Special

MmuEX6025149 @ mm9

Exon Skipping

Gene
ENSMUSG00000026193 | Fn1
Description
fibronectin 1 [Source:MGI Symbol;Acc:MGI:95566]
Coordinates
chr1:71685031-71687902:-
Coord C1 exon
chr1:71687726-71687902
Coord A exon
chr1:71686866-71687018
Coord C2 exon
chr1:71685031-71685159
Length
153 bp
Sequences
Splice sites
3' ss Seq
TCTCCTCCATTTCCAACCAGCCC
3' ss Score
7.27
5' ss Seq
GAGGTATGC
5' ss Score
9.12
Exon sequences
Seq C1 exon
TTTTGGTTCAGACTCGAGGCGGAAATTCCAATGGTGCTCTGTGCCACTTCCCCTTCCTGTACAACAACCGGAATTACACCGACTGTACTTCTGAGGGTCGCAGGGACAACATGAAATGGTGCGGCACCACCCAGAACTACGATGCCGATCAGAAGTTTGGATTCTGCCCAATGGCTG
Seq A exon
CCCACGAGGAGATCTGCACAACCAATGAAGGGGTCATGTATCGCATTGGGGATCAGTGGGATAAGCAGCATGACCTGGGCCACATGATGAGGTGCACGTGTGTGGGGAACGGTCGTGGAGAATGGGCCTGCATCCCCTACTCCCAGCTCCGAG
Seq C2 exon
ACCAGTGCATCGTTGATGACATTACTTACAATGTGAACGACACGTTCCACAAGCGTCACGAGGAGGGACATATGCTGAACTGTACCTGCTTTGGTCAGGGCCGGGGCAGATGGAAGTGTGACCCCATTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000026193-'11-11,'11-10,12-11=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact





	

	
Alternative protein isoforms (Ref)





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
PF0004014=fn2=WD(100=70.0)

							
A:
PF0003913=fn1=WD(100=75.0)

							
C2:
PF0003913=fn1=WD(100=86.4)

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000054499





     
                   









    
Main Skipping Isoform:
NA





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000084509, ENSMUSP00000095306
          









    
Other Skipping Isoforms:
NA
  



Associated events






Other assemblies


mm10




Conservation


Human
(hg38)
chr2:215422091-215422243 
HIGH PSI
HsaEX6018355
(FN1)
Human
(hg19)
chr2:216286814-216286966 
HIGH PSI
HsaEX6018355
(FN1)
Rat
(rn6)
chr9:78955972-78956124 
HIGH PSI
RnoEX6040250
(Fn1)
Cow
(bosTau6)
chr2:103935924-103936076 
HIGH PSI
BtaEX6011330
(FN1)
Chicken
(galGal4)
chr7:4372024-4372176 
HIGH PSI
GgaEX1066055
(fn1)
Chicken
(galGal3)
chr7:4400429-4400581 
HIGH PSI
GgaEX1066055
(FN1)
Zebrafish
(danRer10)
chr1:4835838-4835990 
HIGH PSI
DreEX6029949
(fn1b)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AATGGTGCTCTGTGCCACTTC

				
R: 
CCCTGACCAAAGCAGGTACAG

				
Band lengths: 
248-401

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 5 annotated functions for this event 


PMID: 17591922
MmuEX6025149
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: nuclear magnetic resonance, sequence based prediction. ELM ID: ELMI002211; ELM sequence: NGR; Overlap: FULL


PMID: 18480047
MmuEX6025149
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: nuclear magnetic resonance. ELM ID: ELMI002211; ELM sequence: NGR; Overlap: FULL


PMID: 1532572
HsaEX6018355
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: affinity chromatography technology, coimmunoprecipitation, polyclonal antibody, western blot. ELM ID: ELMI002208; ELM sequence: NGR; Overlap: FULL


PMID: 1694173
HsaEX6018355
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: affinity chromatography technology, coimmunoprecipitation, polyclonal antibody, western blot. ELM ID: ELMI002208; ELM sequence: NGR; Overlap: FULL


PMID: 18480047
HsaEX6018355
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: nuclear magnetic resonance. ELM ID: ELMI002208; ELM sequence: NGR; Overlap: FULL


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]










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