Special

FBgn0037659 @ dm6

Biotype
protein_coding
Gene Symbol
Kdm2
Description
The gene Lysine (K)-specific demethylase 2 is referred to in FlyBase by the symbol DmelKdm2 (CG11033, FBgn0037659). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (1 unique). Gene sequence location is 3R:9052495..9063245. Its molecular function is described by: zinc ion binding; histone demethylase activity (H3-trimethyl-K4 specific); DNA binding; histone demethylase activity (H3-K36 specific). It is involved in the biological process described with 8 unique terms, many of which group under: anatomical structure development; regulation of protein metabolic process; negative regulation of nitrogen compound metabolic process; muscle structure development; multicellular organismal process. 51 alleles are reported. The phenotypes of these alleles manifest in: embryonic/larval somatic muscle; nucleolus. The phenotypic classes of alleles include: lethal; phenotype; lethal - all die before end of P-stage; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.
Coordinates
chr3R:9052495-9063245:+
Assembly

GENOMIC BROWSER[edit]


EXPRESSION VALUES[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Alternative 5'ss
0
NA
+
17.07
63.64
0
Alternative 5'ss
52
chr3R:9052576-9052627
+
82.21
63.64
0
Intron Retention
908
chr3R:9052628-9053535
+
18.25
44.68
0



Orthologous genes[edit]

Organism Assembly Gene ID Gene Name Orthology Type

Human hg38 ENSG00000089094 KDM2B 1-to-3
Human hg38 ENSG00000099364 FBXL19 1-to-3
Human hg38 ENSG00000173120 KDM2A 1-to-3
Human hg19 ENSG00000089094 KDM2B 1-to-3
Human hg19 ENSG00000099364 FBXL19 1-to-3
Human hg19 ENSG00000173120 KDM2A 1-to-3
Mouse mm10 ENSMUSG00000029475 Kdm2b 1-to-3
Mouse mm10 ENSMUSG00000030811 Fbxl19 1-to-3
Mouse mm10 ENSMUSG00000054611 Kdm2a 1-to-3
Mouse mm9 ENSMUSG00000029475 Kdm2b 1-to-3
Mouse mm9 ENSMUSG00000030811 Fbxl19 1-to-3
Mouse mm9 ENSMUSG00000054611 Kdm2a 1-to-3
Rat rn6 ENSRNOG00000018986 Fbxl19 1-to-3
Rat rn6 ENSRNOG00000019145 Kdm2a 1-to-3
Rat rn6 ENSRNOG00000025702 Kdm2b 1-to-3
Cow bosTau6 ENSBTAG00000002328 KDM2B 1-to-3
Cow bosTau6 ENSBTAG00000040555 FBXL19 1-to-3
Cow bosTau6 ENSBTAG00000044032 KDM2A 1-to-3
Chicken galGal4 ENSGALG00000004225 KDM2B 1-to-2
Chicken galGal3 ENSGALG00000004225 KDM2B 1-to-2
Zebrafish danRer10 ENSDARG00000036593 kdm2ba 1-to-6
Zebrafish danRer10 ENSDARG00000046010 kdm2bb 1-to-6
Zebrafish danRer10 ENSDARG00000059653 kdm2aa 1-to-6
Zebrafish danRer10 ENSDARG00000100575 KDM2B (2 of 2) 1-to-6
Zebrafish danRer10 ENSDARG00000103362 FBXL19 1-to-6