DreEX0045219 @ danRer10
Exon Skipping
Gene
ENSDARG00000000394 | matr3l1.1
Description
matrin 3-like 1.1 [Source:ZFIN;Acc:ZDB-GENE-030616-40]
Coordinates
chr14:24797312-24802743:-
Coord C1 exon
chr14:24802624-24802743
Coord A exon
chr14:24797796-24798693
Coord C2 exon
chr14:24797312-24797373
Length
898 bp
Sequences
Splice sites
3' ss Seq
GCTCCATTGTGTTTCTGCAGACG
3' ss Score
9.08
5' ss Seq
ATGGTAAGT
5' ss Score
11.01
Exon sequences
Seq C1 exon
TTTCACGTTCGCGGTTGTTTCCGCTTTCACGCTGTGCGCATTTGCCCCACTGTTTGATCGTGTTTCGCTTCGTGAGACGTAAAGGATTTTTAACTCGAGGGTTGGAAGTAAGAAAAAAAT
Seq A exon
ACGTGTTTCATTCTGGAGGAGCTCTTTTCTCGATCCAGGCTTAAATCCACGGATTGTCCTTTTGGGGACTTTTTGATTCGCTTTATTCCTCTCTTTTTCCACTCATCTGGAGCACCGTCATTTCAAGGCCATGTCTCAGAAATTGACCAGCGATGATCTTCAAAAAGGCTTTGCTGTTGGCCGCGGGCTTTTGGCTGCTGCTGAGACTTTGAACTTTAGCATGGGTGAGACGCACTCTGACCACTTTGGCTCGTCTTCACAGTCACGTGGTGGCATGTCTGGCTTGGGTGGAGTGGATGGCAAAGACCATGAATCTCAGCTTTCCCGCCGAGCAGGCAGCCACATTAGCAATACTATGAAACTGTTTGCCAGCCTAGGTCTGTCACCAAGTGATCTGGATGCACTGGCACAGGTTCCAGAGGAGAACATCAGTGTGGAGACTTTGCCCCATCTTATTATGCAACTTAAAAATCGCAAGATGGAAGCTGGCCGCCGAATGTCTGGTGATATCTCTACCCATTCTTCCGAGACTTCATACAGAGGTGGCCGAGATACCTGGGGTGAAGGGCAGGGTGGACGATTGGACCGTTCCAGTGGCCAGTCACAAAGTCGTTCCCAAGGCAACTTCAGTTATTCTTCCATGCAAGACACTTCCAGTCGTGGATACGACATATTAGATTACGGCAGCGGTAGTGGAAAAGACCGCCAATATTCTGAGCTTTCCCATGACTCCTACCGCAGCCTTGGTATGTCTTCATCATCAACATCTGACGATATGTTCATGCAAAGAAGAATGGGCGCCCCGTCTCAGGGAAAAGTGCAGGATTTCTTGGGAGTCAGGCCGCTCATGTTTCCTCATATGTGCACCCTTTGTGATTTTGATGTGCACTCTGTCATG
Seq C2 exon
GAATGGACTCAGCACACAGCTGGGATTCGCCACTCTGAAAACCGGCGACTGCTCCTGCAAAT
VastDB Features
Vast-tools module Information
Secondary ID
ENSDARG00000000394-'0-3,'0-2,6-3
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion (Ref, Alt. ATG (<=10 exons))
No structure available
Features
Disorder rate (Iupred):
C1=NA A=0.641 C2=0.143
Domain overlap (PFAM):
C1:
NA
A:
NO
C2:
NO
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Rat
(rn6)
No conservation detected
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 31911676
[CRISPR screen]. Conserved poison exon with pro-oncogenic impact when depleted: HeLa Enriched at 14 days (FC=1.631, FDR=0.000), PC9 Enriched at 14 days (FC=1.290, FDR=0.000), Late Xenograft No change (FC=1.451, FDR=0.059).
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]