MmuEX6000985 @ mm9
Exon Skipping
Gene
ENSMUSG00000037236 | Matr3
Description
matrin 3 [Source:MGI Symbol;Acc:MGI:1298379]
Coordinates
chr18:35721812-35737273:+
Coord C1 exon
chr18:35721812-35721946
Coord A exon
chr18:35731497-35732589
Coord C2 exon
chr18:35737212-35737273
Length
1093 bp
Sequences
Splice sites
3' ss Seq
AACTGCTTATTTTTCTACAGAGT
3' ss Score
7.77
5' ss Seq
AAGGTGAGT
5' ss Score
10.47
Exon sequences
Seq C1 exon
GGGCGCTCTCGCGAGATTCATCTCTGGTTCTGTCGCCACCTCCTGCCAGCGCCGTTGCTGCGGGGGATTGTGGGAGCCTCCGCGTCCCGCTCGCTGAGAGAGGTATCTCTCCTTTTCCCTCTCCCTTCCCCTCAG
Seq A exon
AGTTGTCTGCTGGTTCTCAGCTTGAAGAAGATTCTACAGTCCTTATTGATCCTTTTTCTTGGCGTTACCATTTTTGAAGCAAAGTTAACCTAGCTTTCTAGCTTGAGCTTTCTTTTTGGCCATCTTTTAAAACTTTTTTTTTTTTTTTTGATCTATAAAATAGACAAGAGATAGTTCTACAATGTCCAAGTCATTCCAGCAGTCATCTCTCGGTAGGGATTCACAGGGTCATGGGCGTGACCTGTCTGCAGCAGGAATAGGCCTTCTTGCTGCTGCTACCCAGTCTTTAAGTATGCCAGCATCTCTTGGAAGGATGAACCAGGGTACTGCACGCCTTGCTAGTTTAATGAATCTTGGAATGAGTTCTTCATTGAATCAACAAGGAGCTCATAGTGCACTGTCTTCTGCTAGTACTTCTTCCCATAATTTGCAGTCTATATTTAACATTGGAAGTAGAGGTCCACTCCCTTTGTCTTCTCAACACCGTGGAGATACAGACCAGGCCAGTAATATTTTGGCCAGCTTTGGTCTGTCTGCTAGAGACTTAGATGAACTGAGTCGCTATCCAGAGGACAAGATTACTCCTGAGAACTTGCCCCAAATTCTTCTACAGCTTAAAAGGAGGAGAACTGAAGAAGGCCCTACATTGAGTTATGGTAGAGATGGCAGATCTGCTACACGGGAGCCACCATACAGAGTACCTAGGGATGATTGGGAAGAAAAAAGGCACTTTAGAAGAGATAGTTTTGATGATCGTGGTCCTAGTCTCAACCCAGTGCTTGATTATGACCATGGAAGTCGTTCTCAAGAATCTGGTTATTATGACAGAATGGATTATGAAGATGACAGATTAAGAGATGGAGAAAGGTGTAGGGATGATTCTTTTTTTGGTGAGACCTCGCATAACTATCATAAATTTGACAGTGAGTATGAGAGAATGGGACGTGGTCCTGGCCCCTTACAAGAGAGATCTCTCTTTGAGAAAAAGAGGGGCGCTCCTCCAAGTAGCAATATTGAAGACTTCCATGGACTCTTACCGAAGGGTTATCCCCATCTGTGCTCTATATGTGATTTGCCAGTTCATTCTAATAAG
Seq C2 exon
GAGTGGAGTCAACATATCAATGGAGCAAGTCACAGTCGTCGATGCCAGCTTCTTCTTGAAAT
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000037236-'11-6,'11-4,19-6=AN
Average complexity
A_C1
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion (Ref, Alt. ATG (<=10 exons))
No structure available
Features
Disorder rate (Iupred):
C1=NA A=0.682 C2=0.286
Domain overlap (PFAM):
C1:
NA
A:
NO
C2:
NO
Main Skipping Isoform:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Rat
(rn6)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCTCTCGCGAGATTCATCT
R:
TCAAGAAGAAGCTGGCATCGAC
Band lengths:
190-1283
Functional annotations
There are 1 annotated functions for this event
PMID: 31911676
[CRISPR screen]. Conserved poison exon with pro-oncogenic impact when depleted: HeLa Enriched at 14 days (FC=1.631, FDR=0.000), PC9 Enriched at 14 days (FC=1.290, FDR=0.000), Late Xenograft No change (FC=1.451, FDR=0.059).
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
Other AS DBs: