DmeALTA0007767-2/4 @ dm6
Alternative 3'ss
Gene
FBgn0000289 | cg
Description
The gene combgap is referred to in FlyBase by the symbol Dmelcg (CG8367, FBgn0000289). It is a protein_coding_gene from Dmel. It has 12 annotated transcripts and 12 polypeptides (10 unique). Gene sequence location is 2R:14173693..14182838. Its molecular function is described by: DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated; imaginal disc-derived wing morphogenesis. 41 alleles are reported. The phenotypes of these alleles manifest in: adult antennal segment; adult central brain; embryonic/larval digestive system; alimentary canal; imaginal tissue. The phenotypic classes of alleles include: partially lethal; increased mortality; phenotype; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages.
Coordinates
chr2R:14177175-14178021:+
Coord C1 exon
chr2R:14177175-14177477
Coord A exon
chr2R:14177861-14177884
Coord C2 exon
chr2R:14177885-14178021
Length
24 bp
Sequences
Splice sites
5' ss Seq
CAAGTAAGC
5' ss Score
7.47
3' ss Seq
CGGTGCAACAACACTCTTAGGTG
3' ss Score
1.77
Exon sequences
Seq C1 exon
ATCTGCTAGTGGATCCGGCCACGGCCGCAGCAGCTGCAGCCGCCGCTGGTGGGGATTCGGGTCTCGCCCACCACCATACGTTGACCAATGGCAGCATTGTTGATGCGAAGACCGGACAGACGGTGCTAACCGCCGGATCTGCGGCGGCCAAGTCGCACTTCAGCTCGATCGGAGCACTGCATCTTACGCAAGAGGAGTGCAACGAGATCCTGATCAAGCGCGCCATCGCTGCCGGCCACCATCAGACGCACACGATCACCGCTGCCGACGGATCCCATCACCATGCGTCCGGCGGGACACCAA
Seq A exon
GTGACATACTTCCTGGTATTTCAG
Seq C2 exon
TTCAAGTGCAGAAAGTCATACAAGGACTGGAGGATAACGAGGACTCGCAAGGCGAAGCACCCAACCTAAAGTTGGAGCCAGGCACATTAGAGTTGTCCCCGAAGACCGAACTACAGGAATCAATGCATTTCAGCGAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000289-8-9,8-8,8-7,8-6-2/4
Average complexity
Alt3
Mappability confidence:
NA
Protein Impact
Protein isoform when splice site is used (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.340 A=NA C2=0.761
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
FBpp0288474
Main Skipping Isoform:
FBpp0308983
Other Inclusion Isoforms:
FBpp0086655, FBpp0086656, FBpp0086657, FBpp0086658, FBpp0288473
Other Skipping Isoforms:
FBpp0111707, FBpp0308982, FBpp0308984, FBpp0312412
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GATCCCATCACCATGCGTCC
R:
ACTTTAGGTTGGGTGCTTCGC
Band lengths:
105-129
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)