DmeEX0007441 @ dm6
Exon Skipping
Gene
FBgn0000289 | cg
Description
The gene combgap is referred to in FlyBase by the symbol Dmelcg (CG8367, FBgn0000289). It is a protein_coding_gene from Dmel. It has 12 annotated transcripts and 12 polypeptides (10 unique). Gene sequence location is 2R:14173693..14182838. Its molecular function is described by: DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated; imaginal disc-derived wing morphogenesis. 41 alleles are reported. The phenotypes of these alleles manifest in: adult antennal segment; adult central brain; embryonic/larval digestive system; alimentary canal; imaginal tissue. The phenotypic classes of alleles include: partially lethal; increased mortality; phenotype; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages.
Coordinates
chr2R:14176612-14178021:+
Coord C1 exon
chr2R:14176612-14176691
Coord A exon
chr2R:14177175-14177477
Coord C2 exon
chr2R:14177885-14178021
Length
303 bp
Sequences
Splice sites
3' ss Seq
CCATCGAATTGAAAAAACAGATC
3' ss Score
0.61
5' ss Seq
CAAGTAAGC
5' ss Score
7.47
Exon sequences
Seq C1 exon
AGTTATCACTGCCGGCGGAGCATCGACGGTGGTCAAGAAGCAGGACAACAATCAGCAGGTCCTGAGCCTCGACAAGAACT
Seq A exon
ATCTGCTAGTGGATCCGGCCACGGCCGCAGCAGCTGCAGCCGCCGCTGGTGGGGATTCGGGTCTCGCCCACCACCATACGTTGACCAATGGCAGCATTGTTGATGCGAAGACCGGACAGACGGTGCTAACCGCCGGATCTGCGGCGGCCAAGTCGCACTTCAGCTCGATCGGAGCACTGCATCTTACGCAAGAGGAGTGCAACGAGATCCTGATCAAGCGCGCCATCGCTGCCGGCCACCATCAGACGCACACGATCACCGCTGCCGACGGATCCCATCACCATGCGTCCGGCGGGACACCAA
Seq C2 exon
TTCAAGTGCAGAAAGTCATACAAGGACTGGAGGATAACGAGGACTCGCAAGGCGAAGCACCCAACCTAAAGTTGGAGCCAGGCACATTAGAGTTGTCCCCGAAGACCGAACTACAGGAATCAATGCATTTCAGCGAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000289_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.369 A=0.340 C2=0.797
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0111707
Main Skipping Isoform:
FBpp0308982
Other Inclusion Isoforms:
FBpp0086656, FBpp0288473, FBpp0288474, FBpp0308983, FBpp0308984
Other Skipping Isoforms:
FBpp0086655, FBpp0086657, FBpp0086658, FBpp0312412
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GTTATCACTGCCGGCGGAG
R:
CGCTGAAATGCATTGATTCCTGT
Band lengths:
214-517
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)