C1 exon
GTTCTCCACCATCCGCACGCTCTTACTCTGTTTGAAGACTCTGTGTTCTGGACTGACCGCGGCACTCACCAGGTCATGCAGGCCAACAAGTGGCACGGGAGGAACCAATCTGTTGTAATGTACAGCGTTCCCCAACCGCTCGGAATAATTGCCATCCATCCCTCCAGGCAACCATCTT
Seq A exon
TGGTGTCTCACAGTCTGGCCCTGTTTCTTCTGTGGCTTACATTCACCACGCTGGACTACATCATGGTCCAGTGACGCACCAG
Seq C2 exon
CCCCGAATCCATGTGCCTCTGCCACTTGCAGCCATCTTTGCCTGCTTTCTGCACAGGAGCCTAGACATTACTCTTGTGCTTGTCCCTCAGGGTGGAACCTTTCTGATGATTCTGTCAACTGTGTGAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000027070-'35-33,'35-32,36-33
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
ORF disruption upon sequence inclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.013 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0005812=Ldl_recept_b=PD(25.6=18.3)

							
A:
NO

							
C2:
PF146701=FXa_inhibition=WD(100=84.1)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000079752f2044A





     
                   









    
Main Skipping Isoform:
ENSMUSP00000079752f6174A





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
ENSMUSP00000079752, ENSMUSP00000079752f2045A
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
No conservation detected
Human
(hg19)
chr2:170089272-170089375 
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
chr2:27000921-27001006 
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AATGTACAGCGTTCCCCAACC

				
R: 
CAGAAAGGTTCCACCCTGAGG

				
Band lengths: 
167-249

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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