MmuEX7002128 @ mm10
Exon Skipping
Gene
ENSMUSG00000032826 | Ank2
Description
ankyrin 2, brain [Source:MGI Symbol;Acc:MGI:88025]
Coordinates
chr3:126940072-126950756:-
Coord C1 exon
chr3:126950735-126950756
Coord A exon
chr3:126941610-126947807
Coord C2 exon
chr3:126940072-126940146
Length
6198 bp
Sequences
Splice sites
3' ss Seq
TTTTTTCATTCACATCAAAGATG
3' ss Score
4.23
5' ss Seq
AAGGTATTT
5' ss Score
7.64
Exon sequences
Seq C1 exon
ATCGGTATGACATCCGAAAAAA
Seq A exon
ATGATGAGACAGAGTCGACAGAAACATCTGTCCTGAAAAGCCACCTGGTTAATGAAGTTCCTGTCTTAGCAAGTCCGGACTTGCTCTCTGAAGTTTCTGAGATGAAACAAGATTTGATCAAAATGACGGCCATCTTGACCACAGATGTGTCTGATAAGGCAGGTTCGCTCAAAGTGAAGGAGCTGGCAAAGGCCGGTGAAGAAGAGCCAGGCGAGCCCTTTGAAATTGTAGAGAGAGTGAAGGAGGACTTAGAGAAGGTGAATGCGATCCTGAGGAGTGGAACATGCATGAGAGATGAAGGCAGAGCGCGGAGTTCTCAGTCTGAGCGGGAGCTAGAGGAGGAATGGGTTATTGTCAGCGATGAGGAAATCCAAGAGGCCAAGCAACACGCCCCAGTAGAAATCGATGAACACCCATGTATAGAGGTCAGAGTAGACAGAGAGACCAAGGCCAAAGTAGAAAAGGACTCTACTGGGTTAGTGAACTACCTCACAGATGACCTAAATTCATACACTAGTCCTCATGAAAAGAAGCCACACACAGCTCCAGAAAAGTCAGGGGAGACAAGTCAGGCTTCAGCTGTTGGCAAGAGCTCTGAGAGTAATAAGGGGAAGGCCACCTCAGCCGAGGAGAAACAGAGCGCTCAGAAGCAGCTCAAACCAGGCCTGGCGATCAAAAAGCCAGTGAGGAGGAAACTAAAAGAGAAGCAGAAACAGAAAGAGGAAAGCTCGCAAAGCAGCGAAGAAAAGACCGAACTTAAGAAAGGTAGTTCAGAGGAGTCGGTAGATGAAGACCGCGGCCTGGTCCCTGAACCCCTCCCCACTGCCAAGGCCACCTCTCCTCTCATAGAAGAAACTCCTATTGGTTCCATAAAGGACAAAGTGAAGGCTCTTCAGAAGCGAGTGGAAGATGAGCAGAAAGGCCGAAGCAAGCTGCCAGTCAGAGTCAAAGGCAAAGAGGATGTGCCCAAAAGGACCACTCCCAGGACACACCCAGCTGTGTCACCCTCTTCAAAGTCATCGACTTCCTCTAAAGCAGAAAGACACTCTTCCCTTTCTTCCTCCGCAAAACCTGAAAGGCACACACCAGTGTCACCGTCCAGCAAAAACGAAAAACTCTCACCTGTGTCACCCTCGGCCAAAACCGAACGGCATTCACCAGTATTTTCAGGTAAACCCGAGAAACACTCACCTGGTTCCCCCTCAACCAAAAATGAAAGACATTCCCCTGTGTCATCTCTAAAAACAGAACGACACACACCCGGGTCCCCTTCAGGTAAGACAGACAAACGTCCACCGGTGCCATCATCTGGAAGAACAGAGAAACATCCCCCAGTGTCACCTGGCAAAACCGAAAAACACTTGCCCGGTTCCCCTTCTATAAGAACCCCAGAGAAGCCGGCACCTGGGTCTGCCACCGGGAAACATGAGAAGCACCTCCCTGTGTCTCCTGGGAAGACAGAAAAGCAGCCACCCATATCTCCCACCTCCAAAACCGAACGAATTGAGGAGACAATGTCTGTCCGGGAGCTCATGAAAGCATTCCAGTCAGGTCAGGACCCATCTAAACACAAAACAGGACTCTTTGAGCACAAGTCAGCCAAACAAAAACAGCCGCAAGACAAAAGTAAAAGTCGGGTAGAAAAAGAAAAAGGGCACACTGTGACCCAGAGAGAAACACAGAGAATAGAAAGTCAGACAGCCAAGCGTGGCCAGAGATTCCAGGTCTCGGCAGCTACGGAATCCAGAAGGTTCCGTTCTACCACCATCACCGTTGGGCTCAGGATGGAAGATCCAGTTAGAGAAAGGTTTGAGAGAACCCCCATTATTAAAACACCCGAGGTAGTTCCATCAGTGGCGGCAGAAGAGAGCCATCGTGGGAGTGAGAAGATTGTGGATGAGCAGGGAGACATGGACTTCCAGATCAGTCCAGACAGGAAAACCTCCACTGACTTTTCTGAAGTCATCAAGCAAGAGTTAGAAGACAATGACAAATACCAACAATTCCGCCTCACCGAGGACACAGAAAAGGCTCAGGTTCATTTAGACCAAGTAATTACGAGTCCCTTCAACACGGCTTTCCCACTAGATTATATGAAAGACGAGTTCCTTCCAGCTCTGTCTTTACAGAGCGGTGCTTTGGGTGGCAGTTCCGAAAGCCTGAAACAAGAAGTGATAGCAGGCTCGCCTTGCAGCAGCCTGATGGAAGGCACGCCTCAGATCAGTTCAGAAGAGAGCTACAAACATGAGGGCCTAGCAGAAACTCCTGAGACAAGTCCAGAGAGTCTTTCTTTCTCACCAAAGAAAAGTGAGGAACAGATTGGAGAGGCTAAGGAAACTACCAAGGTAGGAACACCCACAGACATTCATTCAGAAAAAGAGCTTCCTATAACTAATGACATTACTGATAGTTCTCAAAAACAAGGTGCTGGGGTCACTCGGGGTTCAGAGCCCTCTACAGAGCATTCTCAGAAGGAGGTCACCCAAGACCCTCACAAAGATGTGTGCTCCAAACAAGATGGCTGCCCTGAGAGCCAGAGTGTATCATTAGCAAGTGAGGTGTTTACTGAGAAAGGGTCCTGTGGTGAAAGTCAGCTTCCACTTGTTAGCTCAGCTTTTAAGACACAATCAGAAAGTGAAACTCAGGAATCCTTAACACCCTCAGAAGTGACAAAGCCCTTCCCACCATCTGATGCTTCCGTCAAGACAGCTGAGGGAACTGAACCAAAGCCCCAGGGAGCTATTAGAAGTCCCCAAGGGCTAGAACTTCCTCTCCCTAACCGGGATAGTGAGGTCCTTAGCCCAATGGCTGATGAATCATTAGCAGTCAGCCACAAAGACTCTCTGGAAGCCAGCCCCGTGCTAGAAGATAACTCCTCCCACAAAACCCCTGATTCTCTGGAACCAAGTCCTCTGAAAGAGTCCCCTTGCAGGGACTCCCTTGAAAGCAGCCCGGTTGAGCCTAAAATGAAGGCAGGAATACTCCCAAGTCACTTTCCCCTCCCCGCAGCTATTGCCAAAACAGATCTTGTTGCGGAAGTGGCCTCCATGCGTTCCCGGCTGCTCCGAGACCCCGATGGCAGTGCTGAGGATGACAGTCTAGAGCAGACATCCCTCATGGAGAGCTCAGGGAAAAGCCCCCTGTCCCCTGACACCCCCAGCTCCGAGGAAGTTAGCTACGAGGTCACACCCAAACCTTCCGATTCAAGTACACCCAAACCGGCTGTGATTCACGAATGTGCAGAAGAGGATGACTCTGAGAACGGGGAGAAGAAGAGGTTCACGCCAGAAGAGGAAATGTTCAAAATGGTAACCAAAATTAAAACGTTTGATGAACTTGAGCAAGAAGCAAAGCAGAAAAGGGACTACAAAAAAGAACCCAGGCAAGATGGGTCCTCCTCAGCCTCGGACCCCGATGCTGACTATTCAGCAGAAGTGAATGACGAGAAACAGATGGCGGGCACAGAGGGGGAGGGGGAGGTCCCTGTCTTGGTGACTTCAGAGAACAGAAAGGTTTCTTCTTCCTCCTCGGAGAGCGAACCTGAGCTGACACAGCTGAGTAAAGGTGCTGACTCGGGACTTCTGACGGAGCCAGTTATCCGAGTGCAACCCCCATCTCCCCTCCCATCCAGCATAGACTCTAATTCTAGCCCCGAAGAAGCAACGCAGTTCCAGCCCATAGTTCCCAAGCAATACACTTTCAAGATGAATGAGGAGATTCAAGAAGAGCCAGCTACTTCAGAAGATAAAGACTGCAAATCACATTTAGCGGAAGACAGTCAGACTCATTCTGCTGATGCTGCTGATGGGTCTGATGGTGACCTGAACAGAGAGACTACTCAGCCAGAGACCTGTGATGGCCATGGTTGTGAGACTGTGAGTCCTAGCAACTCAGCCACTCCTGTCTCCCTAGGAGTTCAGAGTCCAGAGCATAAAGATGTCGATAAGCCCCTGGCCATTGATAAAGACTCACTAGCTCACCAAGATACTTGTGAAAATGACCGAGAAGAAAGAGAGTTTGATCCTTCTGGAGTAGAATCTACTCAAGCAGATCTTCCCAATGAAAGCTCTTCCTTGTCTTCTCGTTGTGCGATACCTGAAGGAAATGAATCAGCTAAAGAAATAGCCTCTCCATCTTCCCCTGTAAAAGTAGAGGTCACGATAACTGACCAGGCTTTGGAGAGCATGCCAGAGGACTGTCCCATTCAAGACTCATCTACTACAATGCAAACAGAGAGGTTTGCCATGGACGTTCCAGTGTCTGAGTTAGCTGAGACTGATGAAAATTCTGACCCTCAAATCATCAGCCCTTATGAAAATGTTCCTTCCTCATCGTTCTTCTCTGCTGAGCCCAGCAAAATCCAAACAGATACCTGTCATAGCACAGTTGTTCATTCACCTGAAGTGTATTCTGTCATCATCAGATCCTCTCCTGAGGATGTGGTAGTGACAAACTCCTCTAACAGAACTGTCTCAGGTGAAGAGTCTCATTGTGAGAGCCACGATCTAGAAACTGAATCCGAGCAAAAAAGTGCTTTGTGGGCCGCGCAGTCTGATGCACCTCCCTTGGCCGTAGCACCCACCGCATCAGATGCAGCATCAGTCACTGGGGAACAAGCAAGCAAAGTCATCATCACCAAAACGGATGCTGATGCTGACTCCTGGAGCGAGATCCGTGAAGACGACGCAGCCTTCGAAGCTCGGGTGAAGGAGGAAGAACAGAAGATATTCGGTTTGATGGTAGACAGGCAGTCACAGGGCACCACTCCTGATACCACTCCTGCTAGGACCCCAACTGAAGAGGGGACTCCGACAAGTGAACAAAATCCATTCCTCTTTCAGGAAGGAAAACTGTTTGAGATGACCCGAAGTGGTGCTATCGATATGACCAAAAGGCCCTATGCAGATGAAAGTTTGCACTTTTTCCAAATCGGCCAAGAGTCCAATGAAGAGGCTATCTCCGAAGACTTGAAGGAAGGGGCCACTGGGGCTGAGCCTCCACAGACGGAGACTACTAGTGAGTCGCTGGAACTTTCAGAACCCAAAGAAGCAATGGATGACGAAGGAGAATTACTTCCTGATGATGTAAGTGAGGAGATAGAGGATTTACCTGCCTCGGATGCTAACATTGACTCCCAAGTGATAATTTCAGCTTCCACAGAAACACCCACCAAAGAGGCTGTATCCACAGCGGTCGAGGAGCCCCCCACCACACAGCGGAGTGATTCTCTGAGCACTGTGAAGCAGACACCACGCCCTGCCGTCCCTGGACCTGTTGGTCAGTTGGACTTTTCCCCCGTCACTAGGTCTGTTTATTCGGGACAGGATGATGAGTCCCCAGAGTCTTCTCCAGAGGAACAGAAGTCTGTGATTGAGATCCCTACTGCACCCGTGGACAACGTGCCTTCTGCCGAAAGCAAACCCCAAATTCCTATCAGGACTCTCCCCACTTTAGTCCCAGCCCCTCCATCTGCAGAGGATGAGAGTGCATTTTCTGATGATTTCCCATCTAGCCTGGATGAGGATAGTAAGGAAGGTGGAGCAAAACCAAAGTCCAAAATTCCCGTCAAAGCACCCACCCAAAGAACTGAGTGGCAGCCCTCCCCTACCGACATACCTCTCCAGAAGACAGCTGTCCCCCAGGGACAGGAAACACTAAGCAGAGCACCAGATGGTAGAAGCAAGTCAGAGTCAGACGCTAGTTCCTTAGATGCTAAGACCAAATGCCCAGTGAAAGCCAGAAGTTACATTGAGACAGAGACGGAGAGCAGGGAGAGGGCCGAGGGGTTTGAGTCAGAATCAGAAGACGGGGCCACAAAACCAAAGCTCTTTGCATCCCGACTGCCGGTGAAGAGCAGGAGCACTTCATCTTCCGGCAGGCCAGGCACGAGCCCCACCAGAGAGAGCAGGGAGCACTTCTTTGACCTTTACCGAAACTCCATAGAATTCTTTGAGGAGATTAGTGATGAAGCTTCCAAATTAGTGGACAGGCTTACACAGTCAGAGAGGGAGCAGGAGCCACCTTCAGACGACGAAAGTAGCAGTGCCCTGGAAGTGTCAGTCATTGAGAGTCTGCCACCTGTTGACATTGAGCACTCAGCTCCCGAGGACATCTTTGACACAAGGCCCATTTGGGATGAGTCTATTGAGACTATGATTGAACGCATCCCTGATGAAAATGGCCATGACCGAGCTGAAG
Seq C2 exon
ATCCCCAAGATGAGCAGGAGCGGATGGAAGAAAGGCTGGCTTACATCGCTGATCACCTTGGCTTCAGCTGGACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000032826-'98-114,'98-108,100-114=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.963 A=0.926 C2=0.411
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
PF0053117=Death=PU(19.0=61.5)
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 31285321
Giant ankB (contains HsaEX0004136) localizes to periodic axonal plasma membrane domains through L1 cell-adhesion molecule protein, where it couples microtubules to the plasma membrane and prevents microtubule entry into nascent axon branches. Giant ankB mutation or deficiency results in a dominantly inherited impairment in selected communicative and social behaviors combined with superior executive function.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types