RnoINT0080312 @ rn6
Intron Retention
Gene
ENSRNOG00000061739 | Klrk1
Description
killer cell lectin like receptor K1 [Source:RGD Symbol;Acc:3180]
Coordinates
chr4:163396950-163397523:-
Coord C1 exon
chr4:163397431-163397523
Coord A exon
chr4:163396986-163397430
Coord C2 exon
chr4:163396950-163396985
Length
445 bp
Sequences
Splice sites
5' ss Seq
CTTGTAAGT
5' ss Score
8
3' ss Seq
AATTATAATTATTTTGATAGTGT
3' ss Score
3.11
Exon sequences
Seq C1 exon
TATCTCCACTGTTCGTTGTTCGAGTCCTTGTTGCAGCCATGACCATTCGCTTCACCGTTATCACATTGACATGGCTTGCTGTTTTCATAACTT
Seq A exon
GTAAGTGATGAGGCAGATAGTTAATCAATTGGGTGTAATGTGTTACCTTAATTAGCCTTCAGAAGCATGTGGGCAATCAGAGCAATGGTTCAGCCAGGTTCAGATACTTACTACATAAAGCCCACAACCTGAATTCCATCCCCCAAAACCACAGGAAAGTGGAAGGAAGAACTGACTCCACAAAATTGTTCTCTGACCTCCATATTCATTCACTGGCACATGGGTATCCTCACCCTCATGCCTGCATACACATGCATGTGGGCACACACACACTCATGCACTCATACACACATGCACTCATGCACTCATGCACGCATGCACGCATGCACAGAGTAGTAAGAGTGAAAGTATTTTAAACCGTAGCTTTGCTGTTTGACAAACATGCAAGTCACATTTGTTTATAGTAGAAGTTACTAACTCTTACCAATTATAATTATTTTGATAG
Seq C2 exon
TGTTATGCAACAAGGAAGTTTCAGTTTCCTCAAGAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSRNOG00000061739:ENSRNOT00000088151:4
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 1 annotated functions for this event
PMID: 25092887
NKG2D-FL overexpression increases T cell cytotoxicity while NKG2D-TR overexpression decreases surface expression of NKG2D-FL and reduces cytotoxicity. NKG2D-TR knockdown increases T cell cytotoxic activity. Isoforms differ in their subcellular localization.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]