DmeALTA0008600-2/2 @ dm6
Alternative 3'ss
Gene
FBgn0261260 | mgl
Description
The gene Megalin is referred to in FlyBase by the symbol Dmelmgl (CG42611, FBgn0261260). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (1 unique). Gene sequence location is X:9358496..9500129. Its molecular function is described by: calcium ion binding. It is involved in the biological process described with: chitin-based cuticle development; regulation of adult chitin-containing cuticle pigmentation; regulation of endocytosis. 39 alleles are reported. The phenotypes of these alleles manifest in: wing blade posterior compartment; trichogen cell; adult cuticle; wing blade; procuticle. The phenotypic classes of alleles include: viable; lethal; visible; body color defective; lethal - all die before end of pupal stage; some die during pupal stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late pupal stages.
Coordinates
chrX:9471999-9500129:-
Coord C1 exon
chrX:9499886-9500129
Coord A exon
chrX:9472658-9472660
Coord C2 exon
chrX:9471999-9472657
Length
3 bp
Sequences
Splice sites
5' ss Seq
CGAGTGAGT
5' ss Score
8.49
3' ss Seq
TTCCGCTTATTTCATTAAAGCAG
3' ss Score
4.13
Exon sequences
Seq C1 exon
CGTCGTCGTGAACGGTCAGCCAGCGCGGCTAATAAGTAACCAACTGTAGTGACAGTGCGATAGTGACTCTGATCCGAACCCGAATCCCAGGCCCACAACAGATACGTCCAGCGTGTGGGCAGCCAGAACAGAGTGACAAGAATATCGGAGCCGACAACAACAGTAAACTGAAAGATAGAAAGAAAGAAAGAAAGGCCAACCTGCCGATTAAATTCCAATTGAGTGTTACGAGTTTTTTTTTCGA
Seq A exon
CAG
Seq C2 exon
CCCACCAAAAGAAAAAAATAAATATTCCAAAAAGTAAAACGCAACAAAGCCAGAGGAGCGGGCAACCCTAAAAAAGACAGAAGTGCGGTGGGCAGAGAAGAGGTCACCAGAGGGTCACCAAAAAAAACAAAAAAAAACCGAAACGAACAAGACCCAAATCCGAATCGAGGATTCCCACAGAAACCAAACAGGAAAAGGAGAAAGGAGCGGAGCAGCAAGCGAAGCGCCCGACGAACCAAAAATGAATCCGACGCCCGTGGGCATTGGATTCGGATTTGGTCGCAAGCCGCCCAGCAAGGCCAGAATGCGTTCTCGCTGGCGACCACCATCAGCGACAACCCTGCTGACCCATGACCCCGCCAACGGCGACAGCCATACGGCCGCCGATCCGCTGCAGGTCACTGATGCCGCCCCATCGGGCCCACCATCATCTTCATCATCCTCGCCCATCGGCGACCGCCATTCACAGCATCACAGCAGCAGCGCCATCGATCGGAGGC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261260-0-5,0-4-2/2
Average complexity
Alt3
Mappability confidence:
NA
Protein Impact
5' UTR
No structure available
Features
Disorder rate (Iupred):
C1=NA A=NA C2=0.864
Domain overlap (PFAM):
C1:
NA
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0291363
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0310026, FBpp0310027, FBpp0310028
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGCCAACCTGCCGATTAAATT
R:
TCCTCTGGCTTTGTTGCGTTT
Band lengths:
108-111
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)