MmuINT0088298 @ mm9
Intron Retention
Gene
ENSMUSG00000030149 | Klrk1
Description
killer cell lectin-like receptor subfamily K, member 1 [Source:MGI Symbol;Acc:MGI:1196250]
Coordinates
chr6:129566315-129566791:-
Coord C1 exon
chr6:129566687-129566791
Coord A exon
chr6:129566351-129566686
Coord C2 exon
chr6:129566315-129566350
Length
336 bp
Sequences
Splice sites
5' ss Seq
CAGGTACAG
5' ss Score
8.68
3' ss Seq
AGTTATAATTATCTTGACAGTAT
3' ss Score
3.9
Exon sequences
Seq C1 exon
TATCTCCAATGTTCGTTGTTCGAGTCCTTGCTATAGCCTTGGCAATTCGATTCACCCTTAACACATTGATGTGGCTTGCCATTTTCAAAGAGACGTTTCAGCCAG
Seq A exon
GTACAGATATTTGCTGCATAAACCTACAATCTGAATTCCATTCCCAAAAACCAAAGAAATGTGGAAGGAAGAACTGACTCCACAAAATGGTTCCCTGGCCTCCATGTTCACTCCCTGGTACATGGGTACCCTCATATGCATGCCTACATGCAACATGTATGTGGGCACACACACACATAGAGTTTAAAAAGTGAAAAAATATATAAAAGCAAAGAAACATTCAGTAGTGAGAGTGAAAATGTTTTAAACCATAGCTTGGCTGTTCTACAAACATCCAAGTCACATTTGTTTACAGTAGAAGTTACTAAAGTTTAACAGTTATAATTATCTTGACAG
Seq C2 exon
TATTGTGCAACAAGGAAGTCCCAGTTTCCTCAAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000030149-Klrk1:NM_001083322:4
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
No protein impact description available
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Conservation
Rat
(rn6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 25092887
NKG2D-FL overexpression increases T cell cytotoxicity while NKG2D-TR overexpression decreases surface expression of NKG2D-FL and reduces cytotoxicity. NKG2D-TR knockdown increases T cell cytotoxic activity. Isoforms differ in their subcellular localization.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
Other AS DBs: