HsaINT0088997 @ hg19
Intron Retention
Gene
ENSG00000213809 | KLRK1
Description
killer cell lectin-like receptor subfamily K, member 1 [Source:HGNC Symbol;Acc:18788]
Coordinates
chr12:10532046-10532391:-
Coord C1 exon
chr12:10532299-10532391
Coord A exon
chr12:10532082-10532298
Coord C2 exon
chr12:10532046-10532081
Length
217 bp
Sequences
Splice sites
5' ss Seq
ACTGTAAGT
5' ss Score
8.59
3' ss Seq
ACTTATGGTTATTTTAATAGCAT
3' ss Score
5.15
Exon sequences
Seq C1 exon
CATCTCCATTTTTTTTCTGCTGCTTCATCGCTGTAGCCATGGGAATCCGTTTCATTATTATGGTAACAATATGGAGTGCTGTATTCCTAAACT
Seq A exon
GTAAGTGACAACAGAGAAGTAGATTGCAACATTGTCAATTTAACAATGCTAATGTATTATTTTTGTTAGTATTCATAAACACAGACACATAAACTAGAAATATTAAATGTATCTTTGTCACATTTTTGCTATTAGTCCAGAAATTTGTAAACTATATTTGCTTATACTATAAGTTACTAACAATACAAACTTTTAATACTTATGGTTATTTTAATAG
Seq C2 exon
CATTATTCAACCAAGAAGTTCAAATTCCCTTGACCG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000213809-KLRK1:NM_007360:4
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 25092887
This event
NKG2D-FL overexpression increases T cell cytotoxicity while NKG2D-TR overexpression decreases surface expression of NKG2D-FL and reduces cytotoxicity. NKG2D-TR knockdown increases T cell cytotoxic activity. Isoforms differ in their subcellular localization.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)