Special

MmuEX0044974 @ mm9

Exon Skipping

Gene
ENSMUSG00000063919 | Srrm4
Description
serine/arginine repetitive matrix 4 [Source:MGI Symbol;Acc:MGI:1916205]
Coordinates
chr5:116903418-116917597:-
Coord C1 exon
chr5:116917441-116917597
Coord A exon
chr5:116904682-116904697
Coord C2 exon
chr5:116903418-116903722
Length
16 bp
Sequences
Splice sites
3' ss Seq
TTACACCTTTCCTACTAAAGGAG
3' ss Score
5.24
5' ss Seq
TTGGTAAGT
5' ss Score
10.47
Exon sequences
Seq C1 exon
GCATCGAGGTCGGTCCCCTGAGGAAGGGCGGAAATCCCGCCGAACACACTCCCGCCGCTGCTCCAAGAACCACTGCAAGGTCAGCCCAGACGCCCGGTCCAGCCACCTGCCCAGCCAGCCCCTCCCGAGGCTCGGCTTCCTGTCAGCCAGGGGTGTA
Seq A exon
GAGGAGTCCTTGCTTG
Seq C2 exon
ATCACTGGGTCGGGGTCCGCGGCTGACCTCTTTAGCAAATCGGCCAGCCCTCTCGCCGCCACCCGAGGGCGCTCGCAGGAGTACGACTCGGGCAATGACACGTCCTCGCCGCCCTCCACGCAAACCAGCTCGGCCAGGTCTCGGGGCCAGGAGAAGGGGAGTCCCGGTGGGGATCTAAGCAAGAGTCGAGACCTCAACTGTGGCAACACCTCCGATTCAGGGAACTCCTTCACCACCTCCTCCCCCCAGAACAAGGGGGCTGTCTTGGAGACTGTCTCTCCCGCCTGCAGGAGCAGAGAGTCAAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000063919-'7-9,'7-7,8-9
Average complexity
S
Mappability confidence:
100%=75=100%
Protein Impact





	

	
In the CDS, with uncertain impact





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.981 A=0.333 C2=0.962
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
NO

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000075488f5291A





     
                   









    
Main Skipping Isoform:
ENSMUSP00000075488





     
      









    
Other Inclusion Isoforms:
NA
          









    
Other Skipping Isoforms:
ENSMUSP00000120474
  



Associated events







Conservation


Human
(hg38)
No conservation detected
Human
(hg19)
chr12:119582344-119582359 
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
chr17:58449093-58449108 
ALTERNATIVE
BtaEX0034603
(SRRM4)
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
chr15:10001334-10001349 
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
TGCTCCAAGAACCACTGCAAG

				
R: 
GGACCCCGACCCAGTGAT

				
Band lengths: 
117-133

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 1 annotated functions for this event 


PMID: 27984743
This event
Introduces a PTC. Increases with activity and contributes to downregulate nSR100


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types






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