MmuEX6052007 @ mm10
Exon Skipping
Gene
ENSMUSG00000040249 | Lrp1
Description
low density lipoprotein receptor-related protein 1 [Source:MGI Symbol;Acc:MGI:96828]
Coordinates
chr10:127538161-127539562:-
Coord C1 exon
chr10:127539472-127539562
Coord A exon
chr10:127539233-127539377
Coord C2 exon
chr10:127538161-127539090
Length
145 bp
Sequences
Splice sites
3' ss Seq
TGACTCCTGCCTCTCCCCAGGGC
3' ss Score
11.32
5' ss Seq
AAGGTATGC
5' ss Score
9.55
Exon sequences
Seq C1 exon
ATATGGCCTCCATCCTGATCCCTCTGCTGCTGCTTCTCCTGCTGCTTCTGGTGGCTGGCGTGGTGTTCTGGTATAAGCGGCGAGTCCGAGG
Seq A exon
GGCTAAGGGCTTCCAGCACCAGCGGATGACCAATGGGGCCATGAATGTGGAAATTGGAAACCCTACCTACAAGATGTATGAAGGTGGAGAGCCCGATGATGTCGGGGGCCTACTGGATGCTGATTTTGCCCTTGACCCTGACAAG
Seq C2 exon
CCTACCAACTTCACCAACCCAGTGTATGCCACGCTCTACATGGGGGGCCACGGCAGCCGCCATTCCCTGGCCAGCACGGACGAGAAGCGAGAACTGCTGGGCCGGGGACCTGAAGACGAGATAGGAGATCCCTTGGCATAGGGCCCTGCCCCGACGGATGTCCCCAGAAAGCCCCCTGCCACATGAGTCTTTCAATGAACCCCCTCCCCAGCCGGCCCTTCTCCGGCCCTGCCGGGTGTACAAATGTAAAAATGAAGGAATTACTTTTTATATGTGAGCGAGCAAGCGAGCAAGCACAGTATTATCTCTTTGCATTTCCTTCCTGCCTGCTCCTCAGTATCCCCCCCATGCTGCCTTGAGGGGGCGGGGAGGGCTTTGTGGCTCAAAGGTATGAAGGAGTCCACATGTTCCCTACCGAGCATACCCCTGGAAGCTGGCGGCACGGCCTCCCCACCACGCCTGTGCAAGACACTCAACGGGGCTCCGTGTCCCAGCTTTCC
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000040249-'163-152,'163-151,165-152=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. Stop)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.327 C2=0.522
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTTCTCCTGCTGCTTCTGGTG
R:
GAAAGACTCATGTGGCAGGGG
Band lengths:
252-397
Functional annotations
There are 3 annotated functions for this event
PMID: 15115822
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: coimmunoprecipitation, glutathione s tranferase tag, knock out, mutation analysis, pull down. ELM ID: ELMI001560; ELM sequence: EIGNPTYK; Overlap: FULL
PMID: 16382151
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: coimmunoprecipitation, glutathione s tranferase tag, knock out, mutation analysis, pull down. ELM ID: ELMI001560; ELM sequence: EIGNPTYK; Overlap: FULL
PMID: 18381291
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: mutation analysis, nuclear magnetic resonance. ELM ID: ELMI001543; ELM sequence: EIGNPTY; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types