FBgn0261260 @ dm6
Biotype
protein_coding
Gene Symbol
mgl
Description
The gene Megalin is referred to in FlyBase by the symbol Dmelmgl (CG42611, FBgn0261260). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (1 unique). Gene sequence location is X:9358496..9500129. Its molecular function is described by: calcium ion binding. It is involved in the biological process described with: chitin-based cuticle development; regulation of adult chitin-containing cuticle pigmentation; regulation of endocytosis. 39 alleles are reported. The phenotypes of these alleles manifest in: wing blade posterior compartment; trichogen cell; adult cuticle; wing blade; procuticle. The phenotypic classes of alleles include: viable; lethal; visible; body color defective; lethal - all die before end of pupal stage; some die during pupal stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late pupal stages.
Coordinates
chrX:9358496-9500129:-
Assembly
GENOMIC BROWSER[edit]
EXPRESSION VALUES[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)
EVENTS AND AS PROFILES[edit]
Associated events[edit]
Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Orthologous genes[edit]
| Organism | Assembly | Gene ID | Gene Name | Orthology Type
|
|---|---|---|---|---|
| Human | hg38 | ENSG00000081479 | LRP2 | 1-to-1 |
| Human | hg19 | ENSG00000081479 | LRP2 | 1-to-1 |
| Mouse | mm10 | ENSMUSG00000027070 | Lrp2 | 1-to-1 |
| Mouse | mm9 | ENSMUSG00000027070 | Lrp2 | 1-to-1 |
| Rat | rn6 | ENSRNOG00000056184 | Lrp2 | 1-to-1 |
| Cow | bosTau6 | ENSBTAG00000004555 | LRP2 | 1-to-1 |
| Chicken | galGal4 | ENSGALG00000010858 | LRP2 | 1-to-1 |
| Chicken | galGal3 | ENSGALG00000010858 | LRP2 | 1-to-1 |
| Zebrafish | danRer10 | ENSDARG00000007906 | lrp2b | 1-to-2 |
| Zebrafish | danRer10 | ENSDARG00000102506 | lrp2a | 1-to-2 |