Special

FBgn0033783 @ dm6

Biotype
protein_coding
Gene Symbol
CG17019
Description
This gene is referred to in FlyBase by the symbol DmelCG17019 (FBgn0033783). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is 2R:12930912..12934045. Its molecular function is described by: ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: protein K48-linked ubiquitination; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. 6 alleles are reported. The phenotypes of these alleles manifest in: indirect flight muscle; mitochondrion. The phenotypic classes of alleles include: stress response defective; locomotor behavior defective; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during late pupal stages, in adult female stages.
Coordinates
chr2R:12930912-12934045:-
Assembly

GENOMIC BROWSER[edit]


EXPRESSION VALUES[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Intron Retention
59
chr2R:12931543-12931601
-
4.36
67.7
0



Orthologous genes[edit]

Organism Assembly Gene ID Gene Name Orthology Type

Human hg38 ENSG00000092871 RFFL 1-to-3
Human hg38 ENSG00000170633 RNF34 1-to-3
Human hg19 ENSG00000092871 RFFL 1-to-3
Human hg19 ENSG00000170633 RNF34 1-to-3
Mouse mm10 ENSMUSG00000020696 Rffl 1-to-2
Mouse mm10 ENSMUSG00000029474 Rnf34 1-to-2
Mouse mm9 ENSMUSG00000020696 Rffl 1-to-2
Mouse mm9 ENSMUSG00000029474 Rnf34 1-to-2
Rat rn6 ENSRNOG00000001331 Rnf34 1-to-2
Rat rn6 ENSRNOG00000007596 Rffl 1-to-2
Cow bosTau6 ENSBTAG00000002315 RNF34 1-to-2
Cow bosTau6 ENSBTAG00000013645 RFFL 1-to-2
Chicken galGal4 ENSGALG00000002225 RFFL 1-to-2
Chicken galGal4 ENSGALG00000004190 RNF34 1-to-2
Chicken galGal3 ENSGALG00000002225 Q5ZI26_CHICK 1-to-2
Chicken galGal3 ENSGALG00000004190 RNF34 1-to-2
Zebrafish danRer10 ENSDARG00000038300 rnf34a 1-to-4
Zebrafish danRer10 ENSDARG00000042833 rffl 1-to-4
Zebrafish danRer10 ENSDARG00000054036 rnf34b 1-to-4
Zebrafish danRer10 ENSDARG00000056244 RFFL (2 of 2) 1-to-4