RnoEX6030723 @ rn6
Exon Skipping
Gene
ENSRNOG00000004346 | Notch3
Description
notch 3 [Source:RGD Symbol;Acc:620761]
Coordinates
chr7:14170559-14173685:-
Coord C1 exon
chr7:14173572-14173685
Coord A exon
chr7:14172736-14172891
Coord C2 exon
chr7:14170559-14170784
Length
156 bp
Sequences
Splice sites
3' ss Seq
GCTTCCCCTCTCGCCTCCAGGCC
3' ss Score
10.14
5' ss Seq
CCAGTAAGT
5' ss Score
9.09
Exon sequences
Seq C1 exon
GTCATCAATGTGAGGTGCTGTCCCCCTGCACTCCAAGTCTCTGTGAGCACGGAGGCCACTGTGAGTCTGACCCTGACCAGCTGACTGTCTGTTCCTGTCCTCCAGGCTGGCAAG
Seq A exon
GCCCTCGATGCCAGCAGGATGTGGATGAATGTGCTGGTGCCTCACCTTGTGGCCCCCATGGTACCTGCACCAACCTGCCAGGGAGCTTCAGGTGCATCTGCCATGGAGGATACACTGGCCCTTTCTGTGATCAGGACATTGACGACTGTGACCCCA
Seq C2 exon
ACCCGTGCCTCAATGGTGGCTCCTGCCAGGATGGTGTGGGCTCCTTTTCCTGTTCTTGCCTCAGTGGCTTTGCTGGTCCTCGCTGTGCTCGGGATGTGGATGAATGTCTGAGCAGTCCCTGTGGCCCTGGCACCTGCACTGATCATGTAGCCTCTTTCACCTGTACCTGTCCACCTGGCTATGGAGGCTTCCACTGTGAGACTGACTTGCTGGACTGCAGCCCCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSRNOG00000004346-'17-18,'17-17,18-18=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0000822=EGF=PD(6.5=5.1),PF0000822=EGF=PU(90.6=74.4)
A:
PF0000822=EGF=PD(6.2=3.8),PF0764510=EGF_CA=WD(100=73.6),PF0000822=EGF=PU(9.7=5.7)
C2:
PF0000822=EGF=PD(87.1=35.5),PF0764510=EGF_CA=WD(100=59.2),PF0000822=EGF=PU(9.7=3.9)
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACCAGCTGACTGTCTGTTCCT
R:
GCAGTCCAGCAAGTCAGTCTC
Band lengths:
257-413
Functional annotations
There are 1 annotated functions for this event
PMID: 30674940
This study does not directly assess the function of the events. It reports that NOTCH3 has differential exon 16 depletion (-exon 16) between differentiation associated BAGS subtypes. Predicted vincristine resistant patients of the GCB subclass had significantly downregulated NOTCH3 -exon 16 transcript expression and tended to display adverse overall survival for R-CHOP treated patients. Thus, this exon display prognostic and predictive biomarker potential in GCB DLBCL.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]